Davies, Huw - Emory University - Department of Chemistry

个人简介

uw M. L. Davies was born in Aberystwyth, Wales, UK. He received his B. Sc. degree from University College Cardiff, Wales (1977) and his Ph. D degree from the University of East Anglia (1980). After a post-doctoral position at Princeton University (1980-1983), he joined the faculty at Wake Forest University (1883-1995). After being promoted to full professor he moved to the University at Buffalo, the State University of New York (1995-2008) where he held the positions of UB Distinguished Professor and Larkin Professor of Organic Chemistry. In 2008 he moved to Emory University as the Asa Griggs Candler Professor of Chemistry. Professor Davies’ research emphasizes the development of new enantioselective synthetic methods and their applications in total synthesis and drug discovery. A major current theme of his program is catalytic asymmetric C–H functionalization by means of rhodium-carbene induced C–H insertion. He is currently the Director of the NSF Center for Chemical Innovation for Selective C-H Functionalization, which brings together 23 faculty members from 15 universities. Professor Davies is actively involved in the chemical community, having served as the Executive Officer of the 2003 National Organic Symposium, the 2005 Program Chair of the Gordon Conference on Heterocyclic Compounds, the 2005 Chair of the Organic Division of the American Chemical Society, and Co-Organizer of the ACS Organic Division Assistant Professor Symposium at the Fall ACS meeting since 2006. He is an Associate Editor for Chemical Society Reviews and has been as Associate Editor of Organic Reactions (2005-2010) and Organic Syntheses (2008-2016). Recent awards include the American Chemical Society Cope Scholar Award (2005), Fellow of the Royal Society of Chemistry (2007), Fellow of the American Chemical Society (2009), Fellow of the American Association for the Advancement of Science (2012), 2013 eEROS Reagent of the Year Award, Fellow of the National Academy of Inventors (2015), the Alexander von Humboldt Foundation Research Award (2017), the Paul N. Rylander Award (2018) and the ACS Herbert C. Brown Award for Creative Research in Synthetic Methods (2019).

研究领域

Dirhodium(II) stabilized donor/acceptor carbenes display an extensive reactivity profile. A major aspect of our research is to develop these novel transformations and explore their scope and limitations. In particular, asymmetric catalysis has provided an efficient means for the preparation of a wide range of essentially enantiopure compounds. As new and exciting reactivity is discovered within the realm of metal-stabilized carbene chemistry, a greater understanding is sought. Through a number of collaborations we are bringing together both theoretical and experimental approaches to help understand and expand our novel methodologies. The total synthesis of natural products provides the ultimate test for novel methodologies, taking it from a model system and proving its effectiveness in complex systems. The completion of a number of formal and total syntheses have showcased our chemistry and we maintain an active total synthesis program. An integral part of our research program is the application of our asymmetric methodologies to the preparation and exploration of novel pharmaceutical targets. We have established strong collaborations with groups who specialize in a variety of disease states, providing the opportunity to assess the biological activity of the broad range of analogues accessible through our modular approach. The electronic and steric nature of the ligands that surround the dirhodium(II) core have been shown to exert significant influence on the reactivity and selectivity of the catalyst manifold. We have developed generations of remarkable dirhodium(II) catalysts and continue to explore the fundamentals of the dirhodium(II) catalytic system.

近期论文

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Rhodium-Catalyzed Intermolecular C–H Functionalization as a Key Step in the Synthesis of Complex Stereodefined β-Arylpyrrolidines June 21, 2018 Publications Authors: Robert W. Kubiak, II and Huw M. L. Davies Synthesis of [3a,7a]-Dihydroindoles by a Tandem Arene Cyclopropanation/3,5-Sigmatropic Rearrangement Reaction June 11, 2018 Publications Authors: Sidney M. Wilkerson-Hill, Brandon E. Haines, Djamaladdin G. Musaev, and Huw M. L. Davies J. Org. Chem., Article ASAP; DOI: 10.1021/acs.joc.8b00812 Blue light-promoted photolysis of aryldiazoacetates May 22, 2018 Publications Authors: Igor D. Jurberg and Huw M. L. Davies Chem. Sci., 2018, 9, 5112-5118; DOI:10.1039/C8SC01165F Formation of Tertiary Alcohols from the Rhodium-Catalyzed Reactions of Donor/Acceptor Carbenes with Esters April 11, 2018 Publications Liangbing Fu, Kevin Hoang, Cecilia Tortoreto, Wenbin Liu, and Huw M. L. Davies Org. Lett., 2018, 20 (8), pp 2399–2402; DOI: 10.1021/acs.orglett.8b00739 Harnessing the β-Silicon Effect for Regioselective and Stereoselective Rhodium(II)-Catalyzed C–H Functionalization by Donor/Acceptor Carbenes Derived from 1-Sulfonyl-1,2,3-triazoles April 11, 2018 Publications Authors: Zachary J. Garlets and Huw M. L. Davies Org. Lett., 2018, 20 (8), pp 2168–2171; DOI: 10.1021/acs.orglett.8b00427 Site-Selective Carbene-Induced C–H Functionalization Catalyzed by Dirhodium Tetrakis(triarylcyclopropanecarboxylate) Complexes December 18, 2017 Publications Author: Kuangbiao Liao, Wenbin Liu, Zachary L. Niemeyer, Zhi Ren, John Bacsa, Djamaladdin G. Musaev, Matthew S. Sigman, and Huw M. L. Davies ACS Catal. 2018, 8, 678–682 Site-selective and stereoselective functionalization of non-activated tertiary C–H bonds November 30, 2017 Publications Author: Kuangbiao Liao, Thomas C. Pickel, Vyacheslav Boyarskikh, John Bacsa, Djamaladdin G. Musaev & Huw M. L. Davies Nature 2017, 551, 609-613 CEN HIGHLIGHT: Catalyst activates tertiary C–H bonds Press Release: New catalyst controls activation of a carbon-hydrogen bond Collective Approach to Advancing C–H Functionalization September 11, 2017 Publications Author: Huw M. L. Davies and Daniel Morton ACS Cent. Sci. 2017, 3, 936–943 Rhodium- and Non-Metal-Catalyzed Approaches for the Conversion of Isoxazol-5-ones to 2,3-Dihydro-6H-1,3-oxazin-6-ones September 11, 2017 Publications Author: Igor D. Jurberg and Huw M. L. Davies Org. Lett. 2017, 19, 5158–5161. Rh(II)-Catalyzed Cyclopropanation of Furans and Its Application to the Total Synthesis of Natural Product Derivatives August 28, 2017 Publications Author: Verena Lehner, Huw M. L. Davies, and Oliver Reiser Org. Lett. 2017, 19, 4722–4725 Synthesis of Donor/Acceptor-Substituted Diazo Compounds in Flow and Their Application in Enantioselective Dirhodium-Catalyzed Cyclopropanation and C–H Functionalization June 5, 2017 Publications Author: Daniel Rackl, Chun-Jae Yoo, Christopher W. Jones, and Huw M. L. Davies Org. Lett. 2017, 19, 3055–3058 Scope of the Reactions of Indolyl- and Pyrrolyl-Tethered N-Sulfonyl-1,2,3-triazoles: Rhodium(II)-Catalyzed Synthesis of Indole- and Pyrrole-Fused Polycyclic Compounds March 30, 2017 Publications Author: Liangbing Fu, Huw M. L. Davies Org. Lett. 2017, 19, 1504–1507 Synthesis of 2,2,2,-Trichloroethyl Aryl- and Vinyldiazoacetates by Palladium-Catalyzed Cross-Coupling February 15, 2017 Publications Author: Liangbing Fu, Jeffrey D. Mighion, Eric A. Voight, Huw M. L. Davies Chem. Eur. J. 2017, 23,1–5 Metal-Free C–H Functionalization of Alkanes by Aryldiazoacetates February 7, 2017 Publications Author: Cecilia Tortoreto, Daniel Rackl, and Huw M. L. Davies Org. Lett. 2017, 19 (4), pp 770–773 Enantioselective Intermolecular C–H Functionalization of Allylic and Benzylic sp3 C–H Bonds Using N-Sulfonyl-1,2,3-triazoles June 22, 2016 Publications Author: Robert W. Kubiak II, Jeffrey D. Mighion, Sidney M. Wilkerson-Hill, Joshua S. Alford, Tetsushi Yoshidomi, and Huw M. L. Davies Org. Lett. 2016, 18 (13), 3118 Rapid Construction of a Benzo-Fused Indoxamycin Core Enabled by Site-Selective C−H Functionalizations May 20, 2016 Publications Authors: T. Aaron Bedell, Graham A. B. Hone, Damien Valette, Jin-Quan Yu, Huw M. L. Davies, Erik J. Sorensen Angew .Chem. Int. Ed. 2016, 55, 8270 Site-selective and stereoselective functionalization of unactivated C–H bonds May 12, 2016 Publications Authors: Kuangbiao Liao, Solymar Negretti, Djamaladdin G. Musaev, John Bacsa & Huw M. L. Davies Nature 2016, 533, 230–234 Rhodium(II)-Catalyzed C–H Functionalization of Electron-Deficient Methyl Groups April 11, 2016 Publications Authors: Liangbing Fu, David M. Guptill, and Huw M. L. Davies J. Am. Chem. Soc. 2016, 138 (18), pp 5761–5764 Recent Advances in C–H Functionalization January 15, 2016 Publications Authors: Huw M. L. Davies and Daniel Morton J. Org. Chem. 2016, 81 (2), pp 343–350 Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives November 13, 2015 Publications Authors: Tanja Krainz, Sharon Chow, Natasa Korica, Paul V. Bernhardt, Glen M. Boyle, Peter G. Parsons, Huw M. L. Davies, and Craig M. Williams Eur. J. Org. Chem. 2016, 41–44