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个人简介

教育背景: 1983.9-1987.7 北京大学化学系获理学士学位; 1987.9-1990.7 北京大学化学系有机化学专业获理学硕士学位; 1999.9-2002.7 中国医学科学院药物所药物化学专业获理学博士学位。 工作经历: 1990.7-1999.8 在河北省药物研究所工作,先后任工程师、高级工程师,课题组长,从事新药研究与开发工作; 1996.8-1997.7 在美国Georgia Institute of Technology化学与生物学院进修,从事可卡因拮抗剂的合成和毒瘾戒断活性的研究; 2002.7-现在 在中国医学科学院药物研究所工作,先后任副研究员、研究员,课题组长; 2005年任博士生导师。

研究领域

生物活性天然产物的合成,新药研究与开发。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Xuan Pan, Zhanzhu Liu*, The preparation of novel chiral auxiliaries SAMIQ/RAMIQ and their application in the asymmetric Michael addition, Tetrahedron, 2014, 70, 4602-4610 2. Ke Wang, Zhan-Zhu Liu*, Synthesis and cytotoxic activities of a series of novel N-methyl-bisindolylmaleimide amide derivatives, Journal of Asian Natural Products Research, 2014, 2014, 3, 296-303 3. Qiguo Feng, Lulu Tao, Zhanzhu Liu*, Total Synthesis of Microtubule-Stabilizing Agent Ceratamine A, The Journal of Organic Chemistry, 2013, 78, 12814-12818 4. Geng Xu, Ju Guo, Zheng Yan, Nan Wang, Zhan-Zhu Liu*,Synthesis and cytotoxicity of dinuclear platinum (II) complexes of (1S, 3S)- 1, 2, 3, 4-tetrahydroisoquinolines, Chinese Chemical Letters, 2013, 24, 186-188 5. Ju Guo, Wenfang Dong, Wei Liu, Zheng Yan, Nan Wang, Zhanzhu Liu*, Synthesis and cytotoxicity of 3-aryl acrylic amide derivatives of the simplified saframycin-ecteinascidin skeleton prepared from L-dopa, European Journal of Medicinal Chemistry, 2013, 62, 670-676. 6. Ke Wang, Zheng Yan, Nan Wang, Zhan Zhu Liu*, Synthesis and cytotoxic activities of a series of novel N-methyl- bisindolylmaleimide amino acid ester conjugates, Chinese Chemical Letters, 2012, 23, 462-465. 7. Wei Liu, Xiangwei Liao, Wenfang Dong, Zheng Yan, Nan Wang, Zhanzhu Liu*, Total synthesis and cytotoxicity of (-)-jorumycin and its analogues, Tetrahedron, 2012, 68, 2759-2764. 8. Wenfang Dong, Wei Liu, Zheng Yan, Xiangwei Liao, Baohe Guan, Nan Wang, Zhanzhu Liu*, Asymmetric synthesis and cytotoxicity of (–)-saframycin A analogues, European Journal of Medicinal Chemistry, 2012, 49, 239-244 9. Wenfang Dong, Wei Liu, Xiangwei Liao, Baohe Guan, Shizhi Chen, Zhanzhu Liu*, Asymmetric total synthesis of (–)-saframycin A from L-tyrosine, The Journal of Organic Chemistry, 2011, 76, 5363–5368 10. Wei Liu, Wenfang Dong, Xiangwei Liao, Zheng Yan, Baohe Guan, Nan Wang, Zhanzhu Liu* , Synthesis and cytotoxicity of (-)-renieramycin G analogues, Bioorganic & Medicinal Chemistry Letters, 2011,21, 1419-1421 11. YU Ran, ZHOU Yan-li, HUAN Yi, LIU Quan, SHEN Zhu-fang, LIU Zhan-zhu*, Design, Synthesis, and PPARα/γ Agonistic Activity of Novel Tetrahydroisoquinoline Derivatives, Acta Pharmaceutica Sinica, 2011, 46 (3), 311-316 (in Chinese) 12. Wei Liu, Wen Fang Dong, Xiang Wei Liao, Bao He Guan, Zhan Zhu Liu*, Synthesis of an Isomer of the Renieramycin Skeleton from L-Tyrosine, Journal of Heterocyclic Chemistry, 2011, 48, 414-418 13. Geng Xu, Zheng Yan, Nan Wang, Zhanzhu Liu*, Synthesis and cytotoxicity of cis-dichloroplatinum (II) complexes of (1S, 3S) - 1, 2, 3, 4-tetrahydroisoquinolines, European Journal of Medicinal Chemistry, 2011, 46, 356-363 14. Ke Wang, Zhan-Zhu Liu*, Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study, European Journal of Medicinal Chemistry, 2010, 45, 4175-4179 15. Liao Xiang-Wei, Dong Wen-Fang, Liu Wei, Chen Shi-Zhi, Liu Zhan-Zhu*, Synthetic Progress of the Tetrahydroisoquinoline Antitumor Alkaloids, Chinese Journal of Organic Chemistry, 2010, 3, 317-329 (in Chinese) 16. Geng Xu, Zhan Zhu Liu*, Enantioselective addition of diethylzinc to aryl aldehydes catalyzed by 1,2,3,4-tertrahydroisoquinoline β-amino alcohol, Chinese Chemical Letters, 2010, 21, 309-311 17. Ke Wang, Xiang-Yan Li, Xiao-Guang Chen, Zhan-Zhu Liu*, Synthesis and antitumor activity of bisindolylmaleimide and amino acid ester conjugates, Journal of Asian Natural Products Research, 2010, 12, 36-42 18. Xiang Wei Liao, Wen Fang Dong, Wei Liu, Bao He Guan, Zhan Zhu Liu*, Total Synthesis of (-)-MY 336a from L-Tyrosine, Journal of Heterocyclic Chemistry, 2010, 47, 50-53 19. Ke Wang, Zhanzhu Liu*, Synthesis of Arcyriarubin A and Arcyriaflavin A via Cross-coupling of Indolylboronic Acid with Dibromomaleimides, Synthetic Communications, 2010, 40, 144 - 150 20. Geng Xu, Zhan Zhu Liu*, Synthesis of New Chiral 1,2,3,4-Tertrahydroisoquinoline β-Amino Alcohol for Asymmetric Diethylzinc Addition to Aryl Aldehydes (І), Chinese Chemical Letters, 2009, 20, 1393-1396

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