Xu, Ke - University of California, Berkeley

个人简介

Ke Xu is an assistant professor of Chemistry and a Chan-Zuckerberg Biohub Investigator at UC-Berkeley. Ke received his B.S. from Tsinghua University, did his Ph.D. work with Prof. Jim Heath at Caltech, and his postdoc work with Prof. Xiaowei Zhuang at Harvard University. Ke joined the College of Chemistry at UC-Berkeley in the summer of 2013. His current research develops new physicochemical tools to interrogate biological, chemical, and materials systems at the nanoscale with extraordinary resolution, sensitivity, and functionality. To this end, his lab takes a multidimensional approach that integrates advanced microscopy, spectroscopy, cell biology, and nanotechnology. Ke is a Sloan Research Fellow, a Packard Fellow for Science and Engineering, a Beckman Young Investigator, and a Pew Biomedical Scholar, and has received an NSF CAREER Award, an NIH Director's New Innovator Award, and the Talented 12 by C&EN.

研究领域

Multidimensional & multifunctional superresolution microscopy Nanoscale cell biology Graphene microscopy and chemistry

近期论文

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R. Yan, K. Chen, K. Xu*, "Probing nanoscale diffusional heterogeneities in cellular membranes through multidimensional single-molecule and super-resolution microscopy," [Link] J. Am. Chem. Soc.,2020. B. Belardi, T. Hamkins-Indik, A. R. Harris, J. Kim, K. Xu, D. A. Fletcher*, "A weak link with actin organizes tight junctions to control epithelial permeability," [Link] Dev. Cell, 54, 792-804, 2020. T. D. Roberts, R. Yuan, L. Xiang, M. Delor, R. Pokhrel, K. Yang, E. Aqad, T. Marangoni, P. Trefonas, K. Xu, N. S. Ginsberg*, "Direct correlation of single-particle motion to amorphous microstructural components of semicrystalline poly(ethylene oxide) electrolytic films," [Link] J. Phys. Chem. Lett., 11, 4849-4858, 2020. K. J. Wolf, P. Shukla, K. Springer, S. Lee, J. D. Coombes, C. J. Choy, S. J. Kenny, K. Xu, S. Kumar*, "A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles," [Link] Proc. Natl. Acad. Sci. U.S.A., 117, 11432-11443, 2020. S. Moon||, W. Li||, M. Hauser, K. Xu*, "Graphene-enabled, spatially controlled electroporation of adherent cells for live-cell super-resolution microscopy," [Link] ACS Nano, 14, 5609-5617, 2020. L. Xiang||, K. Chen||, R. Yan, W. Li, K. Xu*, "Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity," [Link] Nature Methods, 17, 524-530, 2020. X. Guo, G. Aviles, Y. Liu, R. Tian, B. A. Unger, Y.-H. T. Lin, A. P. Wiita, K. Xu, M. A. Correia, M. Kampmann*, "Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway," [Link] Nature, 579, 427-432, 2020. W. Li, Y. Li, K. Xu*, "Azidated graphene: direct azidation from monolayers, click chemistry, and bulk production from graphite," [Link] Nano Lett., 20, 534-539, 2020. Y. Sun, J. Schöneberg, X. Chen, T. Jiang, C. Kaplan, K. Xu, T. D. Pollard, D. G. Drubin*, "Direct comparison of clathrin-mediated endocytosis in budding and fission yeast reveals conserved and evolvable features,"[Link] eLife, 8, e50749, 2019. L. Xiang, K. Xu*, "Super-resolution writing," [News & Views] [Link] Nature Chem., 11, 969-971, 2019. P. D. Sohn, C. T.-L. Huang, R. Yan, L. Fan, T. E. Tracy, C. M. Camargo, K. M. Montgomery, T. Arhar, S.-A. Mok, R. Freilich, J. Baik, M. He, S. Gong, E. D. Roberson, C. M. Karch, J. E. Gestwicki, K. Xu, K. S. Kosik, L. Gan*, "Pathogenic tau impairs axon initial segment plasticity and excitability homeostasis," [Link] Neuron, 104, 458-470, 2019. J. Kim, M. Wojcik, Y. Wang, S. Moon, E. A. Zin, N. Marnani, Z. L. Newman, J. G. Flannery, K. Xu*, X. Zhang*, "Oblique-plane single-molecule localization microscopy for tissues and small intact animals," [Link] Nature Methods, 16, 853-857, 2019. D. I. Danylchuk||, S. Moon||, K. Xu*, A. S. Klymchenko*, "Tailor-made switchable solvatochromic probes for live-cell super-resolution imaging of plasma membrane organization," [Link] Angew. Chem. Int. Ed., 58, 14920-14924, 2019. Y. Li, W. Li, M. Wojcik, B. Wang, L.-C. Lin, M. B. Raschke, K. Xu*, "Light-assisted diazonium functionalization of graphene and spatial heterogeneities in reactivity," [Link] J. Phys. Chem. Lett., 10, 4788-4793, 2019. R. Yan, B. Wang, K. Xu*, "Functional super-resolution microscopy of the cell," [Invited review] [Link] Curr. Opin. Chem. Biol., 51, 92-97, 2019. L. Pan, P. Zhang, F. Hu, R. Yan, M. He, W. Li, J. Xu, K. Xu*, "Hypotonic stress induces fast, reversible degradation of the vimentin cytoskeleton via intracellular calcium release," [Link] Adv. Sci., 6, 1900865, 2019. T. Kim||, S. Moon||, K. Xu*, "Information-rich localization microscopy through machine learning," [Link] Nature Commun., 10, 1996, 2019. A. A. Polyzos, D. Y. Lee, R. Datta, M. Hauser, H. Budworth, A. Holt, S. Mihalik, P. Goldschmidt, K. Frankel, K. Trego, M. J. Bennett, J. Vockley, K. Xu, E. Gratton, C. T. McMurray*, "Metabolic reprogramming in astrocytes distinguishes region-specific neuronal susceptibility in Huntington mice," [Link] Cell Metab., 29, 1258-1273, 2019. W. Li, M. Wojcik, K. Xu*, "Optical microscopy unveils rapid, reversible electrochemical oxidation and reduction of graphene," [Link] Nano Lett., 19, 983-989, 2019. L. Yuan, S. J. Kenny, J. Hemmati, K. Xu, R. Schekman*, "TANGO1 and SEC12 are copackaged with procollagen I to facilitate the generation of large COPII carriers," [Link] Proc. Natl. Acad. Sci. U.S.A., 115, E12255-E12264, 2018.