吴练秋 - 中国医学科学院药物研究所 -

个人简介

教育背景 1. 天津医科大学临床医学系本科毕业，获医学学士学位。 2. 中国协和医科大学病理学和病理生理学系硕士研究生毕业，获硕士学位。 3. 北京协和医学院免疫学系博士研究生毕业，获博士学位。工作经历 1. 1997年至2007年，任职于武警部队后勤学院临床医学系病理学与病理生理学教研室。 2. 2010年至今，任职于中国医学科学院药物研究所药理室。

研究领域

专业研究领域为抗炎免疫药物药理学，包括免疫和炎症相关疾病的新药研发和作用机制研究。

近期论文

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1. HaiJing Zhang, AnJun Deng, ZhiHui Zhang, ZiHan Yu, Yang Liu, ShanYing Peng, LianQiu Wu*, HaiLin Qin, WenJie Wang*. The Protective Effect of Epicatechin on Experimental Ulcerative Colitis in Mice Is Mediated by Increasing Antioxidation and by the Inhibition of NF-κB pathway. Pharmacological Reports, 2016. (online) 2. Haijing Zhang, Lianqiu Wu, Yang Liu, Shanying Peng, Wenjie Wang*. The antinociceptive effect and mechanism of action of SY0916. International Immunopharmacology, 2016. (online) 3. Zhang ZH, Zhang HJ, Deng A, Wang B, Li ZH, Liu Y, Wu LQ*, Wang WJ, Qin HL*.Synthesis and Structure-activity Relationships of Quaternary Coptisine Derivatives as Potential Anti-ulcerative Colitis Agents. J Med Chem. 2015; 58(18):7557-71 4. Hai-Jing Zhang, Wen-Yang Han, Shan-Ying Peng, Yang Liu, Lian-Qiu Wu*, & Wen-Jie Wang*. The inhibition effect and mechanism study of SY0916 on pulmonary fibrosis. Journal of Asian Natural Products Research. 2014; 16(6): 658–666 5. Wu LQ *, Zhang XM, Tang SQ, Che YC, Zhang Y, Liu LD, Li QH. A cellular response protein identified in HSV1 infection is capable of inhibitIng viral replication via interaction with ATF5. SCIENCE CHINA LIFE SCIENCES.2013; 56 (12): 1127–1133 6. Wu LQ*, OU Y, Liu Y, Wang L, Peng SHY, Wang WJ . Inhibitory effects of SY0916, a platelet activating factor receptor antagonist, on the angiogenesis of Human Umbilical Vascular endothelial cells. Journal of Asian Natural Products Research. 2011; 13(11):984-992 7. Zhi Hui Zhang, Lian Qiu Wu, An Jun Deng, Jin Qian Yu, Zhi Hong Li, Hai Jing Zhang, Wen Jie Wang, Hai Lin Qin*. New Synthetic Method of 8-Oxocoptisine Starting from Natural Quaternary Coptisine as anti-Ulcerative Colitis Agent. Journal of Asian Natural Products Research. 2014; 16(8) :841-846 8. Zhi-Hui Zhang, An-Jun Deng, Lian-Qiu Wu, Lian-Hua Fang, Jin-Qian Yu, Zhi-Hong Li, Tian-Yi Yuan, Wen-Jie Wang, Guan-Hua Du, Hai-Lin Qin*. Syntheses and structure–activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives. Eur. J. Med. Chem. 2014;86:542-549 9. JQ Yu, AnJ Deng, LQ Wu, ZH Zhang, Y Liu, WJ Wang, HL Qin*. Osteoclast-inhibiting Saikosaponin Derivertives from Bupleurum Chinense. Fitoterapia. 2013; 85: 101-108 10. Jin Ren, Yan-Gai Wang, Ai-Guo Wang, Lian-Qiu Wu, Hai-Jing Zhang, Wen-Jie Wang, Ya-Lun Su, Hai-Lin Qin*. Cembranoids from the Gum Resin of oswellia carterii as Potential Antiulcerative Colitis Agents. J Nat Prod. 2015;78:2322−2331 11. Jian Zhou , Chuang-Jun Li , Jing-Zhi Yang , Jie Ma, Lian-Qiu Wu, Wen-Jie Wang , Dong-Ming Zhang. Phenylpropanoid and lignan glycosides from the aerial parts of Lespedeza cuneata. Phytochemistry. 2016;121:58-64 12. Guo L, Wu WJ, Liu LD, Wang LC, ZhangY, Wu LQ , GuanY, Li QH*. Herpes Simplex Virus 1 ICP22 Inhibits the Transcription of Viral Gene Promoters by Binding to and Blocking the Recruitment of P-TEFb. PLOS ONE. 2012; 7 (9):e45749 13. 吴练秋，欧阳雪宇，刘洋，彭珊瑛，王霖，王文杰*。血小板激活因子受体拮抗剂SY0916抑制巨噬细胞血管生成作用的研究。中国药学杂志。2011；46(12)：46-52 14. 邓安珺，张海婧，张志辉，李志宏，马林，吴丰，吴练秋，王文杰，秦海林*。巨峰葡萄籽抗氧化活性成分研究。中国中药杂志。2015，40（21）：19-22 15. 刘洋，邓安郡，马林，张海婧，张志辉，吴练秋，申竹芳，王文杰*，秦海林*。小果博落回的化学成分及苯菲啶生物碱的xbp1转录激活作用评价。药学学报。2015;50（2）:207-210