王玉强 - 暨南大学

个人简介

1981年毕业于山东师范大学化学系, 获学士学位；1987年获美国 University of Texas Health Science Center at Houston and M. D. Anderson Cancer Center博士学位。随后进入美国耶鲁大学 (Yale) 医学院做博士后研究。九十年代初进入美国加州硅谷的生物医药公司从事药物的研究与开发，2005年回国任暨南大学教授，药学院院长，现任暨南大学新药研究所所长，博士生导师。2010年获广州经济技术开发区科技领军人才称号。

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1. Farquhar, D.; Wang, Y. Novel antitumor organophosphates. The Cancer Bulletin Vol. 37, No.4. 167, 1985. 2. Beran, M.; Andersson, B. S.; Wang, Y.; McCredie, K. B.; Farquhar, D. The effects of acetalaldophosphamide, a novel stable aldophosphamide analogue, on normal human and leukemic progenitor cells in vitro: Implications for use in bone marrow purging. Cancer Res. 48, 339, 1988. 3. Andersson, B. S.; Wang, Y.; Farquhar, D. Stable in vitro active aldophosphamide acetals for bone marrow purging. Autologous Bone Marrow Transplantation, in proceedings of the fourth international symposium. 1989. 4.Andersson, B. S.; Wang, Y.; McCredie, K. B.; Farquhar, D. Suitability of a new stable acetal analogue of aldoifosphamide for purging leukemic cells from human bone marrow. Leukemia 6, 435, 1990. 5. Wang, Y.; Farquhar, D. Aldophosphamide acetal diacetate and structural analogues: synthesis and cytotoxicity studies. J. Med. Chem. 34, 197, 1991. 6. Wang, Y.; Liu, M. C.; Lin, T. S.; Sartorelli, A. C. Synthesis and biological evaluation of novel antitumor 3- and 5-hydroxy-4-methyl-2-formylpyridine thiosemicarbazones and their iron-chelates. J. Med. Chem. 35, 3667, 1992. 7. Wang, Y.; Lown, J. L. An alternative method for synthesis of the CC-1065 pharmacophore, 1,2,7,7a-tetrahydrocyclopropa[1,2-c]indol-4-one (CI). Heterocycles 36, 1399, 1993. 8. Wang, Y.; Gupta, R.; Huang, L.; Lown, J. W. Synthesis and antitumor activity of CC-1065 functional analogues possessing different electron-withdrawing substituents and leaving groups. J. Med. Chem. 36, 4172, 1993. 9. Wang, Y.; Huang, L.; Wright, S. C.; Larrick, J. W. Synthesis and antitumor activity studies of doxorubicin and DNA-minor groove binding oligopeptide conjugates. Gene 149, 63, 1994. 10. Fregeau, N. L.; Wang, Y.; Pon, R, T.; Wylie, W. A.; Lown, J. W. Characterization of a CPI-Lexitropsin Conjugate: Oligonucleotide covalent complex by 1H NMR and restrained molecular dynamics simulation. J. Amer. Chem. Soc. 117, 8917, 1995. 11. Wang, Y.; Gupta, R.; Huang, L.; Luo, W.; Lown, J. W. Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI-N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency. Anti-Cancer Drug Design 11, 15, 1996. 12. Wright, S. C.; Schellenberger, U.; Wang, H.; Wang, Y.; Kinder, D. H. Chemotherapeutic drug activation of the AP24 protease in apoptosis: Requirement for caspase 3-like proteases. Biochem. Biophys. Res. Commun. 245, 797, 1998. 13. Wang, Y.; Yuan, H.; Ye, W.; Wang, H.; Wright, S. C.; Larrick, J. W. Synthesis and preliminary biological evaluations of CC-1065 analogs: effects of different linkers and terminal amides on biological activity. J. Med. Chem. 43, 1541. 2000. 14. Wang, Y.; Yuan, H.; Wright, S. C.; Wang, H.; Larrick, J. W. Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue. BMC Chemical Biology 1, 4, 2001. 15. Wang, Y.; Yuan, H.; Wright, S. C.; Wang, H.; Larrick, J. W. Synthesis and cytotoxicity of a biotinylated CC-1065 analogue. BMC Chemical Biology 2, 1. 2002. 16. Wang, Y.; Wright, S. C.; Larrick, J. W. Synthesis and cytotoxicity of nitrogen mustard derivatives of distamycin A. Bioorg. Med. Chem. Lett. 13, 461, 2003. 17. Wang, Y.; Ye, W.; Li, L.; Tian, Z.; Jiang, W.; Wang, H.; Wright, S. C.; Larrick, J. W. CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity and preliminary toxicity study. J. Med. Chem. 46, 634, 2003. 18. Wang, Y.; Yuan, H.; Wang, H.; Wright, S. C.; Larrick, J. W. Synthesis and preliminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues. Bioorg. Med. Chem. 11, 1569, 2003. 19. Wang, X.; Wang, Y.; Zheng, C. Isolation and purification of honokiol and magnolol from Cortex Magnoliae Officinalis by high-speed counter-current chromatography. J. Chromatography A., 1036, 171, 2004. 20. Wang, X.; Wang, Y.; Yuan, J.; Sun, Q.; Liu, J.; Zheng, C. An efficient new method for extraction, separation and purification of psoralen and isopsoralen from Fructus Psoraleae by supercritical fluid extraction and high-speed counter-current chromatography. J. Chromatography A, 1055, 135, 2004.