邵永平 - 西安交通大学 - 前沿科学技术研究院

个人简介

Education 9/2001-5/2007 Ph.D in Molecular Biology, State University of New York at Albany 9/1997-6/2000 M.S. in Botany, Fudan University 9/1993-6/1997 BS in Biology, Fudan University Employment 7 /2013 - Group Leader I , Center for Translational Medicine , Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University, China 12/ 2008-5/2013 Postdoctoral Fellow, Kimmel Cancer Center, Thomas Jefferson University 5/2007-11/ 2008 Postdoctoral Associate, State University of New York at Albany

研究领域

1. Mechanisms of Resistance to targeted therapy in human melanoma. 2. Development of small peptide inhibitors that target the RAS/RAF/MEK/ERK pathway. 3. Development of antibody-based drug delivery methods.

近期论文

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1. Hartsough E, Shao Y, Aplin A.E. 2014. Resistance to RAF Inhibitors Revisited. J Invest Dermatol. 134:319-25. 2. Shao Y. and Aplin A.E. 2012. BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. Cell Death Differ. 19:2029-39. 3. Shao Y. and Aplin A.E. 2012. ERK-regulated phosphorylation of serine 77 regulates Bmf pro-apoptotic activity. Cell Death Dis. 3(1):e253. 4. Aplin A.E., Kaplan F. and Shao Y. 2011. Mechanisms of resistance to B-RAF inhibitors in melanoma. J Invest Dermatol. 131(9):1817-20. 5. Kaplan F. M., Shao Y., Mayberry M.M., Aplin A.E. 2011. Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells. Oncogene. 30(3):366-71 6. Shao Y. and Aplin A.E. 2010. Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res. 15; 70(16):6670-81. 7. Shao Y. and Wang I.N. 2009. Effect of late promoter activity on bacteriophage lambda fitness. Genetics. 181(4):1467-75. 8. Shao Y. and Wang I.N. 2008. Bacteriophage adsorption rate and optimum lysis time. Genetics. 180(1):471-82. 9. Shao Y., Feldman-Cohen L.S. and Osuna R. 2008. Biochemical identification of base and phosphate contacts between Fis and a high affinity DNA binding site. J Mol Biol. 380(2):327-39. 10.Shao Y., Feldman-Cohen L.S. and Osuna R. 2008. Functional characterization of the Escherichia coli Fis-DNA binding sequence. J Mol Biol. 376(3):771-85.