个人简介

1996 – 2000 沈阳药科大学，化学制药，学士 2000 – 2003 沈阳药科大学，药物化学， 硕士 2005 – 2008 北京协和医学院，药物化学，博士

研究领域

研究方向一：基因-化学-功能导向的活性天然产物的发现 研究方向二：活性天然产物的生物合成和合成生物学

领域： 天然药物化学+合成生物学 1. 基因-化学-功能导向的活性天然产物的发现： 利用生物技术挖掘并激活微生物（尤其是真菌）中的沉默基因，发现常规实验条件下难以产生的活性化合物。 2. 活性天然产物的生物合成和合成生物学： 解析结构独特的活性天然产物的生物合成途径，积累合成生物学元件；通过合成生物学技术对活性化合物进行结构优化。

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Daojiang Yan#, Qibin Chen#, Jie Gao#, Jian Bai, Bingyu Liu, Yalong Zhang, Le Zhang, Chen Zhang, Yi Zou, and Youcai Hu*, Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids, Organic Letters, 2019, 21 (5), 1475-1479. 2. Shu-Shan Gao#, Tao Zhang#, Marc Garcia-Borras, Yiu-Sun Hung, John M. Billingsley, K. N. Houk*, Youcai Hu* and Yi Tang*. Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide, Journal of the American Chemical Society, 2018, 140, 6991-6997. 3. Jian Bai, Rong Mu, Man Dou, Daojiang Yan, Bingyu Liu, Qian Wei, Jun Wan, Yi Tang, Youcai Hu*. Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids. Acta Pharmaceutica Sinica B. 2018, 8(4):687-697. 4. Tao Zhang#, Jun Wan#, Zhajun Zhan, Jian Bai, Bingyu Liu, Youcai Hu*.Activation of an Unconventional Meroterpenoid Gene Cluster in Neosartorya glabra Leads to the Production of New Berkeleyacetals. Acta Pharmaceutica Sinica B. 2018, 8(3):478-487. 5. Jian Bai#, Daojiang Yan#, Tao Zhang, Yongzhi Guo, Yunbao Liu, Yi Zou, Mancheng Tang, Bingyu Liu, Qiong Wu, Shishan Yu*, Yi Tang*, and Youcai Hu*, A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A, Angewandte Chemie International Edition. 2017, 56，4782-4786. 6. Xu-Ming Mao, Wei Xu, Dehai Li, Wen-Bing Yin, Yit-Heng Chooi, Yong-Quan Li, Yi Tang,* and Youcai Hu*. Epigenetic Genome Mining of an Endophytic Fungus Leads to the Pleiotropic Biosynthesis of Natural Products. Angewandte Chemie International Edition. 2015, 54, 7592 –7596. 7. Youcai Hu, David Dietrich, Wei Xu, Ashay Patel, Justin A J Thuss, Jingjing Wang, Wen-Bing Yin, Kangjian Qiao, K N Houk, John C Vederas*, Yi Tang*. A Carbonate-forming Baeyer-Villiger monooxygenase, Nature Chemical Biology, 2014, 10, 552-554. 8. Youcai Hu#, Malia B. Potts#, Dominic Colosimo, Mireya L. Hererra-Hererra, Aaron G. Legako, Muhammed Yousufuddin, Michael A. White and John B. MacMillan*. Discoipyrroles A-D: Isolation, Structure Determination, and Synthesis of Potent Migration inhibitors from Bacillus hunanensis. Journal of the American Chemical Society, 2013, 135, 13387-13392. 9. Youcai Hu, Kezhan Wang, John B. MacMillan*, Hunanamycin A, an Antibiotic from a Marine-Derived Bacillus hunanensis, Organic Letters, 2013, 15, 390-393. 10. Malia B. Potts#, Hyun Seok Kim#, Kuit W. Fisher#, Youcai Hu#, Yazmin P. Carrasco, Gamze Betul Bulut, Yi-Hung Ou, Mireya L. Herrera-Herrera, Federico Cubillos, Saurabh Mendiratta, Guanghua Xiao, Matan Hofree, Trey Ideker, Yang Xie, Lily Jun-shen Huang, Robert E. Lewis*, John B. MacMillan* and Michael A. White*, Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products. Science Signaling, 2013, 6, RA90.

学术兼职

北京药学会第十六届理事会理事；北京药学会天然药物专业委员会副主任委员；中国菌物学会菌物化学专业委员会副主任委员；中国抗癌协会第一届北京中西医整合肿瘤专业委员会副主任委员；中国医疗保健国际交流促进会中药分会委员；国家卫健委抗生素生物工程重点实验室学术委员会委员；中国化学会会员；中国药学会高级会员。兼任《Acta Pharmaceutica Sinica B》、《Chinese Chemical Letters》、《Chinese Journal of Natural Medicines》、《药学学报》和《天然产物研究与开发》等专业期刊青年编委，《中国中药杂志》第十二届编委