刘健康 - 西安交通大学 - 前沿科学技术研究院

个人简介

教育背景 1982年西安交通大学化学专业理学士毕业 1986年中国协和医科大学中国医学科学院药物研究所- 中国化工部沈阳化工研究院联合培养天然药物化学专业硕士研究生班毕业 1994年日本岗山大学医学部神经科学专业博士毕业工作经历 1994-1996年美国加州大学伯克莱分校分子生化与分子生物学专业博士后 1997-2006年美国加州大学伯克莱分校分子细胞生物系担任研究助理教授及副教授（其中2000-2006同时在美国儿童医院奥克兰研究所担任助理研究员、副研究员，2003-2008任中国科学院上海生科院营养科学研究所研究员及营养与衰老分子细胞生物学研究组组长） 2006-2008年美国加州大学欧文分校研究副教授 2008-2012年美国肯塔基大学医学院教授（兼职） 2012年－美国南加州大学教授（兼职） 2008年9月任西安交通大学博士生导师

研究领域

长期从事营养对衰老及衰老相关疾病在分子细胞生物学水平上的调控研究，重点研究自由基生物学与线粒体代谢机制

近期论文

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Han S, Ren Y, He W, Liu H, Zhi Z, Zhu X, Yang T, Rong Y, Ma B, Purwin TJ, Ouyang Z, Li C, Wang X, Wang X, Yang H, Zheng Y, Aplin AE, Liu J*, Shao Y*.: ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma. Nat Commun. 2018 Jan 2;9(1):28. doi: 10.1038/s41467-017-02354-x. Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long J, Li Z, Shen W, Liu J. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death Differ. 2018 Feb;25(2):229-240. doi: 10.1038/cdd.2017.144. Epub 2017 Sep 15. Wang X, Feng Z, Wang X, Yang L, Han S, Cao K, Xu J, Zhao L, Zhang Y, Liu J. O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis. Diabetologia. 59(6): 1287-96, 2016. Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L, Wei W, Zou W. Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. Cell Res, 2016, 26(6): 699-712. Chen C, Han X, Zou X, Li Y, Yang L, Cao K, Xu J, Long J, Liu J*, Feng Z*.: 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem. 289(24): 17184-94, 2014. Zou X, Yan C, Shi Y, Cao K, Xu J, Wang X, Chen C, Luo C, Li Y, Gao J, Pang W, Zhao J, Zhao F, Li H, Zheng A, Sun W, Long J, Szeto IM, Zhao Y, Dong Z, Zhang P, Wang J, Lu W, Zhang Y, Liu J*, Feng Z*.: Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 21(11): 1557-70, 2014. Feng Z, Zou X, Jia H, Li X, Zhu Z, Liu X, Bucheli P, Ballevre O, Hou Y, Zhang W, Wang J, Chen Y and Liu J*: Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: Possible role of neuronal mitochondria metabolism. Antioxid Redox Signal 16(3): 275-89, 2012. Liu J*, Shen W, Zhao B, Wang Y, Wertz K, Weber P, Zhang P: Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients. Adv Drug Deliv Rev 61: 1343-52, 2009. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Cotman CW, and Liu J*: R-α-Lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in 3T3-L1 adipocytes. Diabetologia 51:165-174, 2008. Liu, J., Killilea, D., and Ames, B.N.: Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-a-lipoic acid. Proc Natl Acad Sci USA 99: 1876-1881, 2002. Liu., J., Head, E., Gharib, A., Yuan, W., Ingersoll, R. T., Hange, T. M., Cotman, C. W., and Ames, B.N.: Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-a-lipoic acid. Proc Natl Acad Sci USA 99: 2356-2361, 2002. Liu, J., Kuratsune, H., Atamna, H., and Ames, B.N.: Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann New York Acad Sci 959: 133-166, 2002.