Li, Xin - University of British Columbia - Michael Smith Laboratories

个人简介

Scientist, Maxygen. Inc. (1999-2001) Postdoctoral Fellow, Duke Univ., (1996-1999) Ph.D. Plant Pathology, Oklahoma State Univ., (1995) BSc. Genetics and Genetic Engineering, Fudan University (1989)

研究领域

The long-term goal of our research program is to understand the molecular mechanisms of plant innate immunity. We study plant defense against pathogen infection in the context of gene regulation, protein-protein interaction and signal transduction using the model organism Arabidopsis thaliana. Our program aims to discover new regulatory components of plant disease resistance and to elucidate the biochemical functions of a number of regulators we have already identified. Understanding the innate ability of plants to defend themselves against pathogen infection promises to revolutionize disease control practices in our fields using environmentally friendly strategies.

近期论文

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Xu F., Xu S., Wiermer M., Zhang Y. and Li X. 2012. The cyclin L homolog MOS12 and the MOS4-associated complex are required for proper splicing of plant resistance genes. Plant Journal, 70(6):916-28. Cheng Y.T. and Li X. 2012. Ubiquitination in NB-LRR-mediated immunity. Current Opinion in Plant Biology 15(4):392-99. Johnson K.C., Dong O.X., Huang Y., Li X. 2013. A Rolling Stone Gathers No Moss, but Resistant Plants Must Gather Their MOSes. Cold Spring Harb Symp Quant Biol. Feb 21.10.1101/sqb.2013.77.014738 Huang Y., Chen X., Liu Y., Rothe C., Copeland C., McFarlane H.E., Huang S., Lipka V., Wiermer M. and Li X. 2013. Mitochondrial AtPAM16 is required for plant survival and negative regulation of plant immunity. Nature Communications, 4:2558. doi: 10.1038/ncomms3558. Huang Y., Minaker S., Roth C., Hieter P., Lipka V., Wiermer M. and Li X. 2014. An E4 ligase facilitates polyubiquitination of plant immune receptor resistance proteins. Plant Cell 26(1):485-96. Huang S., Monaghan J., Zhong X., Lin L., Sun T., Dong O.X. and Li X. 2014. HSP90s are required for NLR immune receptor accumulation in Arabidopsis. Plant Journal 79(3):427-39. Xu F., Kapos P., Cheng Y.T., Li M., Zhang Y. and Li X. 2014. NLR-Associating Transcription Factor bHLH84 and Its Paralogs Function Redundantly in Plant Immunity. PLoS Pathog. 10(8):e1004312. doi: 10.1371/journal.ppat.1004312. Xu F., Cheng Y.T., Kapos P., Huang Y. and Li X. 2014. P-Loop-Dependent NLR SNC1 Can Oligomerize and Activate Immunity in the Nucleus. Mol Plant 7(12) 1801-1804. Xu F., Zhu C., Cevik V., Johnson K., Liu Y., Sohn K., Jones J.D., Holub E.B. and Li X. 2015. Autoimmunity conferred by chs3-2D relies on CSA1, its adjacent TNL-encoding neighbour. Sci Rep. 5:8792. doi: 10.1038/srep08792. Li X., Kapos P. and Zhang Y.. NLRs in plants. 2015. Curr Opin Immunol. 32C:114-121. doi: 10.1016/j.coi.2015.01.014. Xu F., Huang Y., Li L., Gannon P., Linster E., Huber M., Kapos P., Bienvenut W., Polevoda B., Meinnel T., Hell R., Giglione C., Zhang Y., Wirtz M., Chen S. and Li X. 2015. Two N-Terminal Acetyltransferases Antagonistically Regulate the Stability of a Nod-Like Receptor in Arabidopsis. Plant Cell 27(5):1547-62. Huang S., Chen X., Zhong X., Li M., Ao K., Huang J. and Li X.. 2016. Two redundant plant TRAF proteins participate in NLR immune receptor turnover. Cell Host & Microbe 19(2):204-15. Li X. and Zhang Y. Suppressor Screens in Arabidopsis. Methods Mol Biol. 2016;1363:1-8. doi: 10.1007/978-1-4939-3115-6_1. Dong O.X., Tong M., Bonardi V., Kasmi F.E., Woloshen V., Wünsch L.K., Dangl J.L. and Li X. TNL-mediated immunity in Arabidopsis requires complex transcriptional regulation of the redundant ADR1 gene family. New Phytologist 210(3):960-973. Johnson K.C.M., Yu Y., Gao L., Eng R.C., Wasteneys G.O., Chen X. and Li X. 2016. A partial loss-of-function mutation in an Arabidopsis RNA polymerase III subunit leads to pleiotropic defects. Journal of Experimental Botany 67(8):2219-30. Copeland C., Woloshen V., Huang Y. and Li X. 2016. AtCDC48A is involved in the turnover of an NLR immune receptor. Plant J. 2016 Jun 24. doi: 10.1111/tpj.13251. [Epub ahead of print] Huang S., Balgi A., Pan Y., Li M., Zhang X., Du L., Zhou M., Roberge M. and Li X. 2016. Identification of methylosome components as negative regulators of plant immunity using chemical genetics. Mol Plant. 9(12):1620-1633. Johnson KC, Zhao J, Wu Z, Roth C, Lipka V, Wiermer M, and Li X. 2017. The putative kinase substrate MUSE7 negatively impacts the accumulation of NLR proteins. Plant J. 89(6):1174-1183. Wu Z., Huang S., Zhang X., Wu D., Xia S. and Li X. 2017. Regulation of plant immune receptor accumulation through translational repression by a glycine-tyrosine-phenylalanine (GYF) domain protein. eLife 2017 Mar 31;6. pii: e23684 Tong M, Kotur T, Liang W, Vogelmann K, Kleine T, Leister D, Brieske C, Yang S, Lüdke D, Wiermer M, Zhang Y, Li X, Hoth S. 2017. E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by immune receptor SOC3. New Phytol. 215(4):1516-1532. Ding Y, Sun T, Ao K, Peng Y, Zhang Y, Li X, Zhang Y. 2018. Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity. Cell. 2018 Apr 11. pii: S0092-8674(18)30376-3. doi: 10.1016/j.Cell.2018.