个人简介
教育背景：
2006.09-2009.07， 北京协和医学院， 药理学， 博士
2002.09-2005.07， 成都中医药大学， 药理学， 硕士
1997.09-2002.07， 成都中医药大学， 中药药理， 学士
工作经历：
2015.09 至今 中国医学科学院&北京协和医学院，药物研究所，副研究员；
2014.01-2015.09 英国曼彻斯特大学 Faculty of Life Sciences，博士后；
2009.08-2015.08 中国医学科学院&北京协和医学院，药物研究所，助理研究员。
研究领域
主要兴趣为基于重要细胞器内质网与线粒体的系统整合研究，从未折叠蛋白反应（Unfolded protein response, UPR)、线粒体相关内质网膜（Mitochondria-associated ER membrane, MAM）和线粒体动态调控等方向，探讨调控细胞功能的重要基因和蛋白质，寻找防治心脑血管疾病的新靶点和药物。
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
1. Shoubao Wang, Zhenzhong Wang, Qiru Fan, Jing Guo, Galli G, Guanhua Du, Xin Wang, Wei Xiao. Ginkgolide K protects the heart against ER stress injury by activating IRE1α/XBP1 pathway. Br J Pharmacol. 2016 May 17. doi: 10.1111/bph.13516.
2. Rui Zhao，Shoubao Wang，Zhonglin Huang，Li Zhang，Xiuying Yang，Xiaoyu Bai，Dan Zhou，Zhizhen Qin，Guanhua Du. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Biosci Trends. 2015 Dec;9(6):367-76.
3. Yu Yan, Yu-Cai Chen, Yi-Huang Lin, Jing Guo, Zi-Ran Niu, Li Li, Shoubao Wang, Lian-Hua Fang, Guan-Hua Du. Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and -independent relaxation of rat aortic rings. Acta Pharmacol Sin. 2015 Nov;36(11):1318-26.
4. Ran-Yao Yang, Gang Zhao, Dong-Mei Wang, Xiao-Cong Pang, Shoubao Wang, Jian-Song Fang, Chao Li, Ai-Lin Liu, Song Wu, Guan-Hua Du. DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice. Pharmacol Biochem Behav. 2015 Dec;139(Pt A):15-26.
5. Xu XN, Niu ZR, Shoubao Wang, Chen YC, Gao L, Fang LH, Du GH. Effect and mechanism of total flavonoids of bugloss on rats with myocardial ischemia and reperfusion injury. Yao Xue Xue Bao. 2014, 49(6):875-881.
6. Guo J, Li L, Wu YJ, Yan Y, Xu XN, Shoubao Wang, Yuan TY, Fang LH, Du GH. Inhibitory Effects of Brazilin on the Vascular Smooth Muscle Cell Proliferation and Migration Induced by PDGF-BB. Am J Chin Med. 2013;41(6):1283-96.
7. Li L, Pang XB, Chen BN, Gao L, Wang L, Shoubao Wang, Wang SB, Liu DP, Du GH. Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca2+]i and ERK1/2 activation through blocking AT1R in the rat aorta. Biochem Biophys Res Commun. 2013 May 24;435(1):69-75.
8. Shoubao Wang, Pang Xiao-Bin, Gao Mei, Fang Lian-Hua, Du Guan-Hua. Pinocembrin protects rat against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids. Chinese Journal of Natural Medicines. 2013, 11(3):0207-13.
9. Shoubao Wang, Wei-Ku Zhang, Xiao-Bin Pang, Li Li, Guo-Rong He, Xiu-Ying Yang, Lian-Hua Fang, Guan-Hua Du. EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway. Acta Pharmaceutica Sinica B. 2013, 3(1): 25–31.
10. Shoubao Wang, Xiao-Bin Pang, Yan Zhao, Yue-Hua Wang, Li Zhang, Xiu-Ying Yang, Lian-Hua Fang, Guan-Hua Du. Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. J Asian Nat Prod Res. 2012, 14(11): 1084-92.
11. Guo J, Shoubao Wang, Yuan TY, Wu YJ, Yan Y, Li L, Xu XN, Gong LL, Qin HL, Fang LH, Du GH. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis. 2013 Dec;231(2):384-91.
12. Gong Li-Li, Fang Lian-Hua, Wang Su-Bo, Sun Jia-Lin, Qin Hai-Lin, Li Xiao-Xiu, Shoubao Wang, Du Guan-Hua. Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis. 2012; 222(1):50-8.
13. Bainian Chen, Lili Shi, Xiaoyan Yu, Jialin Sun, Hengai Zhang, Shoubao Wang, Lianhua Fang, Guanhua Du. Differential effects of Rho-kinase inhibitor and angiotensin II type-1 receptor antagonist on the vascular function in hypertensive rats induced by chronic l-NAME treatment. Acta Pharmaceutica Sinica B, 2012; 2(5):450-45.
14. Heng-ai Zhang, Mei Gao, Li Zhang, Yan Zhao, Li-li Shi, Bai-nian Chen, Yue-hua Wang, Shoubao Wang, Guan-hua Du. Salvianolic acid A protects human SH-SY5Y neuroblastoma cells against H2O2-induced injury by increasing stress tolerance ability. Biochem Biophys Res Commun. 2012 May 11;421(3):479-83.
15. Tian Shuo, Du Li-Da, Shoubao Wang, HE Guo-Rong, Yang Tao, Li Xiao-Xiu, Guo Jing, Du Guan-Hua. Pharmacokinetic Study of Baicalein and Its Major Metabolites after iv Administration in Dogs. Chinese Herbal Medicines. 2011; 03(3): 196-201.
16. Zhao Y, Chen BN, Shoubao Wang, Wang SH, Du GH. Vasorelaxant effect of formononetin in the rat thoracic aorta and its mechanisms. J Asian Nat Prod Res. 2012 Jan;14(1):46-54.
17. Yang XY, Qiang GF, Zhang L, Zhu XM, Shoubao Wang, Sun L, Yang HG, Du GH. Salvianolic acid A protects against vascular endothelial dysfunction in high-fat diet fed and streptozotocin-induced diabetic rats. J Asian Nat Prod Res. 2011 Oct;13(10):884-94.
18. Pang XB, Xie XM, Shoubao Wang, Du GH. High-throughput screening of human soluble protein tyrosine phosphatase 1B inhibitors. Yao Xue Xue Bao. 2011 Sep;46(9):1058-64.
19. Shoubao Wang, Yang Xiu-Ying, Tian Shuo, Yang Hai-Guang, Du Guan-Hua. Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats, Life Sci. 2010 Sep 23;85(13-14):499-504.
20. Shoubao Wang, Tian Shuo, Yang Fan, Yang Hai-guang, Yang Xiu-ying, Du Guan-hua. Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. Eur J Pharmacol. 2009; 615(1-3):125-32.
京公网安备 11010802027423号