研究领域
1. 基于NMR技术代谢组学在心脑血管创新药物的发现、评价和成药性等关键环节应用研究
以系统生物学和转化医学研究理念为指导，利用基于NMR技术代谢组学对心血管疾病动物模型、临床病人及药物干预组织及生物体液代谢特点进行研究。上述工作已发表论文12篇。
2. 复杂混合物系统微量物质结构分析
利用HPLC-NMR联用技术，鉴定了天然产物，药物杂质，生物代谢物等五十多个样品。并确定了代谢产物代谢、排泄途径，为其作用机理的阐明提供了一定依据。上述工作已发表论文12篇。
3. 蛋白质溶液结构分析及生物大分子与药物小分子相互作用研究
用2D NMR图谱开展了蝎毒溶液结构分析研究，同时采用NMR饱和转移差谱方法（STD）精确测定药物小分子的结合位点，并确定药效分子群中能够结合到靶蛋白的化合物及其结合能力，从一定程度上阐明药物小分子与靶蛋白相互作用机理。这方面的工作有BACE1与抑制剂AV-4-1的STD-NMR研究；AMPK与新型调血脂药物候选化合物WS070117的STD-NMR研究。
近期论文
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1. Zhaoxia Miao, Mengxia Jin, Xia Liu, Wei Guo, Xiangju Jing, Hongyue Liu, Yinghong Wang*. The application of HPLC and NMR spectroscopy in the identification of metabolites in complex biological matrices. Analytical and Bioanalytical Chemistry. 2015, 407(12), 3405-3416. SCI: 3.578
2. Wei Guo, Mengxia Jin, Zhaoxia Miao, Xia Liu, Xiangju Jing, Hongyue Liu, Yinghong Wang*. Structure elucidation of the metabolites of 2', 3', 5'-tri-O-acetyl-N6-(3-hydroxyphenyl) adenosine in rat urine by HPLC-DAD, ESI-MS and off-line microprobe NMR. PLoS ONE. 2015, 10 (6): e0127583. SCI: 3.234
3. Qingyun Yang, Hui Qiu, Wei Guo, Dongmei Wang, Xingning Zhou, Dan Xue, Jinlan Zhang, Song Wu * and Yinghong Wang *. Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets. Molecules. 2015, 20: 12114-12124. SCI: 2.416
4. Chunying Jiang, Kangmin Yang, Liu Yang, Zhaoxia Miao, Yinghong Wang*, Haibo Zhu*. 1H NMR-based metabonomic studies on urine and plasma metabolic time-related trajectory of hyperlipidemic hamsters. PLoS ONE. 2013, 8(6): e66786. SCI: 3.534
5. Yuanyan Liu, Zeqin Lian, Yinghong Wang*, Shishan Yu*, Haibo Zhu. A systematic, integrated study on the neuroprotective effects of hydroxysafflor yellow A based on 1H NMR-based metabonomics and the NF-κB pathway, Evidence-Based Complementary and Alternative Medicine (eCAM). Volume 2013, Article ID 147362, 14 pages. http://dx.doi.org/10.1155/2013/147362. SCI: 2.175
6. Yang Sun, Zeqin Lian, Chunying Jiang, Yinghong Wang*, Haibo Zhu*. Beneficial metabolic effects of 2′, 3′, 5′-triacetyl-N6-(3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters. PLoS ONE. 2012, 7(3): e32115. SCI: 4.092
7. Yong Li, Xianfu Wu, Jianbei Li, Haining Lv, Qu Jing, Abliz Zeper, Jing Liu, Yuanyan Liu, Dan Du, Yinghong Wang*, Shishan Yu*. Identification of cardiac glycosides in fractions from periploca forrestii by high-performance liquid chromatography/diode-array detection/electrospray ionization multistage tandem mass spectrometry and liquid chromatography/nuclear magnetic resonance. Journal of Chromatography B. 2010, 878: 381–390. SCI: 2.500
8. Yang Sun, Yinghong Wang*, Kai Qu, Haibo Zhu*. Beneficial effects of cordycepin on metabolic profiles of liver and plasma from hyperlipidemic hamsters. Journal of Asian Natural Products Research. 2011, 13(6): 534-546. SCI: 0.897
9. 江春迎, 杨康敏, 杨柳, 苗朝霞, 朱海波, 王映红*. 金黄地鼠动脉粥样硬化发展过程中血浆NMR代谢组学研究. Acta Pharmaceutica Sinica. 2013, 48 (4): 495-502.
10. 苗朝霞, 王映红*. NMR技术在天然产物活性物质发现及其药理学研究中的应用. Acta Pharmaceutica Sinica. 2013, 48 (9): 1383-1389.
11. Jingyan Li, Chunyan Ma, Hongyuan Wang, Yinghong Wang, Linzhuan Wu, Yiguang Wang*. On-line identification of 4-isovalerylspiramycin I in the genetic engineered strain of S. spiramyceticus F21 by liquid chromatography with electrospray ionization tandem mass spectrometry, ultraviolet absorbance detection and nuclear magnetic resonance spectrometry. Journal of Chromatography A. 1217 (2010): 1419-1424. SCI: 3.756
12. Xiaoyan Tian, Yinghong Wang, Qingyun Yang, Shishan Yu, Weishuo Fang*. Jacaranone analogs from senecio scandens. Journal of Asian Natural Products Research. 2009, 11(1): 63-68. SCI: 0.897
13. Jing Qu#, Yinghong Wang#, Jianbei Li, Yuan Li, Yunbao Liu, Shishan Yu*. Rapid structural determination of new trace cassaine-type diterpenoid amides in fractions from erythrophleum fordii by liquid chromatography-dioe-array detection/electrospray ionization tandem mass spectrometry and liquid chromatography/nuclear magnetic resonance. Rapid Communications in Mass Spectrometry. 2007, 21: 2109-2119. SCI: 2.772
14. Jing Qu, Youcai Hu, Jianbei Li, Jinlan Zhang, Abliz Zeper, Yunbao Liu, Yinghong Wang , Shishan Yu*. Structural characterization of constituents with molecular diversity in fractions from lysidice brevicalyx by liquid chromatoraphy/diode-Array detection/electrospray ionization tandem mass spectrometry and liquid chromatoraphy/nuclear nagnetic resonance. Rapid Communications in Mass Spectrometry. 2008, 22: 755-765. SCI: 2.772
15. Feng Feng, Wenyuan Yu, Yinghong Wang, Qinglan Gao, Qidong You*. Structure elucidation of metabolites of gambogic acid in vivo in rat bile by high performance liquid chomatography-mass spectrometry and high performance liquid chomatography-nuclear magnetic resonance. Journal of Chromatography B. 2007, 860: 218-226. SCI: 2.935
16. Jing Zhang, Liang Zhang, Suode Zhang, Yinghong Wang, Gang Liu. Solution-Phase parallel synthesis of a 1, 2, 7-trialkyl-1H-imidazo [4, 5-g] quinoxalin-6-ol Library Scaffold. Journal of Combinatorial Chemistry. 2005, 7: 657-664 SCI: 3.459
17. YingHong Wang, ZhengYu Cao, WenYi He, Xing Liu, HongYue Liu, DeQuan Yu*. 1H-NMR signal assignment and secondary structure analysis of martentoxin. Journal of Asian Natural Products Research. 2006, 8(6): 511-518. SCI: 0.897
18. Gang Ni, Zhufang Shen, Yang Lv, Yinghong Wang, Yanbo Tang, Ruoyun Chen, Zhiyou Hao, Dequan Yu*. Glucokinase-activating sesquinlignans from the rhizomes of acorus tatarinowii schott. Journal of Organic Chemistry. 2011, 76: 2056-2061. SCI: 4.45
19. Jiaming Wang, Guangzhi Ding, Lei Fang, Jungui Dai, Xiaoguang Chen, Shuanggang Ma, Jing Qu, Hao Xu, Yinghong Wang, Shishan Yu*. Thiodiketopiperazines produced by the endophytic fungus epicoccum nigrum. Journal of Natural Products. 2010, 73: 1240-1249. SCI: 3.128
20. Gang Ni, Qingjian Zhang, Yinghong Wang, Ruoyun Cheng, Chongfei Zhong, Dequan Yu*. Chemical constituents of the stem bark of morus cathayana. Journal of Asian Natural Products Research. 2010, 12(6): 505-515. SCI: 0.897
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