个人简介
1990年-1994年于河南中医学院获中药学学士学位，1994年-1997年于河南中医学院获中药学硕士学位，1997年-2000年于北京中医药大学获博士学位，2006年-2007年于美国南阿拉巴马大学医学院药理系做博士后研究。2000年-至今于中国医学科学院药物研究所国家药物筛选中心工作，2012年9月-至今作为第七批援疆干部于新疆维吾尔自治区药物研究所药理二室工作，任副主任。
近期论文
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1. Guifen Qiang*, Li Zhang*, Xiuying Yang, Qi Xuan, Lili Shi, Hengai Zhang, Bainian Chen, Xiaoxiu Li, Mian Zu, Dan Zhou, Jing Guo, Haiguang Yang, Guanhua Du. Effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes. European Journal of Pharmacology, 2012, 685:156-164.
2. Xiaoyan Yu，Li Zhang，Xiuying Yang, Hua Huang, Zhonglin Huang, Lili Shi, Guanhua Du. Salvianolic Acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC 1 –Sirt3 axis. Molecular, 2012,17(9):11216-11228.
3. Li Zhang, Xinrui Cheng, Juanjuan Hu, Lan Sun, Guanhua Du. Neuroprotective effects of Hyperoside on sodium azide-induced apoptosis in PC12 Cells. Chinese Journal of Natural Medicine, 2011, 1-6.
4. Rui Liu, Li Zhang, Xi Lan, Li Li, Tiantai Zhang, Guanhua Du. Protection by borneol on cortical neurons against oxygen-glucose deprivation/reperfusion: involvement of anti-oxidation and anti-inflammation through nuclear transcription factor kappa B signaling pathway. Neuroscience, 2011, 176: 408–419.
5.Yi He, Li Zhang, Ming Zhao, Samhip Tsai, Yuying Zong, Chuntao Che. Phenolic compounds from Eurycorymbus cavaleriei. Journal of Asian Natural Products Research. 2011,13(6):575-580.
6. Li Zhang, Yongxian Cheng, Ailin Liu, Haidi Wang, Yaling Wang, Guanhua Du. Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa. Molecular, 2010, 15, 8507-8517.
7. Li Zhang, Juan-Juan Hu, Jian-Wei Lin, Wei-Shuo Fang, Guan-Hua Du. Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C. B. Clarke) Höeck. J of Ethnopharmacology 2009,123(3):510-4.
8. Li Zhang, Xinrui Cheng, Ruoyun Chen, Xiaoming Zhu, Lan Sun, Guanhua Du. Protective effect of composite of Chinese Medicine prescription Naodesheng against focal cerebral ischemia in Rat. Chin J Integr Med. 2009, 15(5):377-383.
9. Renqiang Mei, Yuehu Wang, Guanhua Du, Guangming Liu, Li Zhang*, Yongxian Cheng*. Antioxidant lignans from the fruits of Broussonetia papyrifera. Journal of Natural Products 2009, 72(4):621-625.
10. Bing Zhu, Li Zhang, Judy Creighton, Mikhail Alexeyev, Samuel J. Strada, Troy Stevens. Protein kinase A phosphorylation of Tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier. Am J Physiol Lung Cell Mol Physiol. 2010,299(4):L493-501.
11. Bing Zhu, Li Zhang, Mikhail Alexeyev, Diego F. Alvarez, Samuel J. Strada, Troy Stevens. Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype. Am J Physiol Lung Cell Mol Physiol, 2009,296(2):L220-228.
12. Li Zhang, Juanjuan Hu, Guanhua Du. Establishment of a cell-based assay to screen insulin-like hypoglycemic drugs. Drug Discovery & Therapeutics, 2008,2(4):229-233.
13. Junfeng Wang, Shasha Dong, Yuehu Wang, Qing LU, Huimin Zhong, Guanhua Du, Li Zhang*, Yongxian Cheng*. Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release. Bioorganic & Medicinal Chemistry. 2008, 16:8510-8515.
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