Chen Hao - New Jersey Institute of Technology - Department of Chemistry and Environmental Science

个人简介

Dr. Hao Chen joined the Department of Chemistry and Environmental Science at NJIT in the fall of 2018, after working at Ohio University for 11 years (2007-2018). Professional Preparation Wuhan University, B.S., Chemistry, 1996 Shanghai Institute of Organic Chemistry, M.S., Polymer Chemistry and Physics, 1999 (advisor: J. X. Wen) University of Massachusetts at Dartmouth,M.S., Analytical Chemistry, 2001 (advisor: Y. G. Zuo) Purdue University, Ph.D., Analytical Chemistry, 2005 (advisor: R. G. Cooks) Purdue University, Postdoctoral Research Associate, 2005-2007 (advisor: R. G. Cooks) Washington University, Visiting Scientist, 2006-2007 (advisor: M. L. Gross) Stanford University, Visiting Professor, 2014 (advisor: R. N. Zare) Awards Research Advisor of the Year, Albert Dorman Honors College of NJIT, 2020 Presidential Research Scholar, Ohio University, 2017 Merck Technology Collaboration Award, Merck & Co. 2016 NSF Early Career Award, 2012 Ron Hites Award for Outstanding Publication in JASMS, 2012 American Society for Mass Spectrometry (ASMS) Research Award, 2010

研究领域

Mass spectrometry is a fascinating analytical and biological technology. Our research interest is broad and we are working on organic, biological, environmental and forensic mass spectrometry. In Particular, our research focuses on electrochemical mass spectrometry.

近期论文

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Chengyuan Liu, Qi Wang, Brian E. Hivick, Yongling Ai, Pier Alexandre Champagne, Yang Pan*, and Hao Chen*, Capture of electrochemically-generated fleeting carbazolium radical ion and elucidation of carbazole dimerization mechanism by mass spectrometry, Anal. Chem., 2020, Accepted (a supplenmentary cover). Q. Wang, M. Bhattarai, P. Zhao, T. Alnsour, M. Held,* A. Faik,* H. Chen,* Fast and Sensitive Detection of Oligosaccharides Using Desalting Paper Spray Mass Spectrometry (DPS-MS), J. Am. Soc. Mass Spectrom. 2020, in press. Xiaowei Song, Hao Chen, Richard N. Zare*, Coulometry-Assisted Quantitation in Spray Ionization Mass Spectrometry, J. Mass Spectrom. 2020, in press. Pengyi Zhao, Qi Wang, Manpreet Kaur, Yong-Ick Kim, Howard D. Dewald, Olivier Mozziconacci, Yong Liu, and Hao Chen*, Absolute Quantitation of Proteins by Coulometric Mass Spectrometry, Analytical Chemistry, 2020, 92, 7877–7883. Xiaowei Song and Hao Chen*, Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) for Tissue Analysis, Encyclopedia of Analytical Chemistry, 2020, Accepted. Teng Yuan, Pengyi Zhao, Shun Teng, Yaping Yi, Jin Wang, Chuan Shan, Lukasz Wojtas, Jonathan Jean, Hao Chen*, Xiaodong Shi*, Regioselective Crossed Aldol Reactions under Ambient Conditions via Synergistic Gold/Iron Catalysis, Chem (Impact Factor 18.2, Cell Press), 2020, 6, 1420–1431. Jin Wang, Chiyu Wei, Xuming Li, Pengyi Zhao, Chuan Shan, Lukasz Wojtas, Hao Chen, Xiaodong Shi*, Gold Redox Catalysis with Selenium Cation as Mild Oxidant, Chem. Eur. J. 2020, 26, 5946-5950. Kai Luo, Jia Li, Yufei Cao, Chengyuan Liu, Jun Ge, Hao Chen, Richard N. Zare*, Reaction of chloroauric acid with histidine in microdroplets yields catalytic Au-(His)2 complex, Chemical Science, 2020, 11, 2558. Xiaoqin Zhong, Hao Chen, Richard N. Zare*, Ultrafast enzymatic digestion of proteins by microdroplet mass spectrometry, Nature Communications, 2020, 11:1049. Karthik Sambath, Zhaoxiong Wan, Qi Wang, Hao Chen, Yuewei Zhang*, BODIPY-Based Photoacid Generators (PAGs) for Light-Induced Cationic Polymerization, Organic Letters, 2020, 22, 1208–1212. Rahul Narayanan, Xiaowei Song, Hao Chen, Richard Zare,* Teflon Spray Ionization Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2020, 31, 234-239. Chengyuan Liu, Jia Li, Hao Chen, and Richard N. Zare*, Scale-Up of Microdroplet Reactions by Heated Ultrasonic Nebulization, Chemical Science, 2019, 10, 9367-9373. Xiaohan Ye,‡ Pengyi Zhao,‡ Shuyao Zhang, Yanbin Zhang, Qilin Wang, Chuan Shan, Lukasz Wojtas, Hao Guo*, Hao Chen*, and Xiaodong Shi,* Facilitating Gold Redox Catalysis with Electrochemistry: An Efficient “Chemical-Oxidant-Free” Approach (Hot paper, ‡ equal contribution), Angew. Chem. Int. Ed., 2019, 58, 17226 –17230. Pengyi Zhao, Richard N. Zare*, Hao Chen*, Absolute Quantitation of Oxidizable Peptides Using Coulometric Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2019, 30, 2398-2407. Pengyi Zhao, Yong Guo*, Howard D. Dewald*, and Hao Chen*, Improvements for Absolute Quantitation Using Electrochemical Mass Spectrometry, Int. J. Mass Spectrom. 2019, 443, 41-45. Chang Xu, Qiuling Zheng, Pengyi Zhao, Joseph Paterson, Hao Chen*, A New Quantification Method Using Electrochemical Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2019, 30, 685–693. X. Song, H. Chen, R. N. Zare*, Conductive Polymer Spray Ionization Mass Spectrometry for Biofluid Analysis, Anal. Chem., 2018, 90, 12878–12885. P. Zhao, T. White, R. Graham Cooks,* Q. Chen,* Yong Liu and H. Chen*, “Detection of Neutral Species CO Lost During Ionic Dissociation Using Atmospheric Pressure Thermal Dissociation Mass Spectrometry (APTD-MS)", J. Am. Soc. Mass Spectrom. 2018, 29, 2317-2326. Zhengzheng Chen, Zhongyao Jiang, Fanpeng Kong, Hao Chen, Bo Tang*, “Target Discovery of Ebselen with a Biotinylated Probe”, Chem. Commun., 2018, 54, 9506-9509. Qiuling Zheng, Yang Tian, Xujun Ruan, Hao Chen, Xunxun Wu, Xiaowei Xu, Haiping Hao*, Hui Ye*, “Probing Specific Ligand-Protein Interactions by Native-Denaturing Switchable Desorption Electrospray Ionization Mass Spectrometry", Analytica Chimica Acta, 2018,1036,58-65. Jin Wang, Shuyao Zhang, Chang Xu, Lukasz Wojtas, Novruz G. Akhmedov, Hao Chen, Xiaodong Shi,* “Highly Efficient and Stereoselective Thioallylation of Alkynes: Possible Gold Redox Catalysis with No Need of a Strong Oxidant”, Angew. Chem. Int. Ed., 2018, 57, 6915 –6920. Michael Nshanian, Rajeswari Lakshmanan, Hao Chen, Rachel Loo*, Joseph Loo*, “Enhancing Sensitivity of Liquid Chromatography/Mass Spectrometry of Peptides and Proteins Using Supercharging Agents”, Int. J. Mass Spec. 2018, 427, 157-164. Mei Lu, Yijin Su, Pengyi Zhao, Xiaohan Ye, Yi Cai, Xiaodong Shi,* Eric Masson,* Fengyao Li, J. Larry Campbell and Hao Chen*, “Direct Evidence for the Origin of Bis-Gold Intermediates: Probing Gold Catalysis with Mass Spectrometry”, Chemistry - A European Journal, 2018, 24, 2144-2150. Yi Cai, Jiang Wang, Yuexiang Zhang, Zhi Li, David Hu, Nan Zheng*, and Hao Chen*, “Detection of Fleeting Amine Radical Cations and Elucidation of Chain Processes in Visible Light-Mediated [3+2] Annulation by Online Mass Spectrometric Techniques”, J. Am. Chem. Soc., 2017, 139, 12259–12266. Pengyuan Liu, Pengyi Zhao, R. Graham Cooks* and Hao Chen*, “Atmospheric Pressure Neutral Reionization Mass Spectrometry for Structural Analysis”, Chemical Science, 2017, 8, 6499-6507. Si Cheng, Qiuhua Wu*, He Xiao, and Hao Chen*, “Online Monitoring of Enzymatic Reactions Using Time-Resolved Desorption Electrospray Ionization Mass Spectrometry”, Anal. Chem., 2017, 89, 2338–2344. Qiuhua Wu*, Si Cheng, Hao Chen and Chun Wang*, “ZIF-67 templated synthesis of nanoporous carbon as an efficient adsorbent for preconcentration of flunitrazepam from beverage samples”, Food Anal. Methods, 2017, 10, 2772–2780. Zhi Li*, Shuaihua Zhang, Yi Cai, Qiuhua Wu, Hao Chen*, “Hollow fiber-based solid-liquid phase microextraction combined with theta capillary electrospray ionization mass spectrometry for sensitive and accurate analysis of methamphetamine”, Anal. Methods, 2016, 8, 7800-7807. Qiuhua Wu*, Si Cheng, Chenhuan Wang, Xiyang Li, Zhi Li, Hao Chen*, "Magnetic porous carbon derived from bimetallic metal-organic framework: A novel magnetic solid phase extraction adsorbent for flunitrazepam", Microchimica Acta, 2016, 183, 3009-3017. Xiaohan Ye, Chang Xu, Lukasz Wojtas, Novruz Akhmedov, Hao Chen*, Xiaodong Shi* “Silver-Free Palladium Catalyzed sp3 and sp2 C-H Alkynylation Promoted by 1,2,3-Triazole Amine (TAM) Directing Group", Org. Lett., 2016, 18, 2970–2973.