陈河如 - 暨南大学

个人简介

1989年6月毕业于中山大学化学系，获理学学士学位及优秀毕业生称号, 1992年9月考取中国科学院上海有机化学研究所硕士研究生，1995年6月毕业并获理学硕士学位。1999年5月赴香港大学化学系进行合作研究，任助理研究员。2000年1月考取香港科技大学化学系博士研究生，于2002年11月毕业并获哲学（化学）博士学位；同年赴加拿大蒙特利尔临床研究院（Clinical Research Institute of Montreal，Canada）进行合作研究，任博士后研究员。2007年2月赴德国Wuppertal大学访问，2008年2月回国。 1989.7-2008.2期间，曾断续在汕头大学工作，历任助教、讲师、副教授、汕头大学多学科研究中心顾问等职。2008年3月至今，任暨南大学药学院药物化学教授, 博士生导师。

研究领域

天然产物的结构修饰及全合成、新药设计/合成/作用机理研究、合成工艺研究

近期论文

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Wang, R., Yang, J., Peng, L., Zhao, J., Mu, N., Huang, J., Lazarovici, P., Chen, H.*, and Zheng, W.* Gardenamide A attenuated cell apoptosis induced by serum deprivation via ERK1/2 and PI3K/Akt signaling pathways. Neuroscience 2015, 286, 242-250. (IF3.3) Jiaqiang Zhao, Lizhi Peng , Rikang Wang , Lei Zhang, Xinyi Zhang, Jian Yang, Wenhua Zheng*, Heru Chen*. Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects Against Corticosterone-Induced Insults in PC12 Cells. Int. J. Mol. Sci. 2015, (IF2.8) Rikang Wang, Lizhi Peng, Jiaqiang Zhao, Laitao Zhang, Cuiping Guo, Wenhua Zheng*, Heru Chen*. Gardenamide A Protects RGC-5 Cells from H2O2-induced Oxidative Stress Insults by Activating PI3K/Akt/eNOS Signaling Pathway. Int. J. Mol. Sci. 2015, (IF2.8) Fu-xiang Jiang, Qiao-zhen Liu, Dan Zhao, Cui-ting Luo, Cui-ping Guo, Wen-cai Ye, Cheng Luo, Heru Chen*. A concise synthesis of N-substituted fagomine derivatives and the systematic exploration of their a-glycosidase inhibition. Eur J Med Chem 2014, 77, 211-222. （IF 3.5） Jing Zheng, Lijuan Deng, Minfeng Chen, Xuzhi Xiao, Shengwei Xiao, Cuiping Guo, Gaokeng Xiao, Liangliang Bai, Wencai Ye, Dongmei Zhang*, Heru Chen*. Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity. Eur J Med Chem, 2013, 65, 158-167 （IF 3.5） Wang, R., Yang, J., Zhang, L., Xiao, G., Luo, J., Liao, S., Chen, H.*, and Zheng W.* Stereoselective Reduction of 1-O-Isopropyloxygenipin Enhances Its Neuroprotective Activity against Apoptosis in PC12 Cells Induced by Sodium Nitroprusside. ChemMedChem 2014, 9(7), 1397-1401. （IF 3.15） Huan-huan Zheng, Cui-ting Luo, Heru Chen*, Juan-na Lin, Chun-lin Ye, Shuang-shuang Mao, Yu-lin Li. Xanthones from Swertia mussotii as multi-target-directed anti-diabetic agents. ChemMedChem 2014, 9(7), 1378-1386.. (IF 3.15) Luo, J., Wang, R. –K., Huang, Z., Yang, J., Yao, X. –S., Chen, H. R.*, Zhen, W. –H.* Synthesis of Stable Derivatives from Genipin and Studies of Their Neuroprotective Activity in PC12 Cells. ChemMedChem 2012, 7(9), 1661-1668（IF 3.15） Cui-ting Luo, Huan-huan Zhen, Shuang-shuang Mao, Mao-xun Yang, Cheng Luo, Heru Chen*. Xanthones from Swertia mussotii and their a-glycosidase inhibitory activities. Planta Medica 2014, 80, 201-208 (IF 2.23) Cui-ting Luo, Shuang-shuang Mao, Fang-lan Liu, Mao-xun Yang, Hiroshi Kurihara, Yulin Li, Heru Chen*. Antioxidant Xanthones from Swertia mussotii, a High Altitude Plant. Fitoterapia 2013, 91, 140-147 (IF 2.15) Cui-ping Guo, Long Pan, Shengwei Xiao, Heru Chen* and Zhenyou Jiang. Short Simple Linear Peptides Mimic Antimicrobial Complex Cyclodecapeptides Based on the Putative Pharmacophore. Med Chem 2014, 4(1), 322-329. (IF 1.37) Yuanyuan Deng, Peipei Gao, Cuiping Guo, Long Wu, Jun Xu, Heru Chen*, and Shaohui Cai*. Z-GP Modification to CI-994, a Histone Deacetylase Inhibitor and the Application in Targeting Carcinoma Chemotherapy. Med. Chem. 2013, 3(2), 199-205. Xiao, X. –Z., Chen, P., Chen, H. –R*. 6-(N, N-dimethylamino)-2-Naphthoylacryl acid: A Highly Selective and Sensitive Fluorescent Sensor of Copper (II). Chem Res in Chin Uni, 2012, 28(4), 608-613. (IF 0.86) Chen, H., Scherkenbeck, J.*, Zdobinsky T., Antonicek, H. Fluorescent Analogues of the Insect Neuropeptide Helicokinin I: Synthesis, Photophysical Characterization and Biological Activity. Protein & Peptide Letters 2010, 17(4), 416-418. Chen HeRu*, Yang Yang, Weng JiangDuo. Aladan Scan: The Structure-Activity relationship of dynorphin A. Science in China Series B 2009, 52(3), 338-343.