个人简介
EDUCATION
2006-2009 Ph.D in Biomedical Sciences
Aston University, Birmingham, UK
2004-2005 M.Sc in Human Nutrition & Metabolism
University of Aberdeen, Aberdeen, UK
1999-2004 B.M in Preventive Medicine
China Medical University, Shenyang, China
EMPLOYMENT
2014.10- Principal Investigator at the level of Professor, Group Leader III, Center for Mitochondrial Biology and Medicine (CMBM), Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University, China
2012.7-2014.9 Postdoctoral Fellow, Beckman Research Institute of City of Hope, Duarte, California, USA
2009.4-2012.4 Postdoctoral Research Associate, University of Liverpool, Liverpool, UK
研究领域
• Crosstalk between adipose tissue and major metabolic tissues (skeletal muscle, liver and pancreas)
• Nutritional intervention for adipose tissue inflammation and insulin resistance
• Mitochondria and adipose tissue inflammation
近期论文
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1. Gao D, Madi M, Ding C, Fok M, Steele T, Ford C, Hunter L, Bing C.Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E289-304.
2. Gao D, Trayhurn P, Bing C. 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int J Obes (Lond). 2013 Mar;37(3):357-65.
3. Gao D, Pararasa C, Dunston CR, Bailey CJ, Griffiths HR. Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis. Free Radic Biol Med. 2012 Aug 15;53(4):796-806.
4. Gao D, Bing C. Macrophage-induced expression and release of matrix metalloproteinase 1 and 3 by human preadipocytes is mediated by IL-1β via activation of MAPK signaling. J Cell Physiol. 2011 Nov;226(11):2869-80.
5. Gao D, Trayhurn P, Bing C. Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):135-42.
6. Mracek T*, Gao D*, Tzanavari T, Bao Y, Xiao X, Stocker C, Trayhurn P, Bing C. Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytes. J Endocrinol. 2010 Feb;204(2):165-72.
7. Gao D, Griffiths HR, Bailey CJ. Oleate protects against palmitate-induced insulin resistance in L6 myotubes. Br J Nutr. 2009 Dec;102(11):1557-63.
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