方莲花 - 中国医学科学院药物研究所 -

个人简介

教育背景 1985年毕业于沈阳药科大学药学系，获学士学位；1997~2002年在韩国忠北国立大学医科大学药理学专业学习，先后获医学硕士学位、博士学位。工作经历 1985年7月开始在吉林省延边大学医学院附属医院药剂科工作，任药师、主管药师。2004年开始在中国医学科学院北京协和医学院药物研究所药物筛选中心工作，先后任助理研究员、副研究员和研究员。

研究领域

专业研究领域为心脑血管药理学与新药发现，重点研究以心脑血管疾病为主的新药高通量筛选的药物靶点的确认、筛选模型的建立、筛选技术的研究，尤其是通过高通量筛选获得的活性化合物的深入评价及作用机制研究。

近期论文

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[1] Yuan Tian-Yi, Yan Yu, Wu Yu-Jie, Xu Xiao-Na, Li Li, Jiao Xiao-Zhen, Xie Ping, Fang Lian-Hua*, Du Guan-Hua*. Vasodilatory effect of a novel Rho-kinase inhibitor, DL0805-2, on the rat mesenteric artery and its potential mechanisms. Cardiovasc Drugs Ther, accepted, 2014. DOI: 10.1007/s10557-014-6544-7. [2] Guo Jing, Wang Shou-Bao, Yuan Tian-Yi, Wu Yu-Jie, Yan Yu, Li Li, Xu Xiao-Na, Gong Li-li, Qin Hai-lin, Fang Lian-Hua*, Du Guan-Hua*. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis, 2013, 231:384-391. [3] Guo Jing, Li Li, Wu Yu-Jie, Yan Yu, Xu Xiao-Na, Wang Shou-Bao, Yuan Tian-Yi, Fang Lian-Hua*, Du Guan-Hua*. Inhibitory effects of Brazilin on the vascular smooth muscle cell proliferation and migration induced by PDGF-BB. Am J Chin Med, 2013, 41(6): 1283-1296. [4] Gong Li-Li, Fang Lian-Hua, Wang He-Yao, Peng Jian-Hao, Si Kun, Zhu Jin, Han Fei-Fei, Wang Yue-Hua, Du Guan-Hua*, Pei Li-Xia, Liu Li-Hong*. Genetic risk factors for glucocorticoid-induced osteonecrosis: a meta-analysis. Steroids, 2013, 78: 401-408. [5] Gong Li-Li, Peng Jian-Hao, Fang Lian-Hua*, Xie Ping, Si Kun, Jiao Xiao-Zhen, Wang Li-Ping, Du Guan-Hua*. The vasorelaxant mechanisms of a Rho kinase inhibitor DL0805 in rat thoracic aorta. Molecules, 2012, 17(5): 5935-5944. [6] Gong Li-Li, Fang Lian-Hua*, Wang Su-Bo, Sun Jia-Lin, Qin Hai-Lin, Li Xiao-Xiu, Wang Shou-Bao, Du Guan-Hua*. Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis, 2012, 222(1): 50-58. [7] Gong Li-Li, Fang Lian-Hua*, Qin Hai-Lin, Lv Yang, Du Guan-Hua*. Analysis of the mechanisms underlying the vasorelaxant action of coptisine in rat aortic rings. Am J Chin Med, 2012, 40(2): 309-320. [8] Gong Li-Li, Fang Lian-Hua*, Peng Jian-Hao, Liu Ai-Lin, Du Guan-Hua*. Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. J Biotechnol, 2010, 145: 295-303. [9] Yang Xiu-Ying, Zhu Xiao-Ming, Chen Bai-Nian, Qiang Gui-Fen, Fang Lian-Hua, Du Guan-Hua* Establishment of GPCR expression cell lines using SNAP-tag technology: a case example of Urotensin II receptor. Life Sci J, 2013, 10(4): 2519-2525. (2012 IF 0.168) [10] Wang Shou-Bao, Pang Xiao-Bin, Gao Mei, Fang Lian-Hua, Du Guan-Hua*. Pinocembrin protects rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids. Chin J Nat Med, 2013, 11(3): 207-213. [11] Wang Shou-bao, Zhang Wei-ku, Pang Xiao-bin, Li Li, He Guo-rong, Yang Xiu-ying, Fang Lian-hua, Zhang Jun-tian, Du Guan-hua*. EETs mediate cardioprotection of salvianolicacids through MAPK signaling pathway. Acta Pharmaceutica Sinica B, 2013, 3(1): 25-31.