崔冰 - 中国医学科学院药物研究所 -

个人简介

2015.-至今：研究员，中国医学科学院北京协和医学院药物研究所。 2012-2015：助理项目科学家，美国加州大学圣迭戈分校(UCSD) 肿瘤中心。 2007-2012：博士后，美国加州大学圣迭戈分校(UCSD)肿瘤中心，肿瘤生物学。 2004-2007：博士，北京协和医学院药物研究所，分子免疫药理学。 2001-2004：硕士，中国药科大学，心血管药理学。 1996-2001：学士，中国药科大学，药理学专业。

研究领域

1. 肿瘤转移、肿瘤干细胞； 2. 非编码RNA在肿瘤生物学中的作用。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Cui B*, Chen L*, Chen G, Lei B, Mraz M, Salcedo M, Rassenti L, Messer M, Calin GA, Croce CM, Kipps TJ. MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. ( * co-first author) Blood (2014); 124(4):546-54. 2. Zhang S*, Cui B*, Lai H, Christina W, Liu G, Widhopf GF II , Wu RR, Lao F, Schwab R, Carson D, Kipps TJ. Depletion of ovarian cancer initiating cells by a monoclonal antibody against ROR1. (2014) ( * co-first author) Proc Natl Acad Sci U S A (2014);111(48):17266-71. 3. Widhopf II GF *, Cui B*, Ghia, EM, Chen LG, Messer K, Shen ZX, Briggs SP, Croce CM, Kipps TJ, ROR1 Can Interact With TCL1 And Enhance Leukemogenesis in Eµ-TCL1 Transgenic Mice. (2014) (* co-first author) Proc Natl Acad Sci U S A 2014;111(2):793-798. 4. Cui B*, Zhang SP*, Chen LG, Yu JQ, Widhopf II GF, Fecteau JF, Rassenti LZ, Kipps TJ, Targeting ROR1 Inhibits Epithelial-Mesenchymal Transition and Metastasis. (2013) (* co-first author) Cancer Research 2013;73(12):3649-60. 5. Yan HM*, Cui B*, Zhang XW, Fu XM, Yan J, Wang XX, Lv XX, Chen Z, Hu ZW. Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm. (* co-first author) Acta Pharmaceutica Sinica B 2015;5(3):176-187 6. Cui B, Cheng YS, Dai DZ, Li N, Zhang TT, Dai Y. CPU0213, a non-selective ETA/ETB receptor antagonist, improves pulmonary arteriolar remodeling of monocrotaline-induced pulmonary hypertension in rats. Clin Exp Pharmacol Physiol. 2009;36(2):169-175. 7. Yang HZ*, Cui B*, Liu HZ, Mi S, Yan J, Yan HM, Hua F, Lin H, Cai WF, Xie WJ, Lv XX, Wang XX, Xin BM, Zhan QM, Hu ZW. Blocking TLR2 activity attenuates pulmonary metastases of tumor. (* co-first author) PLoS One. 2009;4(8):e6520. 8. Yang HZ*, Cui B*, Liu HZ, Chen ZR, Yan HM, Hua F, Hu ZW. Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment. (* co-first author) J Immunol. 2009;182(1):692-702. 9. Cui B, Hu ZW. [The advances of the drug therapy for pulmonary fibrosis]. Progress in Physiological Sciences. 2008;39(3):233-238. (Chinese) 10. Cui B, Yu F, Dai DZ, Zhang TT, Tang XY, Dai Y. CPU0123, a novel endothelin receptor antagonist, relieves hypoxic pulmonary hypertension in rats by suppressing excessive ET-ROS pathway. Drug Development Research. 2007;68(1):42-50. 11. Cui B, Dai DZ. [Advances in drug treatment of pulmonary hypertension]. Progress in Pharmaceutical Sciences 2004; 28(4): 149-153. (Chinese) 12. Yu J, Chen LG, Cui B, Widhopf GF II, Shen ZX, Wu RR, Zhang L, Zhang SP, Briggs SP, Kipps TJ. Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation. J Clin Invest. 2016 Feb;126(2):585-98. 13. Choi MY, Widhopf GF 2nd, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J,Prussak C, Carson DA, Jamieson C, Kipps TJ. Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Clin Lymphoma Myeloma Leuk. 2015 Jun;15 Suppl:S167-9. 14. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW. TRB3 links insulin/IGF to tumor promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun. 2015 Aug 13;6:7951. 15. Fecteau JF, Corral LG, Ghia EM, Gaidarova S, Futalan D, Bharati IS, Cathers B, Schwaederlé M, Cui B, Lopez GA, Messmer D, and Kipps TJ. Lenalidomide Inhibits The Proliferation Of Chronic Lymphocytic Leukemia Cells Via A Cereblon/p21waf1/Cip1-Dependent Mechanism Independent Of Functional p53. (2014) Blood 2014, Jul 2. pii: blood-2014-03-559591. 16. Fecteau J, Messmer D, Zhang S, Cui B, Chen L, Kipps TJ. IF Of Oxygen Concentration On Mesenchymal Stromal Cells Isolated From The Marrow Of Patients With Chronic Lymphocytic Leukemia. Blood. 2013;121(6):971-4. 17. Zhang S, Wu CC, Fecteau JF, Cui B, Chen L, Zhang L, Wu R, Rassenti L, Lao F, Weigand S, Kipps TJ. Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44. Proc Natl Acad Sci U S A. 2013;110(15):6127-32. 18. Yang HZ, Wang JP, Mi S, Liu HZ, Cui B, Yan HM, Yan J, Li Z, Liu H, Hua F, Lu W, Hu ZW. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol. 2012;180(1):275-292. 19. Zhang S, Chen L, Cui B, Chuang HY, Yu J, Wang-Rodriguez J, Tang L, Chen G, Basak GW, Kipps TJ. ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS One. 2012;7(3):e31127. 20. Zhang S, Chen L, Wang-Rodriguez J, Zhang L, Cui B, Frankel W, Wu R, Kipps TJ. The Onco-Embryonic Antigen ROR1 Is Expressed by a Variety of Human Cancers. Am J Pathol. 2012; 181(6):1903-10.