Fierz, Beat - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Beat Fierz was born in Basel, Switzerland, and studied Molecular Biology at the Biozentrum of the University of Basel from 1998 – 2001. He then became interested in quantitative aspects of biology and obtained a Diploma in Biophysical Chemistry under the supervision of Prof. Thomas Kiefhaber in 2002. Subsequently, he performed his PhD studies (2002-2006) in Prof. Kiefhaber’s lab at the Biozentrum, where he investigated the dynamics of synthetic polypeptides and protein secondary structure elements using ultrafast time-resolved spectroscopy. In 2007 he joined the laboratory of Prof. Tom W Muir at the Rockefeller University, New York, and later Princeton University, New Jersey. There, he studied the folding behavior of chromatin fibers as well as the stability of nucleosome particles, depending on histone post-translational modifications. In 2012, Beat Fierz was appointed Tenure Track Assistant Professor for the newly created Chaire Fondation Sandoz en chimie biophysique des macromolécules.

研究领域

The research of Prof. Beat Fierz focuses on the study of the structure, dynamics and function of chromatin and related multi-protein complexes in vitro and in cells. These investigations require an interdisciplinary approach at the interface of chemistry, biology and biophysics.

近期论文

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A. Dhall, S. Wei, B. Fierz, C. L. Woodcock and T.-H. Lee et al. Sumoylated Human Histone H4 Prevents Chromatin Compaction by Inhibiting Long-range Internucleosomal Interactions, in Journal of Biological Chemistry, vol. 289, num. 49, p. 33827-33837, 2014. B. Fierz. Chromatin as a Dynamic Platform for Protein-Protein Interactions. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 2014. U. T. T. Nguyen, L. Bittova, M. M. Müller, B. Fierz and Y. David et al. Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries, in Nature Methods, 2014. H. Pick, S. Kilic and B. Fierz. Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function, in Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2014. B. Fierz. Synthetic Chromatin Approaches To Probe the Writing and Erasing of Histone Modifications, in ChemMedChem, vol. 9, num. 3, p. 495-504, 2014. D.-H. Kim, Z. Tang, M. Shimada, B. Fierz and B. Houck-Loomis et al. Histone H3 K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes, in Molecular and Cellular Biology, 2013. S. Neumaier, A. Reiner, M. Büttner, B. Fierz and T. Kiefhaber. Testing the diffusing boundary model for the helix-coil transition in peptides, in Proceedings of the National Academy of Sciences, 2013. B. Fierz, S. Kilic, A. R. Hieb, K. Luger and T. W. Muir. Stability of Nucleosomes Containing Homogenously Ubiquitylated H2A and H2B Prepared Using Semisynthesis, in Journal of the American Chemical Society, vol. 134, num. 48, p. 19548-51, 2012. B. Fierz and T. W. Muir. Chromatin as an expansive canvas for chemical biology, in Nature chemical biology, vol. 8, num. 5, p. 417-27, 2012. S. J. Whitcomb, B. Fierz, R. K. McGinty, M. Holt and T. Ito et al. Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2, in The Journal of biological chemistry, vol. 287, num. 28, p. 23718-25, 2012. B. Fierz, C. Chatterjee, R. K. McGinty, M. Bar-Dagan and D. P. Raleigh et al. Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction, in Nature chemical biology, vol. 7, num. 2, p. 113-9, 2011. C. Chatterjee, R. K. McGinty, B. Fierz and T. W. Muir. Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation, in Nature chemical biology, vol. 6, num. 4, p. 267-9, 2010. B. Fierz, A. Reiner and T. Kiefhaber. Local conformational dynamics in alpha-helices measured by fast triplet transfer, in Proceedings of the National Academy of Sciences of the United States of America, vol. 106, num. 4, p. 1057-62, 2009. B. Heinz, B. Schmidt, C. Root, F. Milota and B. Fierz et al. Slow fluorescence and fast intersystem crossing - The xanthone anomaly, in Ultrafast Phenomena XV, p. 513-515, Springer Series in Chemical Physics 88, 2007. B. Fierz and T. Kiefhaber. End-to-end vs interior loop formation kinetics in unfolded polypeptide chains, in Journal of the American Chemical Society, vol. 129, num. 3, p. 672-679, 2007. B. Fierz, H. Satzger, C. Root, P. Gilch and W. Zinth et al. Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale, in Proceedings of the National Academy of Sciences of the United States of America, vol. 104, num. 7, p. 2163-8, 2007. B. Heinz, B. Schmidt, C. Root, H. Satzger and F. Milota et al. On the unusual fluorescence properties of xanthone in water, in Physical chemistry chemical physics : PCCP, vol. 8, num. 29, p. 3432-3439, 2006. B. Fierz, K. Joder, F. Krieger and T. Kiefhaber. Using triplet-triplet energy transfer to measure conformational dynamics in polypeptide chains, in Methods in molecular biology, vol. 350, p. 169-187, 2006. B. Fierz and T. Kiefhaber. Dynamics of Unfolded Polypeptide Chains, in Protein folding handbook, p. 809-855, 2005. F. Krieger, B. Fierz, F. Axthelm, K. Joder and D. Meyer et al. Intrachain diffusion in a protein loop fragment from carp parvalbumin, in Chemical Physics, vol. 307, num. 2-3 SPEC.ISS., p. 209-215, 2004. H. Satzger, B. Schmidt, C. Root, W. Zinth and B. Fierz et al. Ultrafast quenching of the xanthone triplet by energy transfer: New insight into the intersystem crossing kinetics, in Journal of Physical Chemistry A, vol. 108, num. 46, p. 10072-10079, 2004.