张金兰 - 中国医学科学院药物研究所 -

个人简介

学习经历 1992年7月毕业于北京大学医学部药学院，获理学学士学位； 1995年7月毕业于中国医学科学院药物研究所，获理学硕士学位。 1999年9月至2002年7月在中国医学科学院药物研究所攻读博士学位，获药物分析学博士学位。工作简历 1999年9月至2002年7月在中国医学科学院药物研究所分析室工作，任助研和副研究员。 2002年8月至2004年5月：在北京大学医学部药学院进行博士后研究工作。 2004年6月作为分析学科引进人才在中国医学科学院药物研究所分析室，国家药物及代谢产物分析研究中心工作，任副研究员和研究员。

研究领域

1. 中草药有效成分成分含量测定方法的建立及标准制定 2. 常用中草药主要有效成分及复杂体系的代谢研究 3. 脂质组学分析技术研究及基于脂质组学与疾病相关生物标志物的研究 4. 新药药代和毒代动力学的研究 5. 新技术和新方法在药物研发方面的研究和应用

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Tie, C.*, Hu, T, Jia, Z. X., Zhang, J. L.** , Automatic Identification Approach for High-Performance Liquid Chromatography-Multiple Reaction Monitoring Fatty Acid Global Profiling. Analytical chemistry , 2015, 87, 8181-8185. 2. Liang Qu, Yao Xiao, Zhixin Jia, Zhe Wang, Caihong Wang, Ting Hu, Caisheng Wu, Comprehensive two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry for chemical constituents analysis of tripterygium glycosides tablets, Jinlan Zhang*. Journal of Chromatography A, 2015,38,1400, 65–73. 3. Cai, T.*, Ting, H., Jin-Lan, Z**. Novel identification strategy for ground coffee adulteration based on UPLC-HRMS oligosaccharide profiling. Food chemistry 2016, 190, 1046-1049. 4. Caihong Wang, Caisheng Wu, Jinlan Zhang*, Ying Jin. Systematic considerations for a multicomponent pharmacokinetic study of Epimedii wushanensis herba: From method establishment to pharmacokinetic marker selection. Phytomedicine, 2015, 22, 487-97. 5. Tie, C.*, Hu, T., Guo, B., & Zhang, J**. Novel strategy for herbal species classification based on UPLC-HRMS oligosaccharide profiling. J Pharm Biomed Anal, 2015, 111, 14-20. 6. Zhe Wang, Caisheng Wu, Gangli Wang, Qingsheng Zhang, Jinlan Zhang*. Novel strategy for the determination of illegal adulterants in health foods and herbal medicines using high-performance liquid chromatography with high-resolution mass spectrometry. Journal of Separation Science, 2015, 38, 925–935. 7. Liang Qu, Feng Qu, Zhixin Jia, Caihong Wang, Caisheng Wu, Jinlan Zhang*. Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide, Journal of Ethnopharmacology, 170 (2015) 28–38. 8. Cai Tie, Ting Hu, Xinxiang Zhang, Jiang Zhou, Jinlan Zhang. HPLC-MRM Relative Quantification analysis of Fatty Acids Based on a Novel Derivatization Strategy. Analyst, 2014; 139, 6154-6159. 9. Qiang Ren, Yingfei Li, Caisheng Wu, Caihong Wang, Ying Jin, Jinlan Zhang. Metabolism secondary metabolites isolatd from Tartary buckwheat and its extract. Food Chemistry, 2014; 154, 134-144. 10. Feng Qu, Sujun Zheng, Caisheng Wu, Zhixin Jia, Jinlan Zhang, Zhongping Duan. Lipidomic profiling of plasma in patients with chronic hepatitis C infection. Analytical and bioanalytical chemistry, 2014; 406, 555-564. 11. Jinfeng Hou, Qian Liu, Yingfei Li, Hua Sun, Jinlan Zhang. An in vivo microdialysis study of FLZ Penetration through the Blood-Brain Barrier in Normal and 6-Hydroxydopamine Induced Parkinson’s Disease Model Rats. BioMed Research international, 2014; 2014, 850493. 12. Qian Liu, Jinfeng Hou, Xiaoguang Chen, Gengtao Liu, Dan Zhang, Hua Sun, Jinlan Zhang. P-Glycoprotein Mediated Efflux Limits the transport of the Novel Anti-Parkinson’s Disease Candidate Drug FLZ across the Physiological and PD Pathological in vitro BBB Models. PLOS ONE, 2014; 9, e102442. 13. Zhixin Jia, Caisheng Wu, Hongtao Jin, Jinlan Zhang. Identification of the chemical components of Saussurea involucrate by high-resolution mass spectrometry and the mass spectral trees similarity filter technique. Rapid communications in mass spectrometry, 2014; 28, 2237-2251. 14. Feng Qu, Sujun Zheng, Shuang Liu, Caisheng Wu, Zhongping Duan, Jinlan Zhang. Serum Sphingolipids reflect the Severity of Chronic HBV Infection and Predict the Mortality of HBV-Acute-on-Chronic Liver Failure. PLOS ONE, 2014; 9, e104988. 15. Ying Jin, Cai-Sheng Wu, Jin-Lan Zhang, Ying-Fei Li，A new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometry，Analytica Chimica Acta, 768 (2013) :111– 117 16. Qiang Ren, Caisheng Wu, Jinlan Zhang, Use of on-line stop-flow heart-cutting two-dimensional high performance liquid chromatography for simultaneous determination of 12 major constituents in tartary buckwheat (Fagopyrum tataricum Gaertn) , Journal of Chromatography A, 1304 (2013) :257– 262 17. Feng Qu, Cai-Sheng Wu, Jin-Feng Hou, Ying Jin, Jin-Lan Zhang，Sphingolipids as New Biomarkers for Assessment of Delayed-Type Hypersensitivity and Response to Triptolide，PLOS one, 7（2012）：1-12 18. Qiang Ren, Caisheng Wu, Yan Ren, Jinlan Zhang，Characterization and identification of the chemical constituents from tartary buckwheat (Fagopyrum tataricum Gaertn) by high performance liquid chromatography/photodiode array detector/linear ion trap FTICR hybrid mass spectrometry，Food Chemistry, 136 (2013) :1377–1389 19. Jinfeng Hou, Feng Qu, Caisheng Wu, Qiang Ren, Jinlan Zhang,Quantitative determination and pharmacokinetic study of the novel anti-Parkinson’s disease candidate drug FLZ in rat brain by high performance liquid chromatography–tandem mass spectrometry，Journal of Pharmaceutical and Biomedical Analysis, 66 (2012): 232– 239. 20. Yan Ren， Caisheng Wu，Jinlan Zhang，Simultaneous screening and determination of 18 illegal adulterants in herbal medicines and health foods for male sexual potency by ultra-fast liquid chromatographyelectrospray ionization tandem mass spectrometry，J. Sep. Sci., 35（2012）: 2847–2857

学术兼职

《中国药学》（英文版）第三、四届编委，《药物分析杂志》第七、八届编委，中国质谱学会有机专业委员会副主任委员，全国生物计量技术委员会委员，中国毒理学会毒物分析专业委员会委员，中国药学会药物检测质量管理专业委员会，中国分析测试协会青年学术委员会，中华中医药学会中药资源分会委员，国家食品药品监督管理总局化妆品标准委员会委员，国家食品药品监督管理总局化妆品安全标准委员会委员，卫生部化妆品标准委员会委员，中国实验室合格评定委员会（CNAS）实验室认可评审员，国际反兴奋剂组织（WADA）实验室认可评审员。