个人简介

学习经历 1993.9-1997.6，中国科大数学系计算数学及其应用软件专业，获理学学士学位。 1997.9-2000.6，中国科大数学系应用数学专业攻读硕士学位（导师：赵林城教授），获理学硕士学位。 2001.2-2003.12，中国科大统计与金融系概率论与数理统计专业（导师：应志良教授、赵林城教授），获理学博士学位。 工作经历 2000.7-2011，中国科大统计与金融系，助教/讲师。 2011.2-2018.5，复旦大学生物统计学研究所，研究员、博导。 2018.6至今，中国科大统计与金融系，教授、博导。 博士后研究 2004.3-2005.4，乔治华盛顿大学统计系（postdoctoral scientist） 2006.8-2007.11，耶鲁大学医学院（postdoctoral associate） 2009.1-2010.12，美国NIH国立癌症研究所（postdoctoral visiting fellow） 在Biometrika、Biometrics、Bioinformatics、Biostatistics、Annals of Applied Statistics、Statistics in Medicine、Statistica Sinica等国内外统计学期刊上发表论文50多篇，获得近600次引用（google scholar检索，其中大部分为他引），单篇引用次数超过50的论文有5篇；参与撰写的教材《遗传学中的统计方法》（科学出版社，2006年）被多所高校采用。

研究领域

健康大数据分析和统计计算。目前研究兴趣为医学领域内大数据（电子病历档案、高通量测序数据）的统计方法学研究及其应用，并开发相应R软件包。

部分研究项目 高通量生物医学数据的统计方法学研究，引进人才启动基金，100万，2018.6.1-2020.5.31，主持。 基于新一代高通量测序数据的若干统计方法学研究，国家自然科学基金委（面上项目），48万，2018.1.1-2021.12.31，主持。 基于新一代测序数据的统计遗传学新理论、方法与应用，973计划，900万， 2012.1.1-2016.8.31，主持。 全基因组DNA甲基化研究中的统计学方法，国家自然科学基金面上项目， 50万，2014.1.1-2017.12.31，课题骨干。 人类基因关联分析的若干问题，国家自然科学基金青年项目，15万，2008.1.1-2010.12.31，主持。

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[01] Zhang H, Chatterjee N, Rader D, Chen J (2018). Adjustment of non-confounding covariates in case-control genetic associaiton studies. Annals of Applied Statistics 12(1):200-221. [02] Zhou B, Wen S, Wang L, Jin L, Li H, Zhang H# (2017). AntCaller: An accurate variant caller incorporating ancient DNA damage. Molecular Genetics and Genomics 292(6):1419-1430. [03] Wang C, Shen Q, Du L, Xu J, Zhang H# (2016). armDNA: A functional beta model for detecting age-related genomewide DNA methylation marks. Statistical Methods in Medical Research DOI: 10.1177/0962280216683571. [04] Kang G, Du L, Zhang H# (2016). multiDE: a dimension reduced model based statistical method for di erential expression analysis using RNA-sequencing data with multiple treatment conditions. BMC Bioinformatics 17: 248. [05] Shen Q, Hu J, Jiang N, Hu X, Luo Z, Zhang H# (2016). contamDE: Difierential expression analysis of RNA-seq data for contaminated tumor samples. Bioinformatics 32(5): 705-712. [06] Hu J, Li T, Xiu Z, Zhang H# (2015). MAFsnp: A Multi-sample Accurate and Flexible SNP Caller Using Next-generation Sequencing Data. PLoS ONE 10(8): e0135332. doi:10.1371/journal.pone.0135332. [07] Zhang H#, Xu J, Jiang N, Hu X, Luo Z (2015). PLNseq: a multivariate Poisson lognormal distribution for high-throughput matched RNA-sequencing read count data. Statistics in Medicine 34: 1577-1589. [08] Zhang H, Qin J, Landi M, Caporaso N, Yu K (2013). A copula-model based semiparametric interaction test under the case-control design. Statistica Sinica. 23: 1505-1521. [09] Zhang H, Zeng D, Olschwang S, Yu K (2013). Semiparametric inference on the penetrances of rare genetic mutations based on a case-family design. Journal of Statistical Planning and Inference. 143: 368-377. [10] Zhang H, Wacholder S, Qin J, Hildesheim A, Yu K (2011). Improved genetic association tests for an ordinal outcome representing the disease progression process. Genetic Epidemiology. 35:499-505. [11] Zhang H, Ahn J, Yu K (2011). Comparing statistical methods for removing seasonal variation from vitamin D measurements in case-control studies. Statistics and Its Interface. 4:85-93. [12] Li T, Li Z, Ying Z, Zhang H#. (2010). Influence of population stratification on population based marker-disease association analysis. Annals of Human Genetics. 74:351-360. [13] Zhang H, Olschwang S, Yu K. (2010). Statistical inference on the penetrances of rare genetic mutations based on a case-family design. Biostatistics. 11:519-532. [14] Wu C*, Zhang H*, Liu X, DeWan A, Dubrow R, Ying Z, Yang Y, Hoh J (2009). Detecting essential and removable interactions in genome-wide association studies. Statistics and Its Interface. 2:161-170. [15] Zhang H, Chen H, Li Z. (2009). Large sample interval mapping method for genetic trait loci infinite regression mixture models. Journal of Statistical Planning and Inference. 139:764-779. [16] Yan T, Yang Y, Cheng X, DeAngelis MM, Hoh J, Zhang H# (2009). Genotypic association analysis using discordant-relative-pairs. Annals of Human Genetics. 73:84-94. [17] Francis P*, Zhang H*, DeWan A, Hoh J, Klein M (2008). Joint e ects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population. Molecular Vision. 14:1395-1400. [18] Zhang H, Morrison MA, DeWan A, Adams S, Andreoli M, Huynh N, Regan M, Brown A, Miller JW, Kim IK, Hoh J, DeAngelis MM (2008). The NEI/NCBI dbGAP database: Genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. BMC Medical Genetics. 9:51. [19] Chen K*, Ying Z*, Zhang H*, Zhao L* (2008). Analysis of least absolute deviation. Biometrika. 95(1):107-122. [20] Zhang H, Chen H, Li Z. (2008). An explicit representation of the limit of the LRT for interval mapping of quantitative trait loci. Statistics and Probability Letters. 78:207-213. [21] Zhang Han, Zhang Hong#, Li Zhaohai, Zheng Gang (2007). Statistical methods for haplotype-based matched case-control association studies. Genetic Epidemiology. 31(4):316-326. [22] Zhang H, Zheng G, Li Z (2006). Statistical analysis for haplotype-based matched case-control studies. Biometrics, 62:1124-1131.