林生 - 中国医学科学院药物研究所 -

个人简介

教育背景 1997.9 -2001.7：北京中医药大学，本科。 2001.9 -2004.7：中国中医科学院，中药研究所，获医学硕士学位。 2004.9 -2007.7：中国医学科学院北京协和医学院，药物研究所，获理学博士学位。工作背景 2007.9-2009.7：上海解放军第二军医大学博士后流动站 2009.9-至今：中国医学科学院北京协和医学院药物研究所

研究领域

1. 中药药效物质的化学研究。 2. 中药内生真菌代谢产物的研究。

近期论文

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1. Sheng Lin, Ji Ye, Xu Liang, Xi Zhang, Juan Su, Peng Fu, Di-Ya Lv, Lei Shan, Yun-Heng Shen, Hui-Liang Li, Xian-Wen Yang, and Wei-Dong Zhang*. Mass spectrometric profiling of valepotriates possessing various acyloxy groups from Valeriana jatamansi. J. Mass Spectrom. 2015, 50: 1294-1304. 2. Sheng Lin, Peng Fu, Tao Chen, Ji Ye, Yong-Qing Su, Xian-Wen Yang, Zhong-Xiao Zhang, and Wei-Dong Zhang*. Minor valepotriates from Valeriana jatamansi and their cytotoxicity against metastatic prostate cancer cells. Planta Med., 2015, 81: 51-61. 3. Sheng Lin, Ke-Yv Chen, Peng Fu, Ji Ye, Yong-Qing Su, Xian-Wen Yang, Zhong-Xiao Zhang, Lei Shan, Hui-Liang Li, Yun-Heng Shen, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang*. Structure determination of two unusual C25 steroids with bicyclo[4.4.1]A/B rings from Penicillium decumbens by NMR spectroscopy. Magn. Reson. Chem., 2015, 53: 223-226. 4. Sheng Lin, Tao Chen, Peng Fu, Ji Ye, Xian-Wen Yang, Lei Shan, Hui-Liang Li, Yun-Heng Shen, Run-Hui Liu, Xi-Ke Xu, and Wei-Dong Zhang*. Three decomposition products of valepotriates from Valeriana jatamansi and their cytotoxic activity. J. Asian Nat. Prod. Res., 2015, 17: 455-461. 5. Sheng Lin, Zhong-Xiao Zhang, Tao Chen, Ji Ye, Wei-Xing Dai, Lei Shan, Juan Su, Yun-Heng Shen, Hui-Liang Li, Run-Hui Liu, Xi-Ke Xu, Hui Wang*, and Wei-Dong Zhang*. Characterization of chlorinated valepotriates from Valeriana jatamansi. Phytochemistry, 2013, 85: 185-193. 6. Fang Wang, Yue-Ping Jiang, Xiao-Liang Wang, Su-Juan Wang, Peng-Bin Pu, Sheng Lin*, Cheng-Gen Zhu, and Jian-Gong Shi*. Aromatic glycosides from the flower buds of Lonicera japonica. J. Asian. Nat. Prod. Res. 2013, 15: 492-501. 7. Peng-Bin Pu, Yan-Ru Li, Ming Jiang, Fang Wang, Xiao-Liang Wang, Sheng Lin*, Cheng-Gen Zhu, and Jian-Gong Shi*. Glycosides from the Bark of Machilus robusta. J. Asian. Nat. Prod. Res. 2013, 15: 482-491. 8. Ming-Tao Liu, Sheng Lin*, Mao-Luo Gan, Ming-Hua Chen, Li Li, Su-Juan Wang, Jia-Chen Zi, Xiao-Na Fan, Ying Liu, Yi-Kang Si, Yong-Chun Yang, Xiao-Guang Chen, and Jian-Gong Shi*. Yaoshanenolides A and B: new spirolactones from the bark of Machilus yaoshansis. Org. Letters, 2012, 4:1004-1007. 9. Mao-Luo Gan, Ming-Tao Liu, Li-She Gan, Sheng Lin*, Bo Liu, Yan-Ling Zhang, Jia-Chen Zi, Wei-Xia Song, Jian-Gong Shi*. Dammarane glycosides from the Root of Machilus yaoshansis. J. Nat. Prod. 2012, 75: 1373-1382. 10. Sheng Lin, Yan-Ling Zhang, Ming-Tao Liu, Jia-Chen Zi, Mao-Luo Gan, Wei-Xia Song, Xiao-Na Fan, Su-Juan Wang*, Yong-Chun Yang, and Jian-Gong Shi*. Methoxylated fatty acids from the bark of Fraxinus sieboldiana. J. Asian. Nat. Prod. Res. 2012, 14:235-243. 11. Ming-Tao Liu, Sheng Lin*, Mao-Luo Gan, Bo Liu, Jia-Chen Zi, Wei-Xia Song, Yang-Ling Zhang, Xiao-Na Fan, Ying Liu, Wei Tan, Su-Juan Wang, Yong-Chun Yang, and Jian-Gong Shi*. Butanolide derivatives bark of Machilus yaoshansis. J. Asian. Nat. Prod. Res. 2012, 14:713-720. 12. Sheng Lin, Ting Shi, Ke-Yv Chen, Zhong-Xiao Zhang, Lei Shan, Yun-Heng Shen, and Wei-Dong Zhang. Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens. Chem. Commun., 2011, 47, 10413-10415. 13. Mao-Luo Gan, Ming-Tao Liu, Bo Liu, Sheng Lin*, Yan-Ling Zhang, Jia-Chen Zi, Wei-Xia Song, Fei Ye, Xiao-Guang Chen and Jian-Gong Shi*. Cucurbitane glucosides from the root of Machilus yaoshansis, J. Nat. Prod. 2011, 74: 2431-2437. 14. Sheng Lin, Yangling Zhang, Mingtao Liu, Sen Yang, Maoluo Gan, Jiachen Zi, Weixia Song, Xiaona Fan, Sujuan Wang, Yang Liu, Yongchun Yang, Xiaoguang Chen, Ying Guo, Wenjie Wang and Jiangong Shi*. Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities. J. Nat. Prod. 2010, 73: 1914-1921. 15. Sheng Lin, Yun-Heng Shen, Zhong-Xiao Zhang, Hui-Liang Li, Lei Shan, Run-Hui Liu, Xi-Ke Xu, and Wei-Dong Zhang*. Revision of the structures of 1,5-dihydroxy-3,8-epoxyvalechlorine, volvaltrate B, and valeriotetrate C from Valeriana jatamansi and V. officinalis. J. Nat. Prod. 2010, 73: 1723-1726. 16. Sheng Lin, Tao Chen, Xiao-Hua Liu, Yun-Heng Shen, Hui-Liang Li, Lei Shan, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang* and Hui Wang*. Iridoids and lignans from Valeriana jatamansi. J. Nat. Prod. 2010, 73: 632-638. 17. Sheng Lin, Yun-Heng Shen, Hui-Liang Li, Xian-Wen Yang, Tao-Chen, Long-Hai Lu, Zheng-Sheng Huang, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang* and Hui Wang*. Acylated iridoids with cytotoxicity from Valeriana jatamansi. J. Nat. Prod. 2009, 72: 650-655. 18. Sheng Lin, Sujuan Wang, Mingtao Liu, Maoluo Gan, Shuai Li, Yongchun Yang, Yinghong Wang, Wenyi He and Jiangong Shi*. Glycosides from the bark of Fraxinus sielboldiana. J. Nat. Prod. 2007, 70: 817-823. 19. Sheng Lin, Yang-Lin Zhang, Ming-Tao Liu, Jia-Chen Zi, Mao-Luo Gan, Wei-Xia Song, Xiao-Na Fan, Su-Juan Wang, Yong-Chun Yang, and Jian-Gong Shi*. Two new ar-bisabol sesquiterpenes from the stem bark of Fraxinus sielboldiana. Acta Pharmaceutica Sinica B, 2011, 1: 89-92. 20. 林生，张艳玲，刘明韬，訾佳辰，甘茂罗，宋卫霞，樊晓娜，王素娟，杨永春，石建功*. 小蜡树化学成分的研究. 中国中药杂志, 2015, 40(13): 2602-2611.