山长亮 - 暨南大学 - 生物医学转化研究院

个人简介

学习经历 2006-2011 南开大学生命科学学院生物化学与分子生物学理学博士 2001-2006 鲁东大学生命科学学院生物技术理学学士工作经历 2015至今暨南大学生物医学转化研究院研究员 2011-2015 埃默里大学医学院博士后

研究领域

1. 代谢酶的翻译后修饰（乙酰化，磷酸化和甲基化等）在肿瘤代谢中的作用及其机制； 2. 上皮间充质转化（epithelial- mesenchymal transition,EMT）过程中代谢的变化及作用机制； 3. 肿瘤细胞耐药重组细胞代谢的作用及分子机制研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Lin, R*., Elf, S*., Shan, C*., Kang, H.-B., Ji, Q., Zhou, L., Hitosugi, T., Zhang, L.,Seo, J.H., Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., DeBerardinis R.J.,Wu, S., Li, Y., Mao, H., Chen, P., Lonial, S., Arellano, M., Khoury, H.J.,Khuri, F.R., Lee, B.H., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S.,Fan, J. , and Chen, J.(2015)6-phosphogluconate dehydrogenase linksoxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling. NatureCell Biology DOI: 10.1038/ncb3255 * 共同一作(影响因子=19.679) 2. Wang,J*., Luo, C*.,Shan, C*., You, Q*., Elf, S., Lu, Y., Zhou, Y., Wen, Y., Vinkenborg, J.L., Fan, J., Kang,H., Han, D., Karpus, J., Xie, Y., Ouyang, S., Luan, C., Zhang, N., Merkx, M.,Liu, H., Chen, J., Jiang, H., He, C. (2015) Inhibition of humancopper trafficking significantly attenuates tumor growth. NatureChemistry DOI:10.1038/nchem.2381 * 共同一作(影响因子=25.325) 3. Kang, H.-B., Fan, J., Lin, R.,Elf, S., Ji, Q., Zhao, L., Jin, L., Seo, J.-H., Shan, C., Arbiser, J., Cohen, C., Brat, D., Miziorko, H., Kim, E., Abdel-Wahab O., Merghoub, T., Fröhling, S., Scholl, C., Tamayo, P., Barbie, D., Zhou, L., Pollack, B., Fisher, K., Kudchadkar, R., Lawson, D., Sica, G.,Ross, M., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., Boggon, T.J., He,C., Kang, S., and Chen, J (2015)Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway toBRAF-MEK1 Signaling. Molecular Cell. 2015.05.037. (影响因子=14.61) 4. Shan, C*., Elf, S*., Ji, Q., Kang,H.-B., Zhou, L., Hitosugi, T., Zhang, L., Seo, J.H., Xie, J., Tucker, M., Gu,T.-L., Sudderth, J.A., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, P.,Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Brat, D.J., Ye,K., Boggon, T.J., He, C., Kang, S., Fan, J. , and Chen, J.(2014) Lysine acetylation activates 6-phosphogluconatedehydrogenase to promote tumor growth. Molecular Cell 55(4):552-65 * 共同一作(影响因子=14.61) 5. Fan, J*., Shan, C*.,Kang, H.-B*., Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S.,Chen, H., Mohannadi, M., Britton, L-M P., Garcia, BA. Aleckovic, M., Kang, Y.,Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, JH., Lonial, S., Gaddh, M.,Arellano, M., Khoury, HJ., Khuri, FR., Boggon, TJ., Kang, S., and Chen, J.(2013) Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvatedehydrogenase complex. Molecular Cell 53(4):534-48.*共同一作(影响因子=14.61) 6. Shan, C., Kang, H.-B., Elf, S., Xie,J., Gu, T.-L., Aguiar Mike, Scott Lonning, Hitosugi, T., Chung T,-W, Martha Arellano , Khoury, H.J., Khuri, F.R., Shin, D.M.,Boggon, T. and Fan,J. (2014) Tyr-94 Phosphorylation Inhibits PyruvateDehydrogenase Phosphatase 1 and Promotes Tumor Growth. J. Biol. Chem289(31):21413-22.(影响因子=4.6) 7. Shan, C., Zhang, S., Cui, W., You, X., Kong, G., Du, Y., Qiu, L., Ye,L., Zhang, X. (2011) Hepatitis B virus X protein activates CD59involving DNA binding and let-7i in protection of hepatoma and hepatic cellsfrom complement attack. Carcinogenesis 32(8):1190-7.(影响因子=5.266) 8. Shan, C., Xu, F. Zhang, S., You, J., You, X., Qiu, L., Zheng, J., Ye, L., Zhang, X. (2010). Hepatitis B virus X protein promotes livercell proliferation via a positive cascade loop involving arachidonic acidmetabolism and p-ERK1/2.Cell Res20(5):563-75. (影响因子=11.981) 9. Zhang,S*., Shan, C*., Cui, W., You, X., Du,Y., Kong, G., Gao, F., Ye, L., Zhang, X. (2013) Sumoylation ofnucleophosmin/B23 regulates its subcellular localization, mediating cellproliferation and survival. FEBSLett 587(6):645-51. *共同一作(影响因子=3.470) 10. Zhang, S., Shan,C.,Kong, G., Du, Y., Ye, L., Zhang, X. (2012) MicroRNA-520e suppresses growth ofhepatoma cells by targeting the NF-κB-inducing kinase (NIK). Oncogene 31(31):3607-20. (影响因子=8.559) 11. Zhang, T., Zhang, J., You, X., Liu, Q., Du,Y., Gao, Y., Shan, C., Kong G., Wang,Y., Yang, X., Ye, L., Zhang, X. (2012) FGFR3 activates RSK2 to mediatehematopoietic transformation through both tyrosine phosphorylationof RSK2 and activation of the MEK/ERK pathway. Hepatology 56(6):2051-9.(影响因子=11.19) 12. Hitosugi, T., Zhou, L., Elf,S., Fan, J., Kang, H.-B, Seo, JH., Shan,C., Dai, Q., Zhang, L., Xie, J., Gu, T.-L., Jin, P., Aleckovic, M., LeRoy,G., Kang, Y., Sudderth, JA., DeBerardinis, R.J, Luan, C., Chen, GZ., Muller,SM., Shin, DM., Owonikok,o TK., Lonial, S., Arellano, M., Khoury, HJ., Khuri,FR., Lee, BH., Ye, K., Boggon, TJ., Kang, S., He, C., and Chen, J.(2012) Phosphoglycerate mutase 1 coordinatesglycolysis and biosynthesis to promote tumor growth. Cancer Cell 22(5): 585-600. (影响因子=23.893) 13. Hitosugi, T., Zhou, L., Fan,J., Elf, S., Zhang, L., Xie, J., Wang, Y., Gu, T.-L., Aleckovic, M., LeRoy, G.,Kang, Y., Kang, H.-B., Seo, JH., Shan,C., Jin, P., Gong, W., Lonial, S., Arellano, M., Khoury, HJ., Chen, GZ.,Shin, DM., Khuri, FR., Boggon, TJ., Kang, S., He, C., and Chen, J.(2013) Y26 phosphorylation of PGAM1 provides ametabolic advantage to tumours by stabilizing the active conformation. NatureCommunications 4, Articlenumber:1790; doi:10.1038/ncomms2759(影响因子=10.742)