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个人简介

教育背景 1992-1997 大连医科大学,医疗系/医学学士 1997-2000 沈阳农业大学/军事医学科学院放射医学研究所,生物化学专业/理学学士 2002-2008 中国科学院大连化学物理研究所/中国科学院研究生院,分析化学专业/理学博士 工作经历 2000-2003中国科学院大连化学物理研究所,国家色谱研究分析中心,实习研究员; 2003-2009中国科学院大连化学物理研究所,国家色谱研究分析中心,助理研究员; 2009-2013中国科学院大连化学物理研究所,国家色谱研究分析中心,副研究员; 2010-2014 美国普度大学,化学系/博士后 2015至今 中国医学科学院药物研究所,国家药物及代谢产物分析研究中心,副研究员。

研究领域

1. 质谱新技术和新型离子源研发 在常压环境下对离子的生成、传输、离子分子反应等过程进行精细调控的新技术研究,以及敞开式离子源的研发。 2. 质谱新技术在医药研发中的应用 1)质谱新技术在药物合成化学中的应用; 2)质谱新技术在药理研究中的应用; 3)质谱新技术用于疾病诊断相关生物标志物的快速分析。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. X. Yan, Ewa Sokol, X. Li, G. Li, R.G. Cooks, “On-line reaction monitoring and mechanistic studies by mass spectrometry: Negishi cross-coupling, hydrogenolysis and reductive amination”, Angew. Chem. Int. Ed., 2014, 53, 5931-5935. 2. X. Yan, R. Augusti, X. Li, R.G. Cooks, “Chemical reactivity assessment using reactive paper spray mass spectrometry: Katritzky reaction”, ChemPlusChem., 2013, 78, 1142-1148. 3. G. Li*, X. Li*, Z. Ouyang, R.G. Cooks, “Carbon–Carbon bond activation in saturated hydrocarbons by field-Assisted nitrogen fixation”, Angew. Chem. Int. Ed., 2013, 152, 1040-1043. (*共同第一作者) 4. J.I. Zhang*, X. Li*, Z. Ouyang, R.G. Cooks, “Direct analysis of steviol glycosides from Stevia leaves by ambient ionization mass spectrometry performed on whole leaves”, Analyst, 2012, 137, 3091-3098. (*共同第一作者) 5. R.J Tian, L.B. Ren, H. Ma, X. Li, L.H. Hu, M.L. Ye, R.A. Wu, Z. Tian, Z. Liu, H.F. Zou, “Selective enrichment of endogenous peptides by chemically modified porous nanoparticles for peptidome analysis”, J. Chromatogr. A, 2009, 1216, 1270-1278. 6. X. Li, S.Y. Xu, Y. Zhang, H.F. Zou, “Label-free Differential Analysis of Peptides by Retention Time Mass-charge Ratio Pairs”, Chin. J. Anal. Chem., 2008, 36, 867-873. 7. X. Li, X.N. Jiang, H.F. Zou, “Identification and relative quantification of peptides by capillary reversed-phase liquid chromatography-tandem mass spectrometry”, Chin. J. Chromatogr., 2008, 26, 189-194. 8. X. Li, S.Y. Xu, C.S. Pan, H.J. Zhou, Xiaogang Jiang, Y. Zhang, M.L. Ye, H.F. Zou, “Enrichment of peptides from plasma for peptidome analysis using multiwalled carbon nanotubes”, J. Sep. Sci., 2007, 30, 783-948.(Cover paper) 9. L.H. Hu, X. Li, X.N. Jiang, H.J. Zhou, X.G. Jiang, L. Kong, M.L. Ye, H.F. Zou, “Comprehensive peptidome analysis of mouse livers by size exclusion chromatography prefractionation and nanoLC-MS/MS identification”, J. Proteome Res., 2007, 6, 801-808. 10. J.J. Ou, X. Li, S. Feng, J. Dong, X.L. Dong, L. Kong, M.L. Ye, H.F. Zou, “Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography”, Anal. Chem., 2007, 79, 639-646. 11. R.J Tian, H. Zhang, M.L. Ye, X.G. Jiang, L.H. Hu, X. Li, X.H. Bao, H.F. Zou, “Selective extraction of peptides from human plasma by highly ordered mesoporous silica particles for peptidome analysis”, Angew. Chem. Int. Ed., 2007, 46, 962-965. 12. H.J. Zhou, R.J Tian, M.L. Ye, S.Y. Xu, S. Feng, C.S. Pan, X.G. Jiang, X. Li, H.F. Zou,“Highly specific enrichment of phosphopeptides by zirconium dioxide nanoparticles for phosphoproteome analysis”, Electrophoresis, 2007, 28, 2201-2215. 13. R.J Tian, M.L. Ye, L.H. Hu, X. Li, H.F. Zou, “Selective extraction of peptides in acidic human plasma by porous silica nanoparticles for peptidome analysis with 2-D LC-MS/MS”, J. Sep. Sci., 2007, 30, 2204–2209.

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