个人简介
教育背景：
2000.09 ~ 2005.07 首都医科大学，预防医学专业，医学学士
2005.09 ~ 2010.07 清华大学医学部&北京协和医学院药物研究所，药理学，医学博士
工作经历：
2010.09 ~ 2012.04，中国医学科学院药物研究所，药理系，助理研究员
2012.04 ~ 2012.07，美国弗吉尼亚大学，肾脏病及免疫炎症再生医学系，访问学者
2012.07 ~ 2014.07，中国医学科学院药物研究所，药理系，助理研究员
2014.07-，中国医学科学院药物研究所，药理系，副研究员
研究领域
主要从事自身免疫性疾病及肿瘤免疫学的药理学研究及新药临床前开发。
近期论文
查看导师新发文章
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1. Jing Jin, Jinping Hu, Wanqi Zhou, Xiaojian Wang, Qiong Xiao, Nina Xue, Dali Yin, Xiaoguang Chen. Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis. Biochemical Pharmacology. 2014, Jul 1; 90(1), 50-61.
2. Jin Jing, Zhang Yi, Li Yan, Zhang Haijing, Li Hongyan, Yuan Xia, Li Xiangyan, Zhou Wanqi, Xu Bailing, Zhang Chongjing, Zhang Zhihui, Zhu Lina, Chen Xiaoguang. RNA-interference-mediated downregulation of Pin1 suppresses tumoriigenicity of malignant melanoma A375 cells. Neoplasma. 2013, 60(1): 92-100.
3. Tian Yulin1, Jin Jing1, Wang Xiaojian, Hu Jinping, Xiao Qiong, Zhou Wanqi, Chen Xiaoguang, Yin Dali. Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design. Eur J Med Chem. 2014, Oct 6;85:1-15. (Co-First Author)
4. Jie Zhou1, Jing Jin1, Yi Zhang, Yuwen Yin, Xiaoguang Chen, Bailing Xu. Synthesis and antiproliferative evaluation of novel benzoimidazole contained oxazole-bridged analogs of combretastatin A-4.Eur J Med Chem. 2013, Oct; 68:222-232 (Co-First Author)
5. Chang Liu1, Jing Jin1, Liang Chen, Jie Zhou, Xiaoguang Chen, Decai Fu, Hongrui Song, Bailing Xu. Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorg Med Chem. 2012, 20(9): 2992-2999. (Co-First Author)
6. Yongkang Wang1, Jing Jin1, Lina Zhu, Yi Zhang, Xiaoguang Chen, Xinqin Gao, Bailing Xu. Synthesis and antitumor activity of novel 2-(1-substitutedpiperidin- 4-ylamino)quinazolines as antitumor agents. Acta Pharmaceutica Sinica B. 2012, 47(9):1164-1178 (Co-First Author)
7. Jing Jin, Li-na Zhu, Hai-jing Zhang, Yan Li, Yi Zhang, Wan-qi Zhou, Bai-ling Xu, Xiao-guang Chen. XLN306 induces apoptosis in human breast carcinoma MX-1 cells. Acta Pharmaceutica Sinica B. 2011, 1(2):84-88.
8. Zhu Lina1, Jin Jing1, Liu Chang, Zhang Chongjing, Sun Yan, Chen Xiaoguang, Xu Bailing. Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors. Bioorg Med Chem. 2011, 19(9):2797-807. (Co-First Author)
9. 金晶，张海婧，汪小涧，周琬琪，扈金萍，尹大力，陈晓光.新型免疫抑制剂SYL934的抗皮肤移植排斥反应研究.中国药理学通报.2014, 30(6):763-773.
10. 金晶，汪小涧，周琬琪，薛妮娜，尹大力，陈晓光.新型前药类S1P1激动剂Sy1978的药理活性.中国药科大学学报.2014, 45(3) :358-361.
11. 席月月1，金晶1，孙艳，陈晓光，宋宏锐，徐柏玲. 新型含嘧啶环二芳基醚类Pin1抑制剂的设计、合成及活性评价. 药学学报. 2013, 48(8): 1266 −1272.
12. 金晶，张海婧，汪小涧，周琬琪，尹大力，陈晓光.新型S1P1受体激动剂Sy1948抗皮肤移植排斥反应研究.药学学报.2014, 49(5):627-631.
13. Zhang L, Jin J, Zhang L, et al. Quantitative analysis of differential protein expression in cervical carcinoma cells after zeylenone treatment by stable isotope labeling with amino acids in cell culture. J Proteomics. 2015, Aug 3;126:279-87.
14. Xue nina, Jin Jing, Liu Di, et al. Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways. Curr Cancer Drug Targets. 2014, 14(7):671-83.
15. Zhu Zhixiang, Jin Jing, Xue Nina, et al. Development and validation of high-throughput screening assays for poly(ADP-ribose) polymerase-2 inhibitors. Anal Biochem. 2014, Mar 15;449:188-94.
16. Haijing Zhang, Jing Jin, Wanqi Zhou, et al. Nicousamide, a potent inhibitor of phosphorylation by TGF-b receptor II. Acta Pharmaceutica Sinica B. 2011, 1(3):160–165.
17. 李康宁，金晶，陈晓光. 膜联蛋白A1增加人慢性髓系白血病细胞K562对伊马替尼的敏感性.药学学报. 2013, 48 (6): 866 −873.
18. Miao J, Cui H, Jin J, Lai F, Wen H, Zhang X, Ruda GF, Chen XG, Yin D. Development of 3-alkyl-6-methoxy-7-hydroxy-chromones(AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging. Chem Commue (Camb). 2015, 18;51(5):881-4.
19. Chunwan Lu, Di Liu, Jing Jin, Hemantkumar Deokar , Yi Zhang , John K. Buolamwini ,Xiaoming Yu , Chunhong Yan , Xiaoguang Chen . Inhibition of gastric tumor growth by a novel Hsp90 inhibitor. Biochemical Pharmacology 2013,85:1246–1256.
20. Sen Z, Zhan XK, Jing J, et al. Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells. Oncol Lett, 2013, Feb;5(2):641-644.
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