张天泰 - 中国医学科学院药物研究所 -

个人简介

教育背景 2000.9 - 2003.6，中国药科大学药学院，理学博士 1995.9 - 1998.6，兰州大学医学院（原兰州医学院），医学硕士 1988.9 - 1993.6，兰州大学公共卫生学院（原兰州医学院预防医学系），医学学士工作经历 2006.4 - 至今，中国医学科学院药物研究所，副研究员、研究员 2003.9 - 2006.3，中国医学科学院药物研究所，博士后 1998.7 - 2003.8，兰州大学第一医院，主治医师、副主任医师 1993.7 - 1995.8，甘肃省疾病预防与控制中心，住院医师

研究领域

1. 炎症相关疾病中JAK-STAT信号通路激活的分子机制及调控研究； 2. 基于非受体酪氨酸激酶（JAK）的小分子先导物发现； 3. 炎症因子介导的神经炎症在AD中的发病机制研究。

近期论文

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1. D Zhang, C Huang, WY Xin, XW Ma, WK Zhang, TT Zhang*, GH Du*. Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-β-D - lactoside in rats using LC-MS/MS and Q-TOF-MS methods. J Pharm Biomed Anal, 2015, 109:1-10. 2. X Zhang#, JL Sun#, WY Xin#, YJ Li, L Ni, XW Ma, D Zhang, DM Zhang, TT Zhang*, GH Du*. Anti-inflammation effect of Methyl salicylate 2-O-β-D–lactoside on adjuvant induced-arthritis rats and lipopolysaccharide (LPS)-treated murine macrophages RAW264.7 cells. Int Immunopharmacol. 2015, 25(1): 88 - 95. 3. WY Xin, C Huang, X Zhang, S Xin, YM Zhou, XW Ma, D Zhang, YJ Li, SB Zhou, DM Zhang, TT Zhang*, GH Du*. Methyl Salicylate Lactoside Inhibits Inflammatory Response and Joint Destruction on Fibroblast-like Synoviocytes and Collagen-Induced Arthritis Mice. Br J Parmacol, 2014, 171:3526-3538. 4. Liu R, Li JZ, Song JK, Zhou D, Huang C, Bai XY, Xie T, Zhang X, Li YJ, Zhang L, Li L, Zhang TT*, Du GH*. Pinocembrin improves congnitive functions and protects the neurovascular unit in Aizheimer’s disease-related deficits. Neurobiol Aging, 2014, 35:1275-85. 5. D Zhang, XW Ma, WY Xin, C Huang, WK Zhang, TT Zhang*, GH Du*. Pharmacokinetics of Methyl salicylate-2-O-β-D-lactoside, a novel salicylic acid analog isolated from Gaultheria yunnanensis, in Dogs. Biomed Chromatography, 2013, 27:1680-1684. 6. Xin W, Huang C, Zhang X, Zhang G, Ma X, Sun L, Wang C, Zhang D, Zhang T*, Du G*. Evaluation of the new anti-inflammatory compound ethyl salicylate 2-O-β-d-glucoside and its possible mechanism of action. Int Immunopharmacol. 2013,15:303-308. 7. Liu R, Zhang T-T, Zhou D, Bai X-Y, Zhou W-L, Huang C, Song J-K, Wu C-X, Li L, Du G-H*. Quercetin protects against the Aβ(25-35)-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU. Neuropharmacol. 2013, 67:419-431. 8. Bai YY, Sun L, Du LD, Zhang TT, Xin WY, Du GH*. Association of circulating levels of asymmetric dimethylarginine (ADMA) with carotid intima-media thickness: Evidence from 6168 participants. Ageing Res Rev 2013, 12:699-707. 9. Zhang T, Sun L, Liu R, Zhang D, Lan X, Huang C, Xin W, Wang C, Zhang D, Du G. A novel naturally-occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages. Mol Pharmaceut. 2012, 9(3) :671-677. 10. Liu R, Wu C-X, Zhou D, Yang F, Tian S, Zhang L, Zhang TT, Du GH*. Pinocembrin protects against beta-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis. BMC Med. 2012, 10(1):105. 11. Lan X, Liu R, Sun L, Zhang T*, Du G*. Methylsalicylate 2-O-beta-D-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes. J Neuroinflamm. 2011, 8:98.