于沛 - 暨南大学

个人简介

1988和1991年于武汉大学分别获学士和分析化学硕士；1997年香港中文大学获合成化学博士；后赴英国诺丁汉大学从事博士后研究。2000年归国先后任国内著名大型医药企业技术中心副主任兼研究所所长等职。2007年调入暨南大学药学院任职药物化学的教学和科研工作。

研究领域

化学药物的设计、合成与工艺优化；通过对中药有效成份分子结构进行系统的化学修饰，筛选活性，进行新药创制和研发。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Li, S.; Shan, L.; Zhang, Z.; Li, W.; Liao, K.; Sheng, X.; Yu, P.; Wang, Y., Pharmacokinetic and Metabolic Studies of ADTM: A Novel Danshensu Derivative Confers Cardioprotection by HPLC-UV and LC-MS/MS. J Chromatogr Sci 2015, 53, 872-8. (通讯作者) 2. Sun, Y. W.; Tan, Z. C.; Liang, Z. B.; Wang, L.; Shan, L. C.; Yu, P.; Lee, S. M.; Wang, Y. Q., Synthesis and relationship of stability and biological activity of new DSS and TMP conjugates. Medchemcomm 2015, 6, 586-591. (通讯作者) 3. Fu, P.; Li, Z.; Wang, Y.; Yu，P. Synthesis of 3-(5H-Pyrazolyl)cyclobutanone Derivative. Asian. J. of Chem. 2015, 27(7), 2545-2547. (通讯作者) 4. Lang, M.; Yao, H.; Fu, P.; Cai, W.; Wang, Y.; Yu, P., An unexpected replacement of a methyl with an amino in the tetramethylpyrazine system. Research on Chemical Intermediates 2014. (通讯作者) 5. Sun, Y. W.; Liao, K. Y.; Li, S.; Zhang, Z. J.; Yu, P.; Wang, Y. Q., Pharmacokinetic Analysis of Tetramethylpyrazine Bis-Nitrone TN-2 in Rats and its Protein Binding In Vitro. Letters in Drug Design & Discovery 2014, 11, 770-777. (通讯作者) 6. Xu, L. P.; Li, Y. M.; Wan, S. N.; Wang, Y. Q.; Yu, P., Protective effects of apocynin nitrone on acute lung injury induced by lipopolysaccharide in rats. International Immunopharmacology 2014, 20, 377-382. (通讯作者) 7. Liang, Z. B.; Du, E. M.; Xu, L. P.; Sun, Y. W.; Zhang, G. X.; Yu, P.; Wang, Y. Q., Synthesis and Preliminary Biologic Activity Evaluation of Nitric Oxide-Releasing Andrographolide Derivatives in RIN-m Cells. Chemical & Pharmaceutical Bulletin 2014, 62, 519-523. (通讯作者) 8. Wu, H.; Li, W.; Sun, Y.; Xu, L.; Yu, P.; Wang, Y.; Zhang, Z. Determination of AL-1 in rat plasma and tissues by high-performance liquid chromatography and tts application in AL-1 pharmacokinetic study. J. Pharm. Biomed. Sci., 2014, 4, 573–580. 9. Zhang, Z.; Lai, D.; Wang, L.; Yu, P.; Zhu, L.; Guo, B.; Xu, L.; Zhou, L.; Sun, Y.; Lee, S. M.; Wang, Y. Neuroprotective effects of the andrographolide analogue AL-1 in the MPP(+)/MPTP-induced Parkinson's disease model in vitro and in mice. Pharmacol Biochem Behav 2014, 122, 191-202. 10. Cui, Q.; Chen, Y.; Zhang, M.; Shan, L.; Sun, Y.; Yu, P.; Zhang, G.; Wang, D.; Zhao, Z.; Xu, Q.; Xu, B.; Wang, Y. Design, synthesis and preliminary cardioprotective effect evaluation of Danshensu derivatives. Chem Biol Drug Des 2014, 84, 282-291