李正球 - 暨南大学

个人简介

2010年毕业于中科院广州化学研究所获理学博士学位；2010年至2015年新加坡国立大学从事博士后研究工作。2015年9月加入暨南大学药学院，从事教学科研工作。

研究领域

主要围绕化学蛋白质组学技术开展创新药物发现研究，针对未满足临床需求的重大疾病开展靶标发现与新型先导化合物构建工作

近期论文

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Ma, N.; Hu, J.; Zhang, Z. M.; Liu,W.; Huang, M.; Fan, Y.; Yin,X.; Wang,J.;* Ding,K.;* Ye,W.-C.;*Li Z.*2H Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells J. Am. Chem. Soc.2020, 142, 6051-6059. Zhu D.;Guo, H.;Chang, Y.; Ni Y.; Li L.; Zhang, Z-M.; Hao, P.;* Xu, Y.; Ding K.;* and Li Z.*. Cell- and Tissue-based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin. Angew. Chem. Int. Ed.2018,57, 9284 –9289. Cheng, K.; Lee, J. S.; Hao, P.; Yao, S. Q.; Ding, K.;*Li, Z.*Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.Angew. Chem. Int. Ed.2017, 56，15044-15048. Fan, Y.; Si, H.; Zhang, Z.; Zhong, L.; Sun, H.; Zhu, C.; Yin, Z.;Li, H.; Tang, G.; Yao, Shao Q.; Sun, P.;* Zhang, Z.-M.;* Ding, K.;* Li, Z.* Novel Electrophilic Warhead Targeting a Triple-Negative BreastCancer Driver in Live Cells Revealed by “Inverse Drug Discovery”.J. Med. Chem. 2021. Li, Z.; Li, L.; Qian, L.; Bernhammer, J. C.; Huynh, H. V.; Lee, J. S.;Yao, S. Q.*Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications.Angew. Chem. Int. Ed.2016,55, 2002-2006. Li, Z.;Wang, D.;Li L.;Pan, S.; Na, Z.; Tan, C. Y. J.;Yao, S. Q.*.'Minimalist' Cyclopropene-Containing Photo-Cross-Linkers Suitable for Affinity-Based Protein Labeling and Live-Cell Imaging. J. Am. Chem. Soc. 2014, 136, 9990-9998. Li, Z.; Hao, P.; Li, L.; Tan, C. Y. J.; Cheng, X.; Chen, G. Y. J.; Sze, S. K.; Shen, H.-M.; Yao, S. Q.*. Design and Synthesis of “Minimalist”Terminal Alkyne-Containing Diazirine Photo-Cross-Linkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling. Angew. Chem. Int. Ed.2013, 52, 8551-8556.