个人简介
王英,理学博士,暨南大学教授、博士生导师,广东省中药药效物质基础与创新药物研究重点实验室副主任。国家优秀青年基金获得者、教育部新世纪人才。1999年毕业于中国药科大学中药学院中药制剂专业,2003、2006年分别在同校获药物化学专业硕士和博士学位。攻读博士学位期间,于2004年2月至2006年4月间,赴香港科技大学生物化学系进行联合培养。2006年起,进入暨南大学药学院工作,先后任博士后、副教授、教授职位。
一直围绕中药及天然药物的活性成分开展研究工作。近年来,已先后对一叶萩、番石榴等40余种中药及天然药物开展了比较系统的活性成分研究。共分离鉴定了1500余个天然产物,其中新化合物800余个(包括具新颖骨架结构的天然产物30余类),并发现了多个具抗病毒、降血糖及治疗神经系统疾病等活性的天然产物。已在Angew Chem Int Ed、Org Lett、J NatProd、Chem Eur J、J Org Chem等天然药物化学领域国际权威期刊发表SCI收录论文145篇;作为项目负责人主持国家自然科学基金优秀青年基金、“十三五”国家重大新药创制专项、国家自然科学基金面上及青年基金项目、广东省自然科学基金等科研和人才基金项目多项;已申请中国发明专利33项(获授权23项)、PCT专利2项;获国家科学技术进步奖二等奖1项、广东省科学技术奖一等奖3项。
研究领域
(1)中药及天然药物活性成分研究
(2)天然产物来源的创新药物发现研究
近期论文
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He QF, Wu ZL, Li L, Sun WY, Wang GY, Jiang RW, Hu LJ, Shi L, He RR, Wang Y*, Ye WC*. Discovery of Neuritogenic Securinega Alkaloids from Flueggeasuffruticosa by a Building Blocks-Based Molecular Network Strategy, Angewandte Chemie International Edition, 2021, 60: 19609–19613.
Wu ZL, Zhao BX, Huang XJ, Tang GY, Shi L, Jiang RW, Liu X, Wang Y*, Ye WC*. Suffrutines A and B: A pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa, Angewandte Chemie International Edition, 2014, 53: 5796–5799.
Deng LM, Hu LJ, Bai YTZ, Wang J, Qin GQ, Song QY, Su JC, Huang XJ, Jiang RW, Tang W, Li YL, Li CC*, Ye WC*, Wang Y*. Rhodomentosones A and B: Two Pairs of Enantiomeric Phloroglucinol Trimers from Rhodomyrtus tomentosa and Their Asymmetric Biomimetic Synthesis, Organic Letters, 2021, 23: 4499–4504.
Deng LM, Hu LJ, Tang W, Liu JX, Huang XJ, Li YY, Li YL, Ye WC*, Wang Y*. A biomimetic synthesis-enabled stereochemical assignment of rhodotomentones A and B, two unusual caryophyllene-derived meroterpenoids from Rhodomyrtus tomentosa, Organic Chemistry Frontiers, 2021, 8: 5728–5735.
He QF, Wu ZL, Huang XJ, Xia TQ, Tang G, Tang W, Shi L, Ye WC*, Wang Y*. Cajanusoids A–D, Unusual Atropisomeric Stilbene Dimers with PTP1B Inhibitory Activities from the Leaves of Cajanus cajan, The Journal of Organic Chemistry, 2021, 86: 5870–5882.
Yang WQ, Shao XH, Deng F, Hu LJ, Xiong Y, Huang XJ, Fan CL, Jiang RW, Ye WC*, Wang Y*. Unprecedented Quassinoids from Eurycoma longifolia: Biogenetic Evidence and Antifeedant Effects, Journal of Natural Products, 2020, 83: 1674–1683.
Song JG, Su JC, Song QY, Huang RL, Tang W, Hu LJ, Huang XJ, Jiang RW, Li YL, Ye WC*, Wang Y*. Cleistocaltones A and B, Antiviral Phloroglucinol-Terpenoid Adducts from Cleistocalyx operculatus, Organic Letters, 2019, 21: 9579–9583.
Wu ZL, Huang XJ, Xu MT, Ma X, Li L, Shi L, Wang WJ, Jiang RW, Ye WC*, Wang Y*. Flueggeacosines A–C, Dimeric Securinine-Type Alkaloid Analogues with Neuronal Differentiation Activity from Flueggea suffruticosa, Organic Letters, 2018, 20: 7703–7707.
Su JC, Cheng W, Song JG, Zhong YL, Huang XJ, Jiang RW, Li YL, Li MM*, Ye WC*, Wang Y*. Macrocyclic Diterpenoids from Euphorbia helioscopia and Their Potential Anti-inflammatory Activity, Journal of Natural Products, 2019, 82: 2818–2827.
He QF, Wu ZL, Huang XJ, Zhong YL, Li MM, Jiang RW, Li YL, Ye WC*, Wang Y*. Cajanusflavanols A–C, Three Pairs of Flavonostilbene Enantiomers from Cajanus cajan, Organic Letters, 2018, 20: 876–879.