再帕尔·阿不力孜 - 中国医学科学院药物研究所 -

个人简介

教育背景 1979.09－1983.07 新疆大学化学系分析化学专业学士学位 1985.09－1988.03 日本明星大学化学系物理有机化学专业硕士研究生，理学硕士 1991.04－1993.05 日本东邦大学理学院化学系招聘研究员，并获得理学博士工作经历 1983.08－1985.09 新疆大学化学系助教 1988.04－1991.04 新疆大学化学系助教、讲师、副教授 1993.05－1994.07 日本东邦大学药学院客座研究员 1994.10－1996.11 中国医学科学院药物研究所博士后 1996.12—至今博士后出站后作为引进人才，在药物研究所工作至今。1997年2月被聘为研究员， 2000年被评为博士生导师，1998年至今担任所学术委员会委员 2001.10－2002.03 日本科学技术振兴事业团及日本千叶大学分析中心客座研究员 2002年起先后担任药物研究所仪器分析中心主任、“国家药物及代谢产物分析研究中心”副主任、主任 2004.06－2009.05 中国医学科学院/北京协和医学院院校长助理 2009.05－2013.04 院校科技管理处处长 2013.04－2014.09 研究生院常务副院长 2011年起兼任天然药物活性物质与功能国家重点实验室副主任、中国医学科学院药物研究院副院长；2013年当选院校第六届学术委员会执委会委员。 2014.09起担任中央民族大学副校长。

研究领域

1) 天然药物活性物质多组分复杂体系的质谱分析方法研究; 2) 药物体内外分析以及药物代谢组学的分析方法研究； 3) 恶性肿瘤等重大疾病的代谢组学分析方法研究及其小分子标志物的发现; 4) 质谱离子化及其质谱分子成像新技术的研制与应用研究。

近期论文

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Xiaowei Song, Zhigang Luo, Xin Li, Tiegang Li, Zhonghua Wang, Chenglong Sun, Luojiao Huang, Ping Xie, Xiaoyu Liu, Jiuming He*, Zeper Abliz*. In situ Hydrogel Conditioning of Tissue Samples to Enhance the Drug’s Sensitivity in Ambient Mass Spectrometry Imaging. Anal Chem, 2017, 89(12): 6318-6323. Yanhua Chen†, Zhi Zhou†, Wei Yang, Nan Bi, Jing Xu, Jiuming He, Ruiping Zhang, Lvhua Wang, Zeper Abliz*. Development of a Data-Independent Targeted Metabolomics Method for Relative Quantification Using Liquid Chromatography Coupled with Tandem Mass Spectrometry. Anal Chem, 2017, 89(13): 6954-6962. Zhi Zhou, Yanhua Chen*, Jiuming He, Jing Xu, Ruiping Zhang, Yan Mao, Zeper Abliz. Systematic evaluation of serum and plasma collection on the endogenous metabolome. Bioanalysis, 2017, 9(3): 239-250. Rui Zhang†, Peishan Hu†, Qingce Zang, Xiaofei Yue, Zhi Zhou, Xiaoyu Xu, Jing Xu, Shanshan Li, Yanhua Chen, Boqin Qiang, Xiaozhong Peng, Wei Han*, Ruiping Zhang*, Zeper Abliz. LC-MS-based metabolomics reveals metabolic signatures related to glioma stem-like cell selfrenewal and differentiation. RSC Adv, 2017, 7(39): 24221-24232. Qingce Zang, Yang Gao, Luojiao Huang, Jiuming He, Sheng Lin, Hongtao Jin, Ruiping Zhang, Zeper Abliz*. Rapid and sensitive liquid chromatography–tandem mass spectrometric method for the quantitative determination of potentially harmful substance 5, 5’-oxydimethylenebis (2-4 furfural) in traditional Chinese medicine injections. Acta Pharmaceutica Sinica B, 2018, 8(2): 235-241. Jiuming He†, Luojiao Huang†, Runtao Tian, Tiegang Li, Chenglong Sun, Xiaowei Song, Yiwei Lv, Zhigang Luo, Xin Li, Zeper Abliz*. MassImager: A software for interactive and in-depth analysis of mass spectrometry imaging data. Anal Chim Acta, 2018, 1015: 50-57. Chenglong Sun, Jiuming He, HongboWu, Xiaowei Song, Jiangshuo Li, Luojiao Huang, Xiaoyu Xu, Manjiangcuo Wang, Ruiping Zhang, Zeper Abliz*. A rapid and sensitive UPLC–MS/MS method for quantitative determination of arformoterol in rat plasma, lung and trachea tissues. Chin Chem Lett, 2018, https://doi.org/10.1016/j.cclet.2018.01.015. Zhigang Luo, Jingjing He, Jiuming He, Lan Huang, Xiaowei Song, Xin Li, Zeper Abliz*. Quantitative analysis of drug distribution by ambient mass spectrometry imaging method with signal extinction normalization strategy and inkjet-printing technology. Talanta, 2018, 179: 230-237. Xinxin Mao†, Jiuming He†, Tiegang Li, Zhaohui Lu, Jian Sun, Yunxiao Meng, Zeper Abliz*, Jie Chen*. Application of imaging mass spectrometry for the molecular diagnosis of human breast tumors. Sci Rep, 2016, 6: 21043. Yanhua Chen†, Jing Xu†, Ruiping Zhang, Zeper Abliz*. Methods used to increase the comprehensive coverage of urinary and plasma metabolomes by MS. Bioanalysis, 2016, 8(9): 981-997. Huiqing Wang, Jing Xu, Yanhua Chen, Ruiping Zhang, Jiuming He, Zhonghua Wang, Qingce Zang, Jinfeng Wei, Xiaowei Song, Zeper Abliz*. Optimization and Evaluation Strategy of Esophageal Tissue Preparation Protocols for Metabolomics by LC–MS. Anal Chem, 2016, 88(7): 3459-3464. Jing Xu, Yanhua Chen, Ruiping Zhang, Jiuming He, Yongmei Song, Jingbo Wang, Huiqing Wang, Luhua Wang, Qimin Zhan, Zeper Abliz*. Global metabolomics reveals potential urinary biomarkers of esophageal squamous cell carcinoma for diagnosis and staging. Sci Rep, 2016, 6: 35010. Yan Gao, Ruiping Zhang, Jinfa Bai, Xuejun Xia, Yanhua Chen, Zhigang Luo, Jing Xu, Yang Gao, Yuling Liu, Jiuming He*, Zeper Abliz*. Targeted Data-Independent Acquisition and Mining Strategy for Trace Drug Metabolite Identification Using Liquid Chromatography Coupled with Tandem Mass Spectrometry. Anal Chem, 2015, 87(15): 7535-7539. Jingjing He†, Zhigang Luo†, Lan Huang, Jiuming He, Yi Chen, Xianfang Rong, Shaobo Jia, Fei Tang, Xiaohao Wang, Ruiping Zhang, Jianjun Zhang, Jiangong Shi*, Zeper Abliz*. Ambient Mass Spectrometry Imaging Metabolomics Method Provides Novel Insights into the Action Mechanism of Drug Candidates. Anal Chem, 2015, 87(10): 5372-5379. Tiegang Li†, Jiuming He†, Xinxin Mao, Ying Bi, Zhigang Luo, Chengan Guo, Fei Tang, Xin Xu, Xiaohao Wang, Mingrong Wang, Jie Chen*, Zeper Abliz*. In situ biomarker discovery and label-free molecular histopathological diagnosis of lung cancer by ambient mass spectrometry imaging. Sci Rep, 2015, 5: 14089. Zhonghua Wang, Yajie Zheng, Baoxin Zhao, Yanping Zhang, Zhe Liu, Jing Xu, Yanhua Chen, Zhao Yang, Fenfen Wang, Huiqing Wang, Jiuming He, Ruiping Zhang*, Zeper Abliz*. Human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach. J Proteome Res, 2015, 14(6): 2583-2593. Qingce Zang, Yang Liu, Jiuming He, Xiaofei Yue, Ruiping Zhang, Renzhi Wang, Zeper Abliz*. A sensitive and rapid HPLC–MS/MS method for the quantitative determination of trace amount of bromocriptine in small clinical prolactinoma tissue. Journal of Chromatography B, 2015, 989: 91-97.