Dubikovskaya, Elena - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Elena Dubikovskaya has been appointed Tenure Track Assistant Professor of bio-organic chemistry at the School of Basic Sciences (FSB). She received her MS degree from University of Central Florida under supervision of D. Howard Miles in the field of medicinal chemistry of natural products. She then continued her PhD studies in the field of medicinal chemistry and drug delivery in the group of Professor Paul Wender at Stanford University. After graduation with a PhD degree in 2008, she moved to University of California at Berkeley where she did her postdoctoral studies in the field of Chemical Biology in the group of Carolyn Bertozzi.

研究领域

Professor Dubikovskaya is an advocate of an interdisciplinary approach, combining synthetic chemistry, optical imaging, and an understanding of cellular functions at molecular level to find solutions to fundamental problems in biology and medicine. This scientist has developed, in particular, several new non-invasive imaging techniques that allow studies of molecular signatures of cancer and metabolic diseases. She will perform her research work in the context of the new Chair in biological chemistry, at EPFL’s Institute of Chemical Sciences and Engineering.

近期论文

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Dubikovskaya, E.; Chudnovskiy, R.; Karateev, G.; Park, H. M.; Stahl, A. Measurement of Long-Chain Fatty Acid Uptake into Adipocytes. Methods in Enzymology, 2014, 538, 107-134. http://www.sciencedirect.com/science/article/pii/B9780128002803000074 Godinat, A.; Park, H. M.; Miller, S. C.; Cheng, K.; Hanahan, D.; Sanman, L. E.; Bogyo, M.; Yu, A.; Nikitin, G. F.; Stahl, A.; Dubikovskaya, E. A. A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice. ACS Chemical Biology 2013, 8, 987–999. pubs.acs.org/doi/abs/10.1021/cb3007314 Van de Bittner, G. C.; Dubikovskaya, E. A.; Bertozzi, C. R.; Chang, C. J. In vivo Imaging of Hydrogen Peroxide Production in a Murine Tumor Model with a Chemoselective Bioluminescent Reporter. Proceedings of the National Academy of Sciences of the USA, 2010, 107, 21316-21321. www.pnas.org/content/107/50/21316.full.pdf+html Cohen, A. S.; Dubikovskaya, E. A.; Rush, J. S.; Bertozzi, C. R. Real-Time Bioluminescence Imaging of Glycans on Live Cells. Journal of the American Chemical Society, 2010, 132, 8563-8565. pubs.acs.org/doi/abs/10.1021/ja101766r Dubikovskaya, E. A.; Thorne, S. H.; Pillow, T. H.; Contag, C. H.; Wender, P. A. Overcoming Multidrug Resistance of Small Molecule Therapeutics Through Conjugation with Releasable Octaarginine Transporters. Proceedings of the National Academy of Sciences of the USA, 2008, 105, 12095-12096. www.pnas.org/content/105/34/12128.full.pdf+html Lee, H.-L.; Dubikovskaya, E. A.; Hwang, H.; Semyonov, A. N.; Wang, H.; Jones, L. R.; Twieg, R. J.; Moerner, W. E.; Wender, P. A. Single-Molecule Motions of Oligoarginine Transporter Conjugates on the Plasma Membrane of CHO Cells. Journal of the American Chemical Society, 2008, 130, 9364-9370. pubs.acs.org/doi/abs/10.1021/ja710798b Publications under previous name (Goun) Wender, P. A.; Galliher, W. C.; Goun, E. A.; Jones, L. R.; Pillow, T. H. The Design of Guanidinium-Rich Transporters and Their Internalization Mechanisms. Advanced Drug Delivery Reviews, 2008, 60, 452-472. Wender, P. A.; Goun, E. A.; Jones, L. R.; Pillow, T. H.; Rothbard, J. B.; Shinde, R.; Contag, C. H. Real-time Analysis of Uptake and Bioactivatable Cleavage of Luciferin-Transporter Conjugates in Transgenic Reporter Mice. Proceedings of the National Academy of Sciences of the USA, 2007, 104, 10340-10345. Jones, L. R.; Goun, E. A.; Shinde, R.; Rothbard, J. B.; Contag, C. H.; Wender, P. A. Releasable Luciferin-Transporter Conjugates: Tools for the Real-Time Analysis of Cellular Uptake and Release. Journal of the American Chemical Society, 2006, 128, 6526-6527. - Goun, E. A.; Pillow, T. H.; Jones, L. R.; Rothbard, J. B.; Wender, P. A. Molecular Transporters: Synthesis of Oligoguanidinium Transporters and their Application to Drug Delivery and Real Time Imaging. ChemBiochem, 2006, 7, 1497-1515.