訾佳辰 - 暨南大学

个人简介

2001年和2004年在沈阳药科大学分别获得中药学专业学士学位和生药学专业硕士学位；2008年中国医学科学院&北京协和医学院药物研究所获得天然产物化学专业博士学位；之后分别在美国伊利诺伊大学、犹他州立大学和爱荷华州立大学从事天然产物相关领域的博士后研究。2015年起在暨南大学药学院任职，从事中药学和天然产物领域的教学科研工作。

研究领域

1. 中药及天然药物活性成分的发现；2. 中药及天然药物活性成分的生物合成；3. 代谢工程学；4. 酶催化机制；5. 生物信息学

近期论文

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1. Jiachen Zi, Yuki Matsuba, Young J. Hong, Alana J. Jackson, Dean J. Tantillo, Eran Pichersky and Reuben J. Peters. Biosynthesis of lycosantalonol, a cis-prenyl derived diterpenoid. J. Am. Chem. Soc., 2014, 136: 16951-16953. (IF=12.113) 2. Jiachen Zi, Sibongile Mafu, and Reuben J. Peters. To Gibberellins and Beyond! Surveying the Evolution of (Di)terpenoid Metabolism. Annu. Rev. Plant Biol., 2014, 65, 259-286 (IF=23.3) 3. Alexander Boutanaev, Tessa Moses, Jiachen Zi, David Nelson, Sam Mugford, Reuben J. Peters and Anne Osbourn. Investigation of terpene diversification across multiple sequenced plant genomes. Proc. Natl. Acad. Sci., 2015, 112: E81-88. (IF=9.674) 4. Kevin Potter, Jared Criswell, Jiachen Zi and Reuben J. Peters. Novel product chemistry from mechanistic analysis of ent-copalyl diphosphate synthases from plant hormone biosynthesis. Angew. Chem. Int. Ed., 2014, 53, 7198-7202. (IF=11.261) 5. Dayu Yu, Fuchao Xu, Jiachen Zi, Siyuan Wang, David Gage, Jia Zeng, Jixun Zhan. Engineered production of fungal anticancer cyclooligomer depsipeptides in Saccharomyces cerevisiae. Metab. Eng., 2013, 18, 60-68. (IF=6.859) 6. Jiachen Zi, Daniel Lantvit, Steven M. Swanson, Jimmy Orjala. Lyngbyaureidamides A and B, Two Anabaenopeptins from the Cultured Freshwater Cyanobacterium Lyngbya sp. Phytochemistry. 2012, 74, 173-177. (IF=3.351) 7. Jiachen Zi, Shuai Li, Mingtao Liu, Maoluo Gan, Sheng Lin, Weixia Song, Yanling Zhang, Xiaona, Fan, Yongchun Yang, Jianjun Zhang, Jiangong Shi, Duolong Di. Glycosidic Constituents of the tubers of Gymnadenia conopsea., J. Nat. Prod. , 2008, 71, 799-805. (IF=3.285) 8. Yuki Matsuba1, Jiachen Zi, A. Daniel Jones, Reuben J. Peters, Eran Pichersky. Biosynthesis of the Diterpenoid Lycosantalonol via Nerylneryl Diphosphate in Solanum lycopersicum. Plos one, 2015, 10:e0119302. (IF=3.234) 9. Adam T. Klein, Gargey B. Yagnik, Jessica D. Hohenstein, Zhiyuan Ji, Jiachen Zi, Malinda D. Reichert, Gustavo C. MacIntosh, Bing Yang, Reuben J. Peters, Javier Vela, Young Jin Lee. Investigation of the Chemical Interface in the Soybean−Aphid and Rice−Bacteria Interactions Using MALDI-Mass Spectrometry Imaging. Anal. Chem. 2015, 87, 5294−5301. (IF=5.636) 10. David M. Hershey, Xuan Lu, Jiachen Zi and Reuben J. Peters. Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia. J. Bacteriol., 2014, 196, 100-106. (IF=3.825) 11. Jiachen Zi and Reuben J. Peters. Characterization of CYP76AH4 clarifies plant phenolic diterpenoid biosynthesis. Org. Biomol. Chem., 2013, 11, 7650-7652. (IF=3.568) 12. Jiachen Zi, S. Gabrielle Gladstone, Jixun Zhan. Specific 5-Hydroxylation of Piperlongumine by Beauveria bassiana ATCC 7159. Biosci. Biotechnol. Biochem. 2012, 76(8), 1565-1567. (IF=1.329) 13. Lei Shao, Jiachen Zi, Jia Zeng, Jixun Zhan. Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982. Appl Environ Microbiol. 2012, 78, 2034-2038. (IF=3.829) 14. Mingtao Liu, Sheng Lin, Maoluo Gan, Minghua Chen, Li Li, Sujuan Wang, Jiachen Zi, Xiaona Fan, Ying Liu, Yikang Si, YongchunYang, Xiaoguang Chen, and Jiangong Shi. Yaoshanenolides A and B: New Spirolactones from the Bark of Machilus yaoshansis. Org. Lett., 2012, 14, 1004-1007. (IF=6.142) 15. Maoluo Gan, Mingtao Liu, Bo Liu, Sheng Lin, Yanling Zhang, Jiachen Zi, Weixia Song, Fei Ye, Xiaoguang Chen, Jiangong Shi. Cucurbitane Glucosides from the Root of Machilus yaoshansis. J. Nat. Prod. , 2011, 74, 2431-2437. (IF=3.285) 16. Jiachen Zi, Jonathan Valiente, Jia Zeng, Jixun Zhan. Metabolism of Quercetin by Cunninghamella elegans ATCC 9245. J. Biosci. Bioeng. 2011, 112, 360-362. (IF=1.793) 17. Mingtao Liu, Maoluo Gan, Sheng Lin, Yanling Zhang, Jiachen Zi, Weixia Song, Xiaona Fan, Ying Liu, Yongchun Yang, and Jiangong Shi. Machilusides A and B: Structurally Unprecedented Homocucurbitane Glycosides from the Stem Bark of Machilus yaoshansis. Org. Lett., 2011, 13, 2856-2859. (IF=6.142) 18. Sheng Lin, Yanling Zhang, Mingtao Liu, Sen Yang, Maoluo Gan, Jiachen Zi, Weixia Song, Xiaona Fan, Sujuan Wang, Yang Liu, Yongchun Yang, Xiaoguang Chen, Yin Guo, Wenjie Wang, Jiangong Shi. Abietane and C20-Norabietane Diterpenes from the Stem Bark of Fraxinus sieboldiana and Their Biological Activities. J. Nat. Prod., 2010, 73, 1914-1921. (IF=3.285) 19. Pengfei Zhou, Jiazeng Yang, Jianhua Zhu, Shuijie He, Wenjin Zhang, Rongmin Yu, Jiachen Zi, Liyan Song, Xuesong Huang. Effects of β-cyclodextrin and methyl jasmonate on the production of vindoline, catharanthine, and ajmalicine in Catharanthus roseus cambial meristematic cell cultures. Appl. Microbiol. Biotechnol. (online DOI10.1007/s00253-015-6651-9). (IF=3.337). 20. Xiaona Fan, Jiachen Zi, Chenggen Zhu, Wendong Xu, Wei Cheng, Sen Yang, Ying Guo, Jiangong Shi. Chemical Constituent of Heteroplexis micocephala. J. Nat. Prod., 2009, 72, 1184-1190. (IF=3.285)