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个人简介

教育背景: 1991.09 – 1996.07 重庆医科大学,医学检验系,医学学士 1996.09 – 1999.07 重庆医科大学,基础医学院,医学硕士 2005.09 – 2009.01 中国医学科学院&北京协和医学院,基础医学研究所,生物化学与分子生物学系,理学博士 工作经历: 1999.07 – 2005.08 北京世纪坛医院 检验科,医师 2009.08 – 2010.11 中国医学科学院&北京协和医学院 药物研究所,主治医师资格 2010.12 – 2014.08 中国医学科学院&北京协和医学院 药物研究所,助理研究员 2014.09 – 至今 中国医学科学院&北京协和医学院 药物研究所,副研究员

研究领域

主要从事围绕心脑血管疾病及血管功能调节等克隆、表达分子相关靶点,并进行靶点确证研究,以及心脑血管疾病先导化合物的筛选、评价及机制研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Gang Zhao, Wen Zhang, Li Li, Song Wu, Guan-Hua Du (*). Pinocembrin Protects the Brain against Ischemia-Reperfusion Injury and Reverses the Autophagy Dysfunction in the Penumbra Area. Molecules, 2014, 19:15786-15798. 2. Tian-Yi Yuan, Yu Yan, Yu-Jie Wu, Xiao-Na Xu, Li Li , Xiao-Zhen Jiao, Ping Xie , Lian-Hua Fang(*), Guan-Hua Du(*). Vasodilatory Effect of a Novel Rho-Kinase Inhibitor, DL0805-2, on the rat Mesenteric Artery and its Potential Mechanisms. Cardiovasc Drugs Ther, 2014, 28:415–424. 3. Peng Gao, Ting-Ting Xu, Jie Lu, Li Li, De-Long Hao, Hou-Zao Chen, De-Pei Liu(*). Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice. Journal of Molecular Medicine, 2014, 92(4):347-357. 4. Jing Guo, Li Li, Yu-Jie Wu, Yu Yan, Xiao-Na Xu, Shou-Bao Wang, Tian-Yi Yuan, Lian-Hua Fang(*), Guan-Hua Du(*). Inhibitory Effects of Brazilin on the Vascular Smooth Muscle Cell Proliferation and Migration Induced by PDGF-BB. The American Journal of Chinese Medicine, 2013, 41: 1-14. 5. Li Li, Xiao-Bin Pang, Bia-Nian Chen, Li Gao, Le Wang, Shou-Bao Wang, Su-Bo Wang, De-Pei Liu, Guan-Hua Du(*). Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca2+]i and ERK1/2 activation through blocking AT1R in the rat aorta. Biochemical and Biophysical Research Communications, 2013, 435(1):69-75. 6. Li Li, Hai-Guang Yang, Tian-Yi Yuan, Yan Zhao, Guan-Hua Du(*). Rho kinase inhibition activity of pinocembrin in rat aortic rings contracted by angiotensin II. Chinese Journal of Natural Medicines, 2013, 11(3):258-263. 7. Jing Guo, Shou-Bao Wang, Tian-Yi Yuan, Yu-Jie Wu, Yu Yan, Li Li, Xiao-Na Xu, Li-li Gong, Hai-lin Qin, Lian-Hua Fang(*), Guan-Hua Du(*). Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis, 2013, 231(2):384-391. 8. Xu Huan-Li, Yu Jin-Mei, Sun Yan, Xu Xiao-Na, Li Li, Xue Ming, Du Guan-Hua(*). Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose 5-fluorouracil through induction of apoptosis and metabolism. Phytomedicine, 2013, 20(10):897-903. 9. Wei Zheng, Yun-Biao Lu, Shu-Ting Liang, Qing-Jun Zhang, Jing Xu, Zhi-Gang She, Zhu-Qin Zhang, Rui-Feng Yang, Bei-Bei Mao, Zhen Xu, Li Li, De-Long Hao, Jie Lu, Yu-Sheng Wei, Hou-Zao Chen, De-Pei Liu(*). SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes. Basic Res Cardiol, 2013, 108(4):364. 10. Li Li(#), Hui-Na Zhang(#), Hou-Zao Chen(#), Peng Gao, Li-Hua Zhu, Hong-Liang Li, Xiang Lv, Qin-Jun Zhang, Ran Zhang, Zhao Wang, Zhi-Gang She, Ran Zhang, Yu-Sheng Wei, Guan-Hua Du, De-Pei Liu(*), Chih-Chuan Liang. SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circulation Research, 2011, 108:1180-1189. 11. Li Li, Peng Gao, Hui-Na Zhang, Hou-Zao Chen, Wei Zheng, Xiang Lv, Ting-Ting Xu, Yu-ShengWei , De-Pei Liu(*), Chih-Chuan Liang. SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy. Acta Biochim Biophys Sin, 2011, 43: 103–109. 12. 侯碧玉, 李 莉, 张 莉(*), 杜冠华(*),SIRT1 在糖尿病肾病防治中的作用,药学学报,2014, 49 (12): 1625 −1630。 13. 李莉,郭晶,袁天翊,陈柏年,方莲花,宫丽丽,杜冠华(*),Rho激酶抑制剂DL0805对血管紧张素Ⅱ刺激的大鼠离体胸主动脉环的舒张作用及机制研究,中国药理学通报,2013, 29(10):1355-1359。 14. Li Li(#), Peng Gao(#), Hou-Zao Chen, Zhu-Qin Zhang, Ting-Ting Xu, Yu-Yan Jia, Hui-Na Zhang, Guan-Hua Du, De-Pei Liu(*). Up-regulation of Fas Ligand Expression by Sirtuin 1 in both Flow-restricted Vessels and Serum-stimulated Vascular Smooth Muscle Cells. Chinese Medical Sciences Journal, 2013, 28(2):65-71. 15. 李莉,袁天翊,杨海光,许焕丽,王乐,阎雨,杜冠华(*),ERK1/2及JNK参与DL0805抑制血管紧张素II引起的大鼠离体胸主动脉环收缩,基础医学与临床, 2013, 33(6): 699-703。 16. 李莉,袁天翊,郭晶,方莲花,杨海光,张莉,杜冠华(*), DL0805抑制血管紧张素Ⅱ通过Ca2+依赖和非Ca2+依赖途径引起的大鼠胸主动脉环收缩,首都医科大学学报, 2013, 34(3): 398-403。 17. Shou-Bao Wang, Wei-Ku Zhang, Xiao-Bin Pang, Li Li, Guo-Rong He, Xiu-Ying Yang, Lian-Hua Fang, Jun-Tian Zhang, Guan-Hua Du(*). EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway. Acta Pharmaceutica Sinica B, 2013, 3(1):25-31. 18. 王月华,杨海光,李莉,郭晶,童元峰,吴松,杜冠华(*), 昂丹斯琼杂质的小鼠急性毒性和细胞毒性研究,中国药物警戒,2012,9(12):707-709。

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