个人简介
教育背景:
2006.10-2008.10,美国密歇根州立大学,微生物与分子遗传学,访问学者/博士后,指导者:郑永辉
2000.9-2005.9,中国医学科学院医药生物技术研究所,微生物与生化药学,博士,导师:蒋建东
1989.9-1994.7,承德医学院,临床医学,学士
工作经历:
2014.9 - 至今,中国医学科学院,药物研究所,副研究员,硕士生导师
2008.10- 2014.8,中国医学科学院,医药生物技术研究所,副研究员,硕士生导师
1994.7- 2000.8,承德医学院,基础医学部,药理学讲师
研究领域
1. 抗感染新药研究,包括病毒/细菌致病机理研究、抗感染药物评价及作用机制研究;
2. 抗肿瘤新药研究,包括抗肿瘤药物新机制研究。
近期论文
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1. Fang Guo, Yanxing Han*, Xuesen Zhao, Jianghua Wang, Fei Liu, Chunxiao Xu, Lai Wei, Jian-Dong Jiang, Timothy M Block, Ju-Tao Guo, Jinhong Chang*. STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus. Antimicrob Agents Chemother. 2015 Feb;59(2):1273-81. (corresponding author, IF=4.451)
2. Junjun Cheng, Yanxing Han*, Jian-Dong Jiang*. Establishment of drug-resistant HBV small-animal models by hydrodynamic injection. Acta Pharmaceutica Sinica B. 2014,4(4):270-276. (corresponding author)
3. Li-Mei Gao†, Yan-Xing Han†, Yu-Ping Wang, Yu-Huan Li, Yong-Qiang Shan, Xin Li, Zong-Gen Peng, Chong-Wen Bi,Tian Zhang, Na-Na Du, Jian-Dong Jiang*, and Dan-Qing Song*. Design and Synthesis of Oxymatrine Analogues Overcoming Drug Resistance in Hepatitis B Virus through Targeting Host Heat Stress Cognate 70. J. Med. Chem., 2011, 54 (3), pp 869–876. (co-first author, SCI 5.207)
4. 天然多糖在体外抗甲型流感病毒作用的普遍性. 朱成杰, 赵昆,王桂芳,赵立勋,韩燕星*,蒋建东*. 中国抗生素杂志, 2010年12期, pp 919-923. (第一责任作者)
5. Zhen Yang, Yong-Xin Yu, Yan Qiu, Yan-Xing Han*, Jian-Dong Jiang. HCV positivity rate in the seronegative blood donors in China. Biomed Pharmacother. 2009 Feb 10. Biomed Pharmacother.2009 May;63(4):319-20.( corresponding author, SCI 2.208)
6. Tao Zhou*, Yanxing Han*, Ying Dang*, Xiaojun Wang, and Yong-Hui Zheng. A novel HIV-1 restriction acting biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR. Retrovirology.2009 Apr 3;6:31.(co-first author, SCI 5.236)
7. Yanxing Han*, Xiaojun Wang, Yin Dang, Yong-hui Zheng. APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication. PLoS Pathog. 2008 Jul 4;4(7):e1000095.(SCI 9.079)
8. Yanxing Han*, Xiaojun Wang, Yin Dang, Yong-hui Zheng. Demonstration of a novel HIV-1 restriction phenotype from a human T cell line. PLoS ONE. 2008 Jul 30;3(7):e2796. (SCI 4.411)
9. Han YX, Xue R, Zhao W, Zhou ZX, Li JN, Chen HS, Chen XH, Wang YL, Li YH, Wu YW, You XF, Zhao LX, Jiang JD. Antiviral therapeutic efficacy of foscarnet in hepatitis B virus infection. Antiviral Res. 2005 Dec;68(3):147-53. (SCI 4.439)