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个人简介

2006年毕业于中国医学科学院药物研究所药理学专业获得博士学位,2006-2011年在美国加州大学圣迭戈分校医学院完成博士后研究,随后在美国加州大学圣迭戈分校医学院工作4年,历任项目科学家、助理教授。2015年回国后在中国医学科学院药物研究所建立糖尿病药理实验室,现为中国医学科学院&北京协和医学院药物研究所研究员、博士生导师

研究领域

目前课题组隶属于“天然药物活性物质与功能”国家重点实验室,主要研究领域包括内分泌学和内分泌药理学、免疫生物学和免疫药理、分子细胞生物学和药理学、信号传导通道调节机制等。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Li P*, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A,Chung H, Mayoral R, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM*. LTB4promotes insulin resistance in obese mice by acting on macrophages, hepatocytesand myocytes. Nat Med. 2015; 21(3): 239-47. (* co-corresponding author) PMID: 25706874 2. Li, P. *, Spann, N.*, Kaikkonen, M., Lu, M., Oh, D., Fox, J., Bandyopadhyay, G., Talukdar, S., Xu, J., Lagakos, W., Patsouris, D., Armando, A., Quehenberger, O., Dennis, E., Watkins, S., Auwerx, J., Glass, C., Olefsky, J. NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids. Cell 2013; 155, 200-214. (* co-first author) PMID: 24074869 3. Baeza-Raja B, Li PP*, D. Sachs B, Davalos D, Eirini Vagena, Schachtrup C, Loucks FA, Sikorski S, Helmrick M, Le Moan N, Bridges D, Tsigelny I, Baron LJ, Wynshaw-Boris. Anthony , Miriam Scadeng, Saltiel AR, Olefsky JM, Akassoglou K: p75 Neurotrophin Receptor Promotes Obesity and the Metabolic Syndrome. Proc Natl Acad Sci U S A 2012; 109(15):5838-43 (* co-first author) PMID: 22460790 4. Li PP, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM: Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 2011;147:815-826. PMID: 22078880 5. Lee YS, Li PP*, Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB: Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 2011;60:2474-2483. (* co-first author). PMID: 21911747 6. Li PP, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM: Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem 2010;285:15333-15345. PMID: 20308074 7. Lu M, Li PP*, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM: Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol 2010;24:1413-1422. (* co-first author). PMID: 20444886 8. Patsouris D, Li PP*, Thapar D, Chapman J, Olefsky JM, Neels JG: Ablation of CD11c- positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008;8:301-309. (* co-first author). PMID: 18840360 9. Li PP, Shan S, Chen YT, Ning ZQ, Sun SJ, Liu Q, Lu XP, Xie MZ, Shen ZF: The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Br J Pharmacol 2006;148:610-618. PMID: 16751799 10. Baeza-Raja, B., Sachs, B. D., Li, P., Christian, F., Vagena, E., Davalos, D., Le Moan, N., Ryu, J. K., Sikorski, S. L., Chan, J. P., Scadeng, M., Taylor, S. S., Houslay, M. D., Baillie, G. S., Saltiel, A. R., Olefsky, J. M., and Akassoglou, K. (2016) p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell reports 14, 255-268. PMID: 26748707 11. Bernardo, B., Lu, M., Bandyopadhyay, G., Li, P., Zhou, Y., Huang, J., Levin, N., Tomas, E. M., Calle, R. A., Erion, D. M., Rolph, T. P., Brenner, M., and Talukdar, S. (2015) FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance. Scientific reports 5, 11382. PMID: 26153793 12. Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh da, Y., Izquierdo, C. L., Chung, H., Li, P., Traves, P. G., Bandyopadhyay, G., Pessentheiner, A. R., Ofrecio, J. M., Cook, J. R., Qiang, L., Accili, D., and Olefsky, J. M. (2015) Adipocyte SIRT1 knockout promotes PPARgamma activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Molecular metabolism 4, 378-391. PMID: 25973386 13. Lu, M., Li, P., Bandyopadhyay, G., Lagakos, W., Dewolf, W. E., Jr., Alford, T., Chicarelli, M. J., Williams, L., Anderson, D. A., Baer, B. R., McVean, M., Conn, M., Veniant, M. M., and Coward, P. (2014) Characterization of a novel glucokinase activator in rat and mouse models. PloS one 9, e88431. PMID: 24533087 14. Lu, M., Sarruf, D.A., Li, P., Osborn, O., Sanchez-Alavez, M., Talukdar, S., Chen, A., Bandyopadhyay, G., Xu, J., Morinaga, H., et al. (2013). Neuronal sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. The Journal of biological chemistry 288, 10722-10735. PMID: 23457303 15. Reilly, S. M., Chiang, S. H., Decker, S. J., Chang, L., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J., White, N. M., Hochberg, I., Downes, M., Yu, R. T., Liddle, C., Evans, R. M., Oh, D., Li, P., Olefsky, J. M., and Saltiel, A. R. (2013) Nat Med 19, 313-321. PMID: 23396211 16. Jonker, J.W., Suh, J.M., Atkins, A.R., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.Q., Phillips, C.T., et al. (2012). A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485, 391-394. PMID: 22522926 17. Osborn, O., Oh, D.Y., McNelis, J., Sanchez-Alavez, M., Talukdar, S., Lu, M., Li, P., Thiede, L., Morinaga, H., Kim, J.J., et al. (2012). G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest 122, 2444-2453. PMID: 22653059 18. Talukdar, S., Oh da, Y., Bandyopadhyay, G., Li, D., Xu, J., McNelis, J., Lu, M., Li, P., Yan, Q., Zhu, Y., et al. (2012). Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med 18, 1407-1412. PMID: 22863787 19. Xu, J., Morinaga, H., Oh, D., Li, P., Chen, A., Talukdar, S., Lazarowski, E., Olefsky, J.M., and Kim, J.J. (2012). GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity. J Immunol 189, 1992-1999. PMID: 22778393 20. Nguyen, M. T., Chen, A., Lu, W. J., Fan, W., Li, P. P., Oh, D. Y., and Patsouris, D. (2012) Regulation of chemokine and chemokine receptor expression by PPARgamma in adipocytes and macrophages. PloS one 7, e34976 . PMID: 22529965

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