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个人简介

教育背景 2004/12- 2007/10,香港中文大学,中医药学院,博士 1997/09- 2000/06,中国医学科学院药物研究所,药物分析专业,理学硕士 1988/08- 1992/07,上海第二军医大学,药学专业,理学学士 工作经历 2012/05-至今,中国医学科学院药物研究所药物代谢室,课题组长, 先后任副研究员,硕士生导师,研究员,博士生导师; 2007/12-2012/04,中国医学科学院药物研究所分析室,课题组长,副研究员,硕士生导师; 2003/09-2004/12,先后两次赴美国康涅狄格老化与癌症研究所,访问学者; 2001/09-2003/06,中国医学科学院药物研究所新药开发二室,课题组长; 1995/10-2001/09,中国医学科学院药物研究所分析室,先后为实习研究员、助理研究员; 1992/09-1995/10,国防科工委(现总装备部)后勤部药检所,实习研究员。

研究领域

1. 肠道菌作用下药物的代谢转化及分子基础; 2. 我国原创的天然药物及天然活性成分的代谢转化及药代动力学的研究; 3. 用于结直肠癌早期诊断的多肽探针体内代谢特征评价及关键技术研究; 4. 基于手性拆分新技术和新方法,开展天然手性药物的药代研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Xiao‑Yang Li, Zhen‑Xiong Zhao, Min Huang, Ru Feng, Chi‑Yu He, Chao Ma, Shi‑Heng Luo, Jie Fu, Bao‑Ying Wen, Long Ren, Jia‑Wen Shou, Fang Guo, Yangchao Chen, Xin Gao, Yan Wang*, Jian‑Dong Jiang*. Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters. Journal of Translational Medicine, 2015, 13(1): 278. 2. Hong-Mei Yan , Ming-Feng Xia, Yan Wang, Xin-Xia Chang, Xiu-Zhong Yao, Sheng-Xiang Rao, Meng-Su Zeng, Yin-Fang Tu, Ru Feng, Wei-Ping Jia, Jun Liu, Wei Deng, Jian-Dong Jiang*, Xin Gao*. Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. PLoS One, 2015, 10 (8): e0134172. DOI: 10.1371/journal.pone. 0134172. 3. Ru Feng, Jia-Wen Shou, Zhen-Xiong Zhao, Chi-Yu He, Chao Ma, Min Huang, Jie Fu, Xiang-Shan Tan, Xiao-Yang Li, Bao-Ying Wen, Xi Chen, Xin-Yi Yang, Gang Ren, Yuan Lin, Yangchao Chen, Xue-Fu You, Yan Wang*, Jian-Dong Jiang*. Transforming berberine into its intestine absorbable form by gut microbiota. Scientific Reports, 2015, 5: 12155. 4. Yan Wang*, Jia-Wen Shou, Jian-Dong Jiang*. Metabolism of Chinese Materia Medica in gut microbiota and biological effects. Chinese Herbal Medicines, 2015, 7(2): 109-115. 5. Bao-Hui Cheng, Xuelin Zhou, Yan Wang, Judy Yuet-Wa Chan, Huang-Quan Lina, Penelope M.Y. Or, David Chi-Cheong Wan, Ping-Chung Leung, Kwok-Pui Funga, Yi-Fen Wang*, Clara Bik-San Laua*. Herb-drug interaction between an anti-HIV Chinese herbal SH formula and Atazanavir in vitro and in vivo. Journal of Ethnopharmacology, 2015, 162(13): 369-376. 6. Zhangang Xiao, Chi Han Li, Stephen L. Chan, Feiyue Xu, Lu Feng, Yan Wang, Jian-Dong Jiang, Joseph JY Sung, Christopher HK Cheng, and Yangchao Chen*. A small-molecule modulator of the tumor-suppressor mir34a inhibits the growth of hepatocellular carcinoma. Cancer Research, 2014, 74(21): 6236-6247. 7. Chi-Yu He, Jie Fu, Jing-Yi Ma, Ru Feng, Xiang-Shan Tan, Min Huang, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Xian-Feng Zhang*, Yangchao Chen* and Yan Wang*. Biotransformation and in vitro metabolic profile of bioactive extracts from a traditional miao-nationality herbal medicine, Polygonum capitatum. Molecules, 2014, 19: 10291-10308. 8. Jing-Yi Ma, Xuelin Zhou, Jie Fu, Tao Hu, Penelope M.Y. Or, Ru Feng, Chi-Yu He, Wen-Jing Chen, Xian-Feng Zhang*, Yangchao Chen**, Yan Wang***, John H.K. Yeung. Metabolite profiling analysis of FR429, an ellagitannin purified from Polygonum capitatum, in rat and human liver microsomes, cytosol and rat primary hepatocytes in vitro. Chemico-Biological Interactions, 2014, 220: 33-40. 9. Ming Zhao*, Xianming Zhang, Yan Wang*, Min Huang, Jin-Ao Duan, Tanja Gödecke, Karina M. Szymulanska-Ramamurthy, Zhiqi Yin, Chun-Tao Che. Germacranes and m-Menthane from Illicium lanceolatum. Molecules, 2014, 19(4): 4326-4337. 10. Ru Feng, Xuelin Zhou, Xiang-Shan Tan, Penelope M.Y. Or, Tao Hu, Jie Fu, Jing-Yi Ma, Min Huang, Chi-Yu He, Jian-Gong Shi, Chun-Tao Che, John H.K. Yeung*, Yan Wang*. In vitro identification of cytochrome P450 isoforms responsible for the metabolism of 1-hydroxyl-2, 3, 5-trimethoxy-xanthone purified from Halenia elliptica D. Don. Chemico-Biological Interactions, 2014, 210: 12-19. 11. Yan Wang, Jing-Yi Ma, SC Chow, Chi-Han Li, Zhangang Xiao, Ru Feng, Jie Fu, Yangchao Chen*. A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2. Tumor Biology, 2014, 35 (1): 205-212. 12. Xiang-Shan Tan, Jing-Yi Ma, Ru Feng, Chao Ma, Wen-Jing Chen, Yu-Peng Sun, Jie Fu, Min Huang, Chi-Yu He, Jia-Wen Shou, Wen-Yi He, Yan Wang*, Jian-Dong Jiang*. Tissue distribution of Berberine and its metabolites after oral administration in rats. PLoS One, 2013, 8(10): e77969. doi:10.1371/journal.pone.0077969. 13. Jing-Yi Ma, Ru Feng, Xiang-Shan Tan, Chao Ma, Jia-Wen Shou, Jie Fu, Min Huang, Chi-Yu He, Shuo-Nan Chen, Zhen-Xiong Zhao, Wen-Yi He, Yan Wang*, Jian-Dong Jiang**. Excretion of berberine and its metabolites in oral administration in rats. Journal of Pharmaceutical Sciences, 2013, 102(11): 4181-4192. 14. Ming-Na Sun, Jin-Feng Hu, Xiu-Yun Song, Dong-Hui Wu, Ling-Lei Kong, Yu-Peng Sun, Dong-Mei Wang, Yan Wang**, Nai-Hong Chen***, Gang Liu*. Coumarin derivatives protect against ischemic brain injury in rats. European Journal of Medicinal Chemistry, 2013, 67: 39-53. 15. Min Huang, Wen-Jing Chen, Ying Zhou, Ru Feng, Jie Fu, Jing-Yi Ma, Xiang-Shan Tan, Chi-Yu He ,Qi-Ming Zhang, Wen-Yi He, Yu-Lin Deng, Yu-Kui Zhang, Xian-Feng Zhang, Yan Wang*. Enantiomeric separations of four basic drugs containing N-alkyl groups by a RP-HPLC system using SBE-β-CD as chiral mobile phase additive. Chinese Chemical Letters, 2013, 24 (9): 840-844. 16. Yan Wang**, Ying Zhou, Chao Ma, Bei-Bei Yang, Ru Feng, Yi-Ying Zhang, Jie Fu, Wen-Jing Chen, Yu-Peng Sun, Jing-Yi Ma, Qi-Ming Zhang, Yu-Lin Deng, Yu-Kui Zhang, Wen-Yi He. High performance liquid chromatographic separation of eight drugs collected in Chinese Pharmacopoeia 2010 on amylose ramification chiral stationary phase. Acta Pharmaceutica Sinica B, 2012, 2 (5): 527-533. 17. Jie Fu, Jing-Yi Ma, Xian-Feng Zhang, Yan Wang**, Ru Feng, Yang-Chao Chen, Xiang-Shan Tan, Yi-Ying Zhang, Yu-Peng Sun, Ying Zhou, Chao Ma, Chi-Yu He, Zhen-Xiong Zhao, Xiao-Wei Du. Identification of metabolites of FR429, a potential antitumor ellagitannin, transformed by rat intestinal bacteria in vitro, based on liquid chromatography–ion trap-time of flight mass spectrometry analysis. Journal of Pharmaceutical and Biomedical Analysis, 2012, 71: 162-167. 18. Ru Feng, Xuelin Zhou, Penelope M.Y. Or, Jing-Yi Ma, Xiang-Shan Tan, Jie Fu, Chao Ma , Jian-Gong Shi, Chun-Tao Che, Yan Wang**, John H.K. Yeung*. Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2, 3, 5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes. Phytomedicine, 2012, 19: 1125-1133. 19. Ru Feng, Yi-Ying Zhang, Xi Chen, Yan Wang**, Jian-Gong Shi, Chun-Tao Che, John H.K. Yeung, Jing-Yi Ma, Xiang-Shan Tan, Chen Yang, Yu-Lin Deng, Yu-Kui Zhang. In vitro study on metabolite profiles of bioactive xanthones isolated from Halenia elliptica D. Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2012, 62: 228–234. 20. Ying Zhou, Chao Ma, Yan Wang**, Qi-Ming Zhang, Yi-Ying Zhang, Jie Fu, Hong Gao, Li-Xun Zhao. High performance liquid chromatographic separation of thirteen drugs collected in Chinese Pharmacopoeia 2010 (Ch.P2010) on cellulose ramification chiral stationary phase. Journal of Pharmaceutical Analysis, 2012, 2: 48-55.

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