个人简介
1978—1982 年毕业于山东医科大学药学院，获学士学位。1986—1989 年毕业于同济医科大学，获医学硕士学位；1992— 1995 年毕业于北京协和医学院，获博士学位。1995—1998 年University of Liege, Belgium，博士后，研究神经生物化学。
研究领域
主要从事药物发现、高通量药物筛选、神经药理学和心脑血管药理学研究。
近期论文
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[1] Yang Xiu-Ying, Qiang Gui-Fen, Zhang Li, Zhu Xiao-Ming, Wang Shou-Bao, Sun Lan, Yang Hai-Guang, Du Guan-Hua*. Salvianolic acid A protects against vascular endothelial dysfunction in high-fat diet fed and streptozotocin-induced diabetic rats. J Asian Nat Prod Res. 2011, 13(10):884-894.
[2] Gao Li, Zu Mian, Wu Song, Liu Ai-Lin*, Du Guan-Hua*. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. Bioorg Med Chem Lett, 2011, 21(19), 5964-5970.
[3] Li L, Zhang HN, Chen HZ, Gao P, Zhu LH, Li HL, Lv X, Zhang QJ, Zhang R, Wang Z, She ZG, Zhang R, Wei YS, Du GH, Liu DP, Liang CC. SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res. 2011,108(10):1180-1189.
[4] Yang XY, Sun L, Xu P, Gong LL, Qiang GF, Zhang L, Du GH. Effects of salvianolic scid A on plantar microcirculation and peripheral nerve function in diabetic rats. Eur J Pharmacol. 2011, 665(1-3):40-46.
[5] Liu R., Meng F.-R., Zhang L., Liu A.-L., Qin H.-L., Lan X., Li L. and Du G.-H. Luteolin Isolated from the Medicinal Plant Elsholtzia rugulosa (Labiatae) Prevents Copper-Mediated Toxicity in β-Amyloid Precursor Protein Swedish Mutation Overexpressing SH-SY5Y Cells. Molecules. 2011, 16, 2084-2096.
[6] Zhang D, Liu R, Sun L, Huang C, Wang C, Zhang D-M, Zhang T-T, Du G-H. Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder. Molecules 2011, 16(5), 3875-3884.
[7] Shi LL, Chen BN, Gao M, Zhang HA, Li YJ, Wang L, Du GH. The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats. Life Sci. 2011, 88(11-12): 521-528.
[8] Mu X, He GR, Yuan X, Li XX, Du GH. Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice. Pharmacol Biochem Behav. 2011, 98(2): 286-291.
[9] Meng F, Liu R, Gao M, Wang Y, Yu X, Xuan Z, Sun J, Yang F, Wu C, Du G. Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats. Brain Res. 2011.1391:93-101.
[10] Lan. Sun, Tiantai Zhang, Xing Yu, Wenyu Xing, Xi Lan, Dan Zhang, Chao Huang, Guanhua Du. Asymmetric dimethylarginine confers the communication between endothelial and smooth muscle cells and leads to VSMC migration through p38 and ERK1/2 signaling cascade. FEBS Lett, 2011, 585(17):2727-2734.
[11] Wang C, Zhang TT, Du GH, Zhang DM. Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs.J Asian Nat Prod Res. 2011, 13(9):817-825.
[12] Chen XP, Sun FY, Ma LF, Wang JH, Qin HL, Du GH*. In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula Retz fruit. Indian J Pharmacol. 2011, 43(3):320-323.
[13] Mingyan Yu, Ailin Liu, Guanhua Du, Lieve Naesens, Evelien Vanderlinden, Erik De Clercq, Xinyong Liu*. Discovery of Dihydro-Alkyloxy-Benzyl- Oxopyrimidines as Promising Anti-Influenza Virus Agents. Chem Biol Drug Des. 2011, 78(4): 596-602.
[14] Xiaoxia Gao, Xingyu Zheng, Zhenyu Li, Yuzhi Zhou, Haifeng Sun, Lizeng Zhang, Xiaoqing Guo, GuanhuaDu, Xuemei Qin. Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry. J Ethnopharmacol. 2011, 137(1):690-699.
[15] Tian S, Du L-D, Wang S-B, He G-R, Yang T, Li X-X, Guo J, DU G-H. Pharmacokinetic Study of Baicalein and Its Major Metabolites after iv Administration in Dogs. Chinese Herbal Medicines (CHM), 2011, 3(3):196-201.
[16] 张莉，张维库，赵莹，杨秀颖，方莲花，王守宝，时丽丽，于晓彦，王夙博，杨海光，孙加琳，田硕，杜冠华*。丹酚酸A的研究与进展。中国中药杂志，2011，36(19)：2603-2609。
[17] 于晓彦，陈芊茜，白晓宇，田硕，孙加琳，吕扬*，杜冠华*。大鼠口服硫酸氢氯吡格雷的多晶型吸收特点研究。药学学报，2011，46(10)：1268-1272。
[18] 庞晓斌，谢欣梅，王守宝，杜冠华*。人源蛋白酪氨酸磷酸酶 (PTP1B) 抑制剂的高通量筛选。药学学报，2011，46(9)：1058-1064。
[19] 杜冠华。药物临床前研究与转化医学—实验动物的应用与动物实验。中国比较医学杂志，2011，21(10,11)：24-26。
[20] 白晓宇，杜冠华。抑郁症动物模型的转换研究。中国比较医学杂志，2011，21(10,11)：121-126,116。
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