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个人简介

教育背景: 2001.9 - 2005.6 中国药科大学理科基地班学士 2005.9 – 2010.6 中国药科大学药物化学专业博士 工作经历: 2010.11-2013.6 中国医学科学院药物研究所合成药物化学研究室助理研究员 2013.7-至今 中国医学科学院药物研究所合成药物化学研究室副研究员

研究领域

基于成药性的药物分子设计,合成与生物活性研究; 基于生物活性的蛋白质功能研究及分子探针的设计与构建; 结构多样性芳杂环的有机方法学研究; 新药开发及合成工艺研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1 X. Wang*, C. Sun, L. Fang, D. Yin*, Discovery of novel sphingosine kinase 1 inhibitors via structure-based hierarchical virtual screening, MedChemComm, 6 (2015). 413-417 (IF=2.626) 2 Y. Tian, X. Wang*, Q. Xiao, C. Sun, D. Yin*, Synthesis of Dihydrobenzoheterocycles through Al(OTf)3-Mediated Cascade Cyclization and Ionic Hydrogenation, The Journal of Organic Chemistry, 79 (2014) 9678-9685. (IF=4.638) 3 J. Qi, C. Sun, Y. Tian, X. Wang*, G. Li, Q. Xiao, D. Yin*, Highly Efficient and Versatile Synthesis of Lactams and N-Heterocycles via Al(OTf)3-Catalyzed Cascade Cyclization and Ionic Hydrogenation Reactions, Organic Letters, 16 (2014) 190-192. (IF=6.324) 4 Y. Tian, J. Jin, X. Wang*, J. Hu, Q. Xiao, W. Zhou, X. Chen, D. Yin*, Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design, European Journal of Medicinal Chemistry, 85 (2014) 1-15. (IF=3.432) 5 Y. Tian, J. Qi, C. Sun, D. Yin, X. Wang*, Q. Xiao, One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization, Organic & Biomolecular Chemistry, 11 (2013) 7262-7266. (IF=3.487) 6 X. Wang, Y.-L. Tian, Q.-Y. Zhang, J.-G. Qi, D.-L. Yin*, An efficient synthesis of substituted 1,4-diazepines by a Pd catalyzed amination and sequential hydrogenation condensation, Chinese Chemical Letters, 24 (2013) 743-746. (IF=1.178) 7 X. Wang, J.-G. Qi, G. Li, Y.-L. Tian, D.-L. Yin*, An efficient method for preparing the sphingosine-1-phosphate receptor agonist, KRP203-phosphate, Chinese Chemical Letters, 24 (2013) 817-820. (IF=1.178) 8 X. Wang, M.Y. Xi, J.H. Fu, F.R. Zhang, G.F. Cheng, D.L. Yin, Q.D. You, Synthesis, biological evaluation and SAR studies of benzimidazole derivatives as H1-antihistamine agents, Chinese Chemical Letters, 23 (2012) 707-710. (IF=1.178) 9 X. Wang, N. Lu, Q. Yang, D. Gong, C. Lin, S. Zhang, M. Xi, Y. Gao, L. Wei, Q. Guo, Q. You, Studies on chemical modification and biology of a natural product, gambogic acid (III): determination of the essential pharmacophore for biological activity, European Journal of Medicinal Chemistry, 46 (2011) 1280-1290. (IF=3.432) 10 G. Li, Q. Xiao, C. Li, X. Wang*, D. Yin, A facile preparation of tetralins from arene-1,4-diones using titanium(IV)chloride and triethylsilane, Tetrahedron Letters, 52 (2011) 6827-6830. (IF=2.391) 11 Z.l. Liu, X. Wang, N.G. Li, H.P. Sun, J.X. Wang, Q.D. You, Total synthesis of aldehyde-containing Garcinia natural products isomorellin and gaudichaudione A, Tetrahedron, 67 (2011) 4774-4779. (IF=2.817) (共同第一作者) 12 X. Zhang, X. Li, H. Sun, X. Wang, L. Zhao, Y. Gao, X. Liu, S. Zhang, Y. Wang, Y. Yang, S. Zeng, Q. Guo, Q. You, Garcinia xanthones as orally active antitumor agents, Journal of Medicinal Chemistry, 56 (2013) 276-292. (IF=5.504) 13 Q.-Y. Zhang, X. Wang, Y.-L. Tian, J.-G. Qi, C. Li, D.-L. Yin*, One pot synthesis of dibenzodiazepinones via CuI catalysis in ethylene glycol, Chinese Chemical Letters, 24 (2013) 825-828. (IF=1.178) 14 Y. Tian, J. Jin, X. Wang, W. Han, G. Li, W. Zhou, Q. Xiao, J. Qi, X. Chen, D. Yin*, Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor, MedChemComm, 4 (2013) 1267-1274. (IF=2.626) 15 G. Zhang, X. Wang, C. Li, D. Yin*, Palladium-Catalyzed Cross-Coupling of Electron-Deficient Heteroaromatic Amines with Heteroaryl Halides, Synthetic Communications, 43 (2013) 456-463. (IF=0.984) 16 H. Sun, F. Chen, X. Wang, Z. Liu, Q. Yang, X. Zhang, J. Zhu, L. Qiang, Q. Guo, Q. You, Studies on gambogic acid (IV): Exploring structure–activity relationship with IκB kinase-beta (IKKβ), European Journal of Medicinal Chemistry, 51 (2012) 110-123. (IF=3.432) 17 G. Zhang, H. Zhang, X. Wang, C. Li, H. Huang, D. Yin, Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position, Molecules, 16 (2011) 6985-6991. (IF=2.095)

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