个人简介
1993年 获国费奖学金 赴日攻读博士
1997年3月 于日本 国立 琦玉大学 获博士学位(Ph. D)
1997.04― 日本 三菱公司 生命科学研究所 博士后 / 外国人研究员
2000.04― 日本 理化研究所 前沿研究部门 研究员
2002.08― 日本 北里大学 医学院 客座教授（Visiting Professor）
2001.09― 中国医学科学院 药物研究所 研究员
2013.05― 中国医学科学院 神经科学中心 副主任
研究领域
1、抗神经退行性疾病（PD/AD）创新药物研发及机制分析;
2、荧光可视化技术在神经精神系统药物研究中的应用;
3、抗抑郁症创新药物研发及机制分析；
4、抗脑缺血创新药物研发及机制研究;
5、基于CKLF1为靶点的创新药物研发及机制分析;
6、天然产物及中药创新药物的发现及作用机制研究。
近期论文
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1. Chen J#, Wang ZZ, Zuo W, Zhang S, Chu SF, Chen NH*. Effects of chronic mild stress on behavioral and neurobiological parameters-Role of glucocorticoid. Horm Behav 2015; 78: 150-159.
2. Zuo W#, Zhang W#, Han N, Chen NH*. Compound IMM-H004, a Novel Coumarin Derivative, Protects against CA1 Cell Loss and Spatial Learning Impairments Resulting from Transient Global Ischemia. CNS Neurosci Ther 2015; 21: 280-288.
3. Zhang S#, Shao SY, Song XY, Xia CY, Yang YN, Zhang PC*, Chen NH*. Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity. Neurotoxicology 2015; 52:72-83.
4. Yuan YH#, Yan WF, Sun JD, Huang JY, Mou Z, Chen NH*. The molecular mechanism of rotenone-induced a-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway. Toxiol Lett 2015; 233(2): 163-171.
5. Song LK#, Ma KL, Yuan YH, Mu Z, Song XY, Niu F, Han N, Chen NH*. Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse. PLoS One 2015; 10(6): e0131281.
6. Liu Y#, Sun JD, Song LK, Li J, Chu SF, Yuan YH, Chen NH*. Environment-contact administration of rotenone: A new rodent model of Parkinson’s disease. Behav Brain Res 2015; 294: 149-161.
7. Gao Y#, Chu S, Li J, Li J, Zhang Z, Xia C, Heng Y, Zhang M, Hu J, Wei G, Li Y, Chen N*. Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway. J Ethnopharmacol 2015; 173: 231-240.
8. Gao Y#, Chu SF, Li JP, Zhang Z, Yan JQ, Wen ZL, Xia CY, Mou Z, Wang ZZ, He WB, Guo XF, Wei GN, Chen NH*. Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease. Acta Pharmacol Sin 2015; 36(3): 311-322.
9. Song XY#, Xu S#, Hu JF, Tang J, Chu SF, Liu H, Han N, Li JW, Zhang DM, Li YT*, Chen NH*. Piperine prevents cholesterol gallstones formation in mice. Eur J Pharmacol 2015; 751: 112-117.
10. Xia CY#, Zhang S, Gao Y, Wang ZZ, Chen NH*. Selectively modulate microglia polarization to M2 phenotype for stroke treatment. Int Immunopharmacol 2015; 25(2015): 377-382.
11. Yan WF#, Shao QH, Zhang DM, Yuan YH*, Chen NH*. The molecular mechanism of polygalasaponin F-mediated decreases in TNF α: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. J Asian Nat Prod Res 2015; 17(6): 662-670.
12. He WB#, Zhang JL, Chen NH*. Protein kinase-based neural signaling pathways for ginsenosides: a retrospective review. J Tradit Chin Med 2015; 35(3): 349-354.2014.
13. Kong LL#, Wang ZY, Han N, Zhuang XM, Wang ZZ, Li H*, Chen NH*. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. J Neuroinflammation 2014; 11:112.
14. Yan JQ#, Yuan YH, Gao YN, Huang JY, Ma KL, Gao Y, Zhang WQ, Guo XF, Chen NH*. Overexpression of Human E46K Mutant alpha-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway. Mol Neurobiol 2014; 50(2): 685-703.
15. Zuo W#, Zhang S, Xia CY, Guo XF, He WB, Chen NH*. Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: The role of inhibition of Drp1 in ischemic brain damage. Neuropharmacology 2014; 86C: 103-115.
16. Ma KL#, Song LK, Yuan YH, Zhang Y, Han N, Gao K, Chen NH*. The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle. Neuropharmacology 2014; 82: 132-142.
17. Zhang Z#, Zhang Y, Mou Z, Chu SF, Chen XY, He WB, Guo XF, Yuan YH, Takahashi M, Chen NH*. Tyrosine 402 phosphorylation of pyk2 is involved in ionomycin-induced neurotransmitter release. PLoS One 2014; 9: e94574.
18. Zuo W#, Chen J, Zhang S, Tang J, Liu H, Zhang D, Chen N*. IMM-H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA-and PI3K-dependent Akt activation. Eur J Neurosci 2014; 39: 2107-2118.
19. Kong LL#, Wang ZY, Hu JF, Yuan YH, Han N, Li H, Chen NH*. Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect. Neurochem Int 2014; 76C: 91-98.
20. Zhang S#, Zuo W, Guo XF, He WB, Chen NH*. Cerebral glucose transporter: the possible therapeutic target for ischemic stroke. Neurochem Int 2014; 70: 22-29.
学术兼职
中国药理学会 副秘书长
中国药理学会 神经精神药理专业委员会 副主任委员
中国药理学会 补益药药理专业委员会 主任委员
北京市药理学会 神经精神药理专业委员会 主任委员
世界中医药联合会 网络药理学会 副理事长
全国中医药高等教育学会 中药教育研究会 副理事长
《神经药理学报》副主编
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