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个人简介

教育情况: 1978.4-1982.7 佳木斯医学院医疗系医学专业学士 1985.8-1988.7 黑龙江中医学院基础药理学专业硕士 1992.8-1994.12 中国医学科学院/北京协和医学院药物研究所博士 工作经历: 1982.08-1985.07 佳木斯医学院基础部药理学教研室助教 1988.08-1992.07 佳木斯医学院基础部药理学教研室讲师 1995.01-1996.02 中国医学科学院/北京协和医学院药物研究所助研 1996.03-1996.11 日本大阪市立大学医学部第二生化学教室客员助教授 1996.12-1997.04 中国医学科学院/北京协和医学院药物研究所副研究员 1997.05-1997.08 瑞士Vaudois州立大学附属医院癌研究中心访问学者 1997.09-1999.09 中国医学科学院/北京协和医学院药物研究所副研究员 1999.10-2000.11 中国医学科学院/北京协和医学院药物研究所研究员 2000.12-2001.08 美国亨利福特医学中心福特医院神经科学访问学者 2001.09~中国医学科学院/北京协和医学院药物研究所研究员

研究领域

主要从事抗肿瘤药物的分子药理学研究及新药创制与开发,免疫调节剂的研究与开发

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Li Yan, Tang Ke, Li Chao, NiuFei, Zhou Wanqi, Yang Hanze, Feng Zhiqiang, Chen Xiaoguang. The molecular mechanisms of a novel multi-kinase inhibitor ZLJ33 in suppressing pancreatic cancer growth. Cancer Letter. 2015 Jan 28;392-403. 2. NiuFei, Li Yan, Lai Fangfang, Ni Lin, Ji Ming, Jin Jing, Yang Hanze, Wang Chao, Zhang Dongming, Chen Xiaoguang. LB-1 exerts antitumor activity in pancreatic cancer by inhibiting HIF-1α and Stat3 signaling. J Cell Physiol. 2015 Feb 5. doi: 10.1002/jcp.24949 3. Jing Jin, Jinping Hu, Wanqi Zhou, Xiaojian Wang, Qiong Xiao, Nina Xue, Dali Yin, Xiaoguang Chen. Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis. Biochemical Pharmacology. 2014;90:50-61. 4. Xue nina, Jin Jing, Liu Di, Zhang Sen, Yu xiaoming, Xiaoguang Chen. Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways. Curr Cancer Drug Targets. 2014;14(7):671-83. 5. Wang tianen, Wang yongkang, Jin Jing, Xu bailing, Chen xiaoguang. A novel derivative of quinazoline, WYK431 induces G2/M phase arrest and apoptosis in human gastric cancer BGC823 cells through the PI3K/Akt pathway. International Journal of Oncology.2014;45: 771-781. 6. Ke Tang, Can Luo, Yan Li, Chenshu Lu, Wanqi Zhou, Haihong Huang*, Xiaoguang Chen*. The study of a novel Sorafenib derivative HLC-080 as an antitumor agent. PLOS ONE. 2014;9(7),e101889. 7. Liwei Lang, Xiaoyu Liu, Yan Li, Qing Zhou, Ping Xie, Chunhong Yan*, Xiaoguang Chen*. A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth. PLOS ONE 2014;9(6)e99584. 8. Tian Yulin1, Jin Jing1, Wang Xiaojian, Hu jinping, Xiao Qiong, Zhou Wanqi, Chen Xiaoguang, Yin Dali. Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design. Eur J Med Chem. 2014 Oct 6;85:1-15. 9. Mei Mei, Dan Xie, Yi Zhang, Jing Jin, Feng You, Yan Li, Jungui Dai, Xiaoguang Chen. A New 2a,5a,10b,14b-tetraacetoxy-4(20),11-taxadiene(SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells. PLOS ONE. 2014;9 (8), e104317. 10. LU Chen-shu, TANG Ke, LI Yan, JIN Bo, YIN Da-li, MA Chen, CHEN Xiaoguang*, HUANG Hai-hong*. Synthesis and in vitro antitumor activities of novel benzyl urea analogues of sorafenib. ActaPharmaceuticaSinica, 48(5), 709-717, 2013 11. Sen Zhang, Hongqi Xin, Yan Li, Dongming Zhang, Jing Shi, Jingzhi Yang, Xiaoguang Chen*. Skimmin,aCoumarin from Hydrangea paniculata,Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition。Evidence-Based Complementary and Alternative Medicine. :ID 819296, 2013 12. Chunwan Lu, Di Liu, Jing Jin, HemantkumarDeokar, Yi Zhang, John Buolamwini, Xiaoming Yu, Chunhong Yan, Xiaoguang Chen*. Inhibition of gastric tumor growth by a novel Hsp90 inhibitor. Biochemical Pharmacology, 85:1246-1256,2013 13. Jing Jin, Yi Zhang, Yan Li, Haijing Zhang, Hongyan Li, Xia Yuan, Xiangyan Li, Wanqi Zhou, Bailing Xu, Chongjing Zhang, Zhihui Zhang, Lina Zhu, Xiaoguang Chen*.RNA-interference-mediated downregulation of Pin1 suppresses tumorigenicity of malignant melanoma A375 cells.Neoplasma, 60(1):92-100, 2013 14. Jie Zhou1, Jing Jin1, Yi Zhang, Yuwen Yin, Xiaoguang Chen, Bailing Xu. Synthesis and antiproliferative evaluation of novel benzoimidazolecontainedoxazole-bridged analogs of combretastatin A-4.European Journal of Medicinal Chemistry. 68:222-232, 2013 15. Zhang Sen, Li Yan, Li Hongyan, Zheng Xuguang, Chen Xiaoguang*. Renal.protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. Biomedical Reports. 1:34-40, 2013 16. Zhang Sen, Li Hongyan, Li Yan, Zhang Furong, Liu Yue, Chen Xiaoguang*. Nicousamide normalizes renovascular hypertension in two-kidney one-clip hypertensive rats. Biomedical Reports. 1:89-92, 2013 17. Zhang Sen, Yang Jingzhi, Li Hongyan, Li Yan, Liu Yue, Zhang Dongming, Zhang Furong, Zhou Wanqi, Chen Xiaoguang*.Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats.European Journal of Pharmacology.692:78-83, 2012 18. Li Yan, Zhou Wanqi, Lang Liwei, Jin Jing, Tang Ke, Li Chao, Bin Tena T, Chen Xiaoguang*.The effect of Aurora kinases on cell proliferation,cell cycle regulation and metastasis in renal cell carcinoma. International Journal of Oncology. 41(6) , 41(6):2139-49, 2012 19. Liu Chang1, Jin Jing1, Chen Liang, Zhou Jie, Chen Xiaoguang, Fu Decai, Song Hongrui, Xu Bailing.Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorganic & Medicinal Chemistry. 20:2992-2999, 2012 20. Qing Zhou, Yan Li, Jing Jin, Liwei Lang, Zhixiang Zhu, Weishuo Fang, Xiaoguang Chen*.Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo. Biol. Pharm. Bull. 35(12), 2170-2179, 2012

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