刘艾林 - 中国医学科学院药物研究所 -

个人简介

教育背景 2005年－2009 年在澳门大学中华医药研究院学习，获生物医药博士学位 1992年－1995 年于南开大学化学系学习，获理学硕士学位 1985年－1989 年在厦门大学化学系学习，获理学学士学位工作经历 2010年至今，中国医学科学院药物研究所研究员 2002年—2010年，中国医学科学院药物研究所副研究员 1996年—2002年，中国医学科学院药物研究所助理研究员 1995年—1996年，中国医学科学院药物研究所实习研究员 1989年—1992年，山东省济宁市第三制药厂助理工程师

研究领域

1. 抗阿尔茨海默病新药发现与机制研究 2. 抗流感新药发现与机制研究 3. 计算药理学：网络药理学研究，虚拟药物筛选与发现，药物信息学

近期论文

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1. Zu M#, Li C#, Fang JS, Lian WW, Liu AL*, Zheng LS*, Du GH*. Drug discovery of host CLK1 inhibitors for influenza treatment. Molecules, 2015, 20, 19735–19747. 2. Li C, Song X, Song J, Pang X, Wang Z, Zhang Y, Lian W, Liu A*, Du G*. Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobium clypearia Benth. in rats. Acta Pharmaceutica Sinica B, 2016, 6(1): 64-70. 3. Lian W, Fang J, Li C, Pang X, Liu AL*, Du GH*. Discovery of Influenza A virus neuraminidase inhibitors using support vector machine and Naïve Bayesian models. Mol Divers, 2015, DOI 10.1007/s11030-015-9641-z 4. Li C, Fang JS, Lian WW, Pang XC, Liu AL*, Du GH*. In vitro Antiviral Effects and 3D QSAR Study of Resveratrol Derivatives as Potent Inhibitors of Influenza H1N1 Neuraminidase. Chem Biol Drug Des. 2015, 85(4):427-38. 5. Kang J, Liu C, Wang H, Li B, Li C, Chen R* and Liu A*. Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth. Molecules 2014, 19: 4479-4490. 6. Dou J, Shi L, Hu A, Dong M, Xu J, Liu A, Jiang Y. Synthesis and evaluation of 2-(2 -arylmorpholino)ethyl esters of ibuprofen hydrochlorides as COX-2 and serotonin reuptake inhibitors. Arch Pharm (Weinheim). 2014, 347(2):89-95. 7. Li W, Xia L, Hu A*, Liu A*, Peng J, Tan W. Design and synthesis of 4-alkyl-2-amino (acetamino)-6-aryl-1,3-thiazine derivatives as influenza neuraminidase inhibitors. Arch Pharm (Weinheim). 2013, 346(9):635-44 8. Zu M, Yang F, Zhou W, Liu A*, Du G*, Zheng L*. In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives. Antiviral Res. 2012, 94: 217-224. 9. Yang F, Zhou WL, Liu AL*, Qin HL, Lee SM, Wang YT, Du GH*. The Protective Effect of 3-Deoxysappanchalcone on In Vitro Influenza Virus-induced Apoptosis and Inflammation. Planta Med. 2012, 78:968-973. (IF=2.369) 10. Zhan P, Wang L, Liu H, Chen X, Li X, Jiang X, Zhang Q, Liu X, Pannecouque C, Naesens L, De Clercq E, Liu A, Du G. Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents. Arch Pharm Res. 2012, 35(6):975-86.(IF=1.592) 11. Liu B, Deng AJ, Yu JQ, Liu AL, Du GH, Qin HL. Chemical constituents of the whole plant of Elsholtzia rugulosa. J Asian Nat Prod Res. 2012, 14(2):89-96. 12. Li Z, Zhan P, Naesens L, Vanderlinden E, Liu A, Du G, De Clercq E, Liu X. Synthesis and Preliminary Biologic Evaluation of 5-Substituted-2-(4-substituted phenyl)-1,3-Benzoxazoles as A Novel Class of Influenza Virus A Inhibitors. Chem Biol Drug Des. 2012, 79(6):1018-24. 13. Gao L, Zu M, Wu S, Liu AL*, Du GH*. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. Bioorganic & Medicinal Chemistry Letters, 2011, 21: 5964–5970. 14. Yu M, Liu A, Du G, Naesens L, Vanderlinden E, De Clercq E, Liu X. Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents. Chem Biol Drug Des. 2011, 78(4):596-602. 15. Liu Y, Zhang L, Gong J, Fang H, Liu A, Du G, Xu W. Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors. J Enzyme Inhib Med Chem. 2011, 26(4):506-13. 16. Zhang L, Cheng YX, Liu AL, Wang HD, Wang YL, Du GH*. Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa. Molecules. 2010, 15(11): 8507-8517. 17. Liu AL, Yang F, Zu M, Zhou D, Lee SM, Wang YT, Du GH. In Vitro anti-influenza viral activities of stilbenoids from the Lianas of Gnetum pendulum. Planta Med, 2010, 76: 1874-1876. 18. Liu AL, Shu SH, Qin HL, Lee SM, Wang YT, Du GH. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. Planta Medica, 2009, 75(4): 337-339. 19. Liu AL, Liu B, Qin HL, Lee SM, Wang YT，Du GH. Anti-influenza Virus Activities of Flavonoids from the Medicinal Plant Elsholtzia rugulosa. Planta Medica, 2008, 74: 746-51. 20. Liu AL, Wang HD, Lee SM, Wang YT, Du GH. Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorganic & Medicinal Chemistry, 2008, 16: 7141-7147.