张晓伟 - 中国医学科学院药物研究所 -

个人简介

教育背景： 1999.09 – 2003.07 沈阳药科大学工商管理学院，管理学学士 2003.09 – 2006.07 沈阳药科大学药学院，药理学硕士 2006.09 – 2009.07 中国医学科学院&北京协和医学院药物研究所，药理学博士工作经历： 2009.09 – 2013.06 美国辛辛那提大学医学院药理及细胞生物物理系，博士后 2013.08 – 2014.08 中国医学科学院&北京协和医学院药物研究所，助理研究员 2014.09 - 今中国医学科学院&北京协和医学院药物研究所，副研究员

研究领域

主要从事具有调节细胞自噬活性的小分子多肽以及天然产物活性分子在糖尿病性心肌病发病过程中的作用和机制研究。

近期论文

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1. Wang XH†, Zhang XW†, Ren XP, Chen J, Liu HZ, Yang JQ, Medvedovic M, Hu ZW, Fan GC*. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/ reperfusion-induced cardiac injury. Circulation, 122(13):1308-18, 2010 († co-first author, IF:14.432) 2. Zhang XW, Wang XH, Zhu HY, Zhu C, Wang YG, Pu WT, Jegga AG, Fan GC*. Synergistic effects of the GATA4- mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol, 49(5):841-50, 2010（IF:5.499） 3. Cai WF†, Zhang XW†, Yan HM, Ma YG, Wang XX, Yan J, Xin BM, Lv XX, Wang QQ, Wang ZY, Yang HZ, Hu ZW*. Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice. Cardiovasc Res, 88(1):140-9, 2010 († co-first author, IF:6.051) 4. Zhang XW, Wang XH, Zhu HY, Kranias EG, Tang YL, Peng TQ, Chang J, Fan GC*. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PLoS One, 7(3):e32765, 2012 (IF:3.730) 5. Ma YG†, Zhang XW†, Bao HY, Mi S, Cai WF, Yan HM, Wang QQ, Wang ZY, Yan J, Fan GC, Lindsey ML, Hu ZW*. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS One, 7(7):e40763, 2012 († co-first author, IF:3.730) 6. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, and Hu ZW*. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nature Communications. In press. (IF=11.47) 7. Yan HM, Cui Bing, Zhang XW, Fu XM, Yan J, Wang XX, Lv XX, Chen Z, Hu ZW*. Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm. Acta Pharmaceutica Sinica B, 45(3), 2015 8. Wang XH, Zhu HY, Zhang XW, Liu Y, Chen J, Medvedovic M, Li HL, Weiss MJ, Ren XP, Fan GC*. Loss of the miR-144/451 cluster impairs ischaemic preconditioning- mediated cardioprotection by targeting Rac-1. Cardiovasc Res, 94(2):379-90, 2012 (IF:6.051) 9. Ma YG, Zhang XW, Bao HY, Yu SS, Hu ZW, Sun W. Blocking extracellular HMGB1 activity protects against doxorubicin induced cardiac injury in mice. Yao Xue Xue Bao, 47(11):1489-1495, 2012. 10. Yan J, Wang ZY, Yang HZ, Liu HZ, Mi S, Lv XX, Fu XM, Yan HM, Zhang XW, Zhan QM, Hu ZW*. Timing is critical for an effective anti-metastatic immunotherapy: the decisive role of IFNγ/STAT1-mediated activation of autophagy. PLoS One, 6(9):e24705, 2011 11. Wang QQ, Yang HZ, Liu HZ, Mi S, Zhang XW, Yan HM, Ma YG, Wang XX, Hu ZW*. Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation. Acta Pharmacol Sin, 32(8):1045-54, 2011 12. Xin BM, Wang XX, Jin W, Yan HM, Cui B, Zhang XW, Hua F, Yang HZ, Hu ZW*. Activation of Toll-like receptor 9 attenuates unilateral ureteral obstruction-induced renal fibrosis. Acta Pharmacol Sin, 31(12):1583-92, 2010 13. Zhang XW, Cai WF, Hu ZW. Advances in the study of immunopathological mechanism of dilated cardiomyopathy. Advances in Cardiovascular Diseases, 30(5):814-817, 2009.