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心脑血管创新药物药效筛选评价关键技术和分子机制研究
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1.Yang L., Fan B., Yang K., Zhu H.B. A simple and sensitive method for lipoprotein and lipids profiles analysis of individual micro-liter scale serum samples. Chem Phys Lipids 2012;165:133-141.
2. Guo P., Lian Z.Q., Sheng L.H., Wu C.M., Gao J., Li J., Wang Y., Guo Y.S., Zhu H.B. The adenosine derivative 2',3',5'-tri-o-acetyl-n6-(3-hydroxylaniline) adenosine activates ampk and regulates lipid metabolism in vitro and in vivo. Life Sci 2012;90:1-7
3. Huang L.Z., Zhu H.B. Novel LDL-oriented pharmacotherapeutical strategies. Pharmacol Res 2012;65(4):402-410
4.Sun Y., Lian Z.Q., Jiang C.Y., Wang Y.H., Zhu H.B. Beneficial metabolic effects of 2’,3’,5’-tri-acetyl-n6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters. PLoS ONE 2012;7(3):e32115
5.Sun Y., Wang Y.H., Qu K., Zhu H.B. Beneficial effects of cordycepin on metabolic profiles of liver and plasma from hyperlipidemic hamsters. J Asian Nat Prod Res 2011;13:534-546
6.Shao M., Qu K., Liu K., Zhang Y., Zhang L., Lian Z., Chen T., Liu J., Wu A., Tang Y., Zhu H.B. Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits. Planta Med 2011;77:809-816
7.Liu Y., He J., Abliz Z., Zhu H.B. In vitro stability and metabolism of o2', o3', o5'-tri-acetyl-n6-(3-hydroxylaniline) adenosine in rat, dog and human plasma: Chemical hydrolysis and role of plasma esterases. Xenobiotica 2011;41:549-560
8. Lian Z., Li Y., Gao J., Qu K., Li J., Hao L., Wu S., Zhu H.B. A novel ampk activator, ws070117, improves lipid metabolism discords in hamsters and HepG2 cells. Lipids Health Dis 2011;10:67
9.Zhang Y.Q., Tang Y., Wu A.L., Zhu H.B. Salvianolic acid a displays cardioprotective effects in in vitro models of heart hypoxia/reoxygenation injury. J Asian Nat Prod Res 2010;12:899-915
10.Wang Z., Wang X., Qu K., Zhu P., Guo N., Zhang R., Abliz Z., Yu H., Zhu H.B. Binding of cordycepin monophosphate to amp-activated protein kinase and its effect on amp-activated protein kinase activation. Chem Biol Drug Des 2010;76:340-344
11.Wang T., Liu Y.Y., Wang X., Yang N., Zhu H.B., Zuo P.P. Protective effects of octacosanol on 6-hydroxydopamine-induced parkinsonism in rats via regulation of prongf and ngf signaling. Acta Pharmacol Sin 2010;31:765-774
12. Niu Y.J., Tao R.Y., Liu Q., Tian J.Y., Ye F., Zhu P., Zhu H.B. Improvement on lipid metabolic disorder by 3'-deoxyadenosine in high-fat-diet-induced fatty mice. Am J Chin Med 2010;38:1065-1075
13.Guo P., Kai Q., Gao J., Lian Z.Q., Wu C.M., Wu C.A., Zhu H.B. Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of amp-activated protein kinase. J Pharmacol Sci 2010;113:395-403
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