张冬梅 - 暨南大学

个人简介

2000年毕业于中国药科大学，获学士学位。2003年毕业于中国药科大学药物化学专业，获硕士学位。2007年毕业于香港中文大学生物化学系，获博士学位。2008年初进入暨南大学药学院工作。

研究领域

主要从事天然抗肿瘤活性成分的筛选、作用靶点和作用机制研究以及创新药物的研究开发。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang DM, Xu HG, Wang L, Li YJ, Sun PH, Wu XM, Wang GJ, Chen WM, Ye WC. Betulinic Acid and its Derivatives as Potential Antitumor Agents. Med Res Rev, 2015, 35:1127-55. Deng LJ, Peng QL, Wang LH, Xu J, Liu JS, Li YJ, Zhuo ZJ, Bai LL, HuLP, Chen WM, Ye WC*, Zhang DM*. Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway. Oncotarget, 2015, 6:34258-75. Zhang DM, Liu JS, Tang MK, Yiu A, Cao H, Jiang L, Chan YW, Tian HY, Fung KP, Pan JX, Ye WC. Arenobufagin-induced apoptosis and autophagy in Hepatoma carcinoma cells though PI3K/Akt/mTOR pathway. Carcinogenesis, 2013, 34:1331-42. Liu JS$, Zhang DM$, Li Y, Chen WM, Ruan ZX, Deng LJ, Wang LW, Tian HY, Yiu A, Fan CL, Luo HB, Liu SW, Wang Y, Xiao GK, Chen LX, Ye WC. Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities. Journal of Medicinal Chemistry, 2013, 56:5734-43. ($共第一作者) Zhuo ZJ, Hu JJ, Yang XL, Chen MF, Lei XP, Deng LJ, Yao N, Peng QL, Chen ZS, Ye WC*, Zhang DM*. Ailanthone inhibits Huh7 cancer cell growth via cell cycle arrest and apoptosis in vitro and in vivo. Scientific Reports, 2015, 5:16185. Shi JM, Bai LL, Zhang DM*, Yiu, A, Yin ZQ, Han WL, Liu JS, Li Y, Fu DY, Ye WC*. Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress. Biochemical Pharmacology, 2013, 85:913-26. Xiang QF$, Zhang DM$, Wang JN, Zhang HW, Zheng ZY, Yu DC, Li YJ, Xu J, Chen YJ, Shang CZ. Cabozantinib reverses multidrug resistance of human hepatoma HepG2/adr cells by modulating the function of P-glycoprotein. Liver Int. 2015, 35:1010-23. ($共第一作者) Zhang DM, Shu C, Chen JJ, Sodani K, Wang J, Bhatnagar J, Lan P, Ruan ZX, Xiao ZJ, Ambudkar SV, Chen WM, Chen ZS, Ye WC. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Molecular Pharmaceutics, 2012, 9:3147-59. Lei XP, Chen MF, Nie QL, Hu JY, Zhuo ZJ, Yiu A, Chen HR, Xu NH, Huang MH, Ye KH, Bai LL, Ye WC, Zhang DM*. In vitro and in vivoantiangiogenic activity of desacetylvinblastine monohydrazide through inhibition of VEGFR2 and Axl pathways. Am J Cancer Res. 2016, 6: 1-16. Yang XL, Wang RF, Zhang SP, Zhu WJ, Tang J, Liu JF, Chen P*, Zhang DM*, Ye WC, Zheng YL. Polysaccharides from Panax japonicus C.A. Meyer and their antioxidant activities. Carbohyd Polym. 2014,101:386-391.