研究领域
生物医学工程、影像医学与核医学。具体开展的研究内容：
① 开展多种纳米药物载体的设计、不同修饰对其体内外性能的影响、以及载药后对肿瘤的治疗研究。
② 瘤多模态纳米分子探针的设计、合成及应用，通过对纳米材料进行靶向及多种成像探针（放射性核素/MR/荧光等）的联合修饰，实现肿瘤的早期准确诊断。
③ 药物的放射性核素标记及临床前药代动力学研究。
近期论文
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1. Jinjian Liu, Hongzhang Deng, Qiang Liu, Liping Chu, Yumin Zhang, Cuihong Yang, Xuefei Zhao, Pingsheng Huang, Liandong Deng, Anjie Dong*, Jianfeng Liu*. Integrin-targeted pH-responsive micelles for enhanced anticancer efficiency in vitro and in vivo. Nanoscale. 2015 Feb 13; 7(10): 4451-60. IF：7.394
2. Cuihong Yang, Liping Chu, Yumin Zhang, Yang Shi, Jinjian Liu, Qiang Liu, Saijun Fan, Zhimou Yang, Dan Ding*, Deling Kong*, Jianfeng Liu*. Dynamic biostability, biodistribution, and toxicity of L/D-peptide-based supramolecular nanofibers. ACS Applied Materials & Interfaces. 2015 Feb 4; 7(4):2735-44. IF:6.723
3. Pingsheng Huang, Yumin Zhang, Weiwei Wang, Junhui Zhou, Yu Sun, Jinjian Liu, Deling Kong, Jianfeng Liu*, Anjie Dong*. Co-delivery of doxorubicin and 131I by thermosensitive micellar-hydrogel for enhanced in situ synergetic chemoradiotherapy. Journal of Controlled Release. 2015 Nov 10;220(Pt A): 456-464. IF:7.705
4. Hongzhang Deng, Xuefei Zhao, Jinjian Liu, Jianhua Zhang, Liandong Deng, Jianfeng Liu*, Anjie Dong*. Synergistic Dual-pH Responsive Copolymer Micelles for Impediment of the Blood Drug Release and Motivation of the Intracellular. Nanoscale. 2016 Jan 7;8(3):1437-50 IF：7.394
5. Pingsheng Huang, Jinjian Liu, Weiwei Wang, Yumin Zhang, Fuli Zhao, Deling Kong, Jianfeng Liu*, Anjie Dong*. Zwitterionic Nanoparticles Constructed from Bioreducible RAFT-ROP Double Head Agent for Shell Shedding Triggered Intracellular Drug Delivery. Acta Biomaterialia. 2015 Nov 19. pii: S1742-7061 (15)30214-2. IF:6.025
6. Hongzhang Deng, Yumin Zhang, Xue Wang, Jianhua Zhang, Yan Cao, Jinjian Liu, Jianfeng Liu*, Liandong Deng*, Anjie Dong. Balancing the stability and drug release of polymer micelles by the coordination of dual-sensitive cleavable bonds in cross-linked core. Acta Biomaterialia. 2015 Jan;11:126-36. IF:6.025
7. Jianfeng Liu, Jinjian Liu, Liping Chu, Yumin Zhang, Hongyan Xu, Deling Kong, Zhimou Yang, Cuihong Yang, Dan Ding. Self-assembling peptide of D-amino acids boosts selectivity and antitumor efficacy of 10-Hydroxycamptothecin. ACS Applied Materials & Interfaces. 2014 Mar 23; 6(8):5558-65. IF:6.723
8. Pingsheng Huang, Jinjian Liu, Weiwei Wang, Chen Li, Junhui ZHou, Xue Wang, Liandong Deng, Deling Kong, Jianfeng Liu*, Anjie Dong*. Zwitterionic nanoparticles constructed with well-defined reduction-responsive shell and pH-sensitive core for "spatiotemporally pinpointed" drug delivery. ACS Applied Materials & Interfaces. 2014 Aug 27; 6(16):14631-43. IF:6.723
9. Pingsheng Huang, Cuihong Yang, Jinjian Liu, Weiwei Wang, Shutao Guo, Jiao Li, Yu Sun, Hongxu Dong, Liandong Deng, Jianhua Zhang, Jianfeng Liu*, Anjie Dong*. Improving oral delivery efficiency of anticancer drugs by chitosan coated polycaprolactone-grafted hyaluronic acid nanoparticles. Journal of Materials Chemistry B. 2014;2:4021-4033. IF:4.726
10. Jianfeng Liu, Jinjian Liu, Hongyan Xu, Yumin Zhang, Liping Chu, Qingfen Liu, Naling Song, Cuihong Yang*. Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery. International Journal of Nanomedicine. 2014; 9:197-207. IF：4.383
11. Jianfeng Liu*, Jinjian Liu, Liping Chu, Lingling Tong, Hongjun Gao, Cuihong Yang, Dezhi Wang, Linqi Shi, Deling Kong, Zongjin Li*. Synthesis, biodistribution, and imaging of PEGylated-acetylated polyamidoamine dendrimers. Journal of Nanoscience and Nanotechnology. 2014 May; 14(5): 3305-3312. IF:1.556
12. Hongjun Gao, Jinjian Liu, Cuihong Yang, Tangjian Cheng, Liping Chu, Hongyan Xu, Aimin Meng, Saijun Fan, Linqi Shi*, Jianfeng Liu*. The impact of PEGylation patterns on the in vivo biodistribution of mixed shell micelles. International Journal of Nanomedicine. 2013;8: 4229-4246. IF：3.463
13. Hongjun Gao, Jie Xiong, Tangjian Cheng, Jinjian Liu, Liping Chu, Jianfeng Liu *, Rujiang Ma, Linqi Shi*. In vivo biodistribution of mixed shell micelles with tunable hydrophilic/hydrophobic surface. Biomacromolecules. 2013 Feb 11;14(2):460-7. IF:5.371
14. Dongxia Li, Jinjian Liu, Liping Chu, Jianfeng Liu*, Zhimou Yang*. A novel mixed-component molecular hydrogel system with excellent stabilities. Chemical Communications (Camb). 2012 Jun 21;48(49): 6175-7. IF:6.378
15. Jianfeng Liu, Jinjian Liu, Liping Chu, Yanming Wang, Yajun Duan, Lina Feng, Cuihong Yang, Ling Wang, Deling Kong. Novel peptide-dendrimer conjugates as drug carrier for targeting nonsmall cell lung cancer. International Journal of Nanomedicine. 2011;6:59-69. IF：3.463
16. Zhenfang Zhang, Cuihong Yang, Yajun Duan, Yanming Wang, Jianfeng Liu*, Lianyong Wang, Kong D*. Poly(ethylene glycol) analogs grafted with low molecular weight poly(ethylene imine) as non-viral gene vectors. Acta Biomaterialia. 2010 Jul;6(7):2650-7. IF:5.093
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