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个人简介

01/2018至今,暨南大学附属第一医院纳米诊疗研究所所长、教授(博导) 12/2016至今,暨南大学化学与材料学院副院长、教授(博导) 10/2010至今,暨南大学化学系教授(博士生导师) 09/2015至今,广东省纳米化学创新药物工程技术研究中心主任 12/2008-09/2010,暨南大学化学系副教授(博士生导师) 08/2008-08/2009,香港中文大学生物系博士后研究员 08/2005–06/2008,香港中文大学生物系博士(化学生物学、细胞生物学) 09/2003–06/2005,暨南大学化学系硕士(生物无机化学) 09/1999–06/2003,暨南大学化学系学士(应用化学)

研究领域

硒纳米医学与疾病精准诊疗应用

近期论文

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Lizhen He, Qi Chen, Qichen Lu, Meijin Yang, Bin Xie, Tianfeng Chen*, Xun Wang*. Autophagy‐Inducing MoO3‐x Nanowires Boost Photothermal‐Triggered Cancer Immunotherapy. Angewandte Chemie. 2024, e202404822. Binhua Zou, Zushuang Xiong, Yanzi Yu, Sujiang Shi, Xiaoling Li*, Tianfeng Chen*. Rapid selenoprotein activation by selenium nanoparticles to suppresses osteoclastogenesis and pathological bone loss. Advanced Materials,2024,2401620. Rui Qiao#, Zhongwen Yuan#, Meijin Yang, Zhiying Tang, Lizhen He*, Tianfeng Chen*. Selenium-doped nanoheterojunctions for highly efficient cancer radiosensitization. Advanced Science, 2024 Haoqiang Lai, Ligeng Xu,* Chang Liu, Sujiang Shi, Yalin Jiang, Yangyang Yu, Bo Deng, Tianfeng Chen*. Universal selenium nanoadjuvant with immunopotentiating and redox-shaping activities inducing high-quality immunity for SARS-CoV-2 vaccine. Signal Transduction and Targeted Therapy, 2023, 8: 88. Wei Huang, Sujiang Shi, Haoran Lv, Zhenyu Ju, Qinghua Liu*, Tianfeng Chen*. Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer, Bioactive Materials, 2023, in press. Leung Chan#, Yongkang Liu#, Muhe Chen#, Yanhong Su, Junxian Guo, Liwen Zhu, Meixiao Zhan, Tianfeng Chen*, Ligong Lu*. Cuproptosis-Driven Enhancement of Thermotherapy by Sequentially Response Cu2-xSe via Copper Chemical Transition, Advanced Functional Materials, 2023, in press Fengzhi Zhao, Wei Huang, Lizhen He, Shiqing Nie, Zhiting Sun, Tianfeng Chen*, Haiyan Yin*, Jianfu Zhao*. Reversing lung cancer radioresistance by hyperpermeable tellurium nanotherapeutics via remodeling tumor microenvironment, Nano Today, 2023, 50, 101819 Chang Liu, Run Lin, Haoqiang Lai, Fen Pi, Qian Xue, Tianfeng Chen*, Weiling He*. Thermosensitive selenium hydrogel boosts antitumor immune response for hepatocellular carcinoma chemoradiotherapy, Nano Today, 2023, 50, 101823. Zushuang Xiong#, Hao Lin#, Hong Li, Binghua Zou, Bin Xie, Yanzi Yu, Lizhen He*, Tianfeng Chen*. Chiral Selenium Nanotherapeutics Regulates Selenoproteins to Attenuate Glucocorticoid-induced Osteoporosis, Advanced Functional Materials. 2023, DOI: 10.1002/adfm.202212970 Lizhen He, Jianfu Zhao, Hongjun Li, Bin Xie, Ligeng Xu, Guanning Huang, Ting Liu, Zhen Gu*, Tianfeng Chen*, Metabolic reprogramming of NK cells by black phosphorus quantum dots potentiates cancer immunotherapy, Advanced Science, 2023, in press. Guanlin Li#, Sicheng Wu#, Wenzhe Chen#, Xiaolu Duan, Xinyuan Sun, Shujue Li, Zanlin Mai, Wenzheng Wu, Guohua Zeng*, Hongxing Liu*, Tianfeng Chen*. Designing intelligent nanomaterials to achieve highly sensitive diagnoses and multimodality therapy of bladder cancer. Small Methods, 2023, 2201313. Shuya Pan, Guanning Huang, Zhengwei Sun, Xin Chen, Xinli Xiang, Wenxiao Jiang, Yanchao Xu, Tianfeng Chen*, Xueqiong Zhu*. X-ray-responsive Zeolitic Imidazolate Framework-capped Nanotherapeutics for Cervical Cancer-targeting Radiosensitization. Advanced Functional Materials. 2023, in press Mingkai Chen,† Wenqiang Cao,† Junping Wang,† Fei Cai, Liwen Zhu, Li Ma,* and Tianfeng Chen*. Selenium Atom-Polarization Effect Determines TrxR-Specific Recognition of Metallodrugs. J Am Chem Soc, 2022, 144, 45, 20825–20833. Wenxiao Jiang, Zhongyang Zhang, Miaomiao Ye, Shuya Pan, Guanning Huang, Tianfeng Chen⁎, Xueqiong Zhu⁎, Morphology-directed radiosensitization of MoSe2 nanoplatforms for promoting cervical cancer radiotherapy, Nano Today,2022, 46, 101598. Binhua Zou#, Zushuang Xiong#, Lizhen He*, Tianfeng Chen*. Reversing Breast Cancer Bone Metastasis by Metal Organic Framework-Capped Nanotherapeutics via Suppressing Osteoclastogenesis, Biomaterials, 285,121549. Zhenhuan Song, Ting Liu, Haoqiang Lai, Xiaofeng Meng, Liu Yang, Jianyu Su*, and Tianfeng Chen*. A Universally EDTA-Assisted Synthesis of Polytypic Bismuth Telluride Nanoplates with a Size-Dependent Enhancement of Tumor Radiosensitivity and Metabolism In Vivo, ACS Nano, 2022, 16, 3, 4379-4396 Jiang Ouyang, Qingyue Bu, Na Tao, Mingkai Chen, Haijun Liu, Jun Zhou, Jinggong Liu, Bo Deng, Na Kong, Xingcai Zhang*, Tianfeng Chen*, Yihai Cao, Wei Tao*. A Facile and General Method for Synthesis of Antibiotic-Free Protein-based Hydrogel: Wound Dressing for the Eradication of Drug-Resistant Bacteria and Biofilms. Bioactive Materials, 2022, 18,446-458. Xiaosheng Liang#, Ting Liu#, Linpeng Li#, Jieli Li, Shufang Li, Ke Zeng, Chao Song, Tianfeng Chen*, and Yi Zou*, Translational selenium nanotherapeutics counter-acts multiple risk factors to improve surgery-induced cognitive impairment. Chemical Engineering Journal, 2022, 441, 135984. Qi Chen#, Lizhen He#, Xiaoying Li, Ligeng Xu* and Tianfeng Chen*. Ruthenium Complexes Boost NK Cell Immunotherapy via Sensitizing Triple-negative Breast Cancer and Shaping Immuno-microenvironment, Biomaterials, 2022, 281, 121371. Guanning Huang†, Jiankun Zang†, Lizhen He†, Huili Zhu†, Jiarun Huang, Zhongwen Yuan, Tianfeng Chen*, Anding Xu*, Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke, ACS Nano, 2022, 16, 1, 431–452. Wei Huang, Lizhen He*, Zhongyang Zhang, Sujiang Shi, and Tianfeng Chen*. Shape-Controllable Tellurium-Driven Heterostructures with Activated Robust Immunomodulatory Potential for Highly Efficient Radiophotothermal Therapy of Colon Cancer, ACS Nano, 2021, 15, 12, 20225–20241. Hui Yang#, Chang Liu#, Yanjun Wu, Meng Yuan, Jiarun Huang, Yuhan Xia, Qinjie Ling, Peter R. Hoffmann, Zhi Huang*, Tianfeng Chen*. Atherosclerotic Plaque-targeted Nanotherapeutics Ameliorates Atherogenesis by Blocking Macrophage-driven Inflammation, Nano Today,2022, 101351. Weiqiang Lin#, Hongxing Liu#, Lingwu Chen, Junxing Chen, Dong Zhang, Qingqing Cheng, Fang Yang, Qinsong Zeng*, Tianfeng Chen*. Pre-clinical MRI-guided intravesical instillation theranosis of bladder cancer by tumor-selective oxygen nanogenerator, Nano Today, 2021, 38, 101124. Ting Liu, Xi Zhang, Lizhen He, Zehang Zhang, Junmei Feng, Zhiming Lin*, Tianfeng Chen*. Specific Nanotherapeutics for Highly Efficient Diagnosis and Treatment of Systemic Lupus Erythematosus, Chemical Engineering Journal, 2022, 133095. Runcong Liu, Yongjun Peng, Ligong Lu, Shaojun Peng*, Tianfeng Chen* and Meixiao Zhan*, Near-Infrared Light-Triggered Nano-prodrug for Cancer Gas Therapy, Journal of Nanobiotechnology, 2021, 19:443. Mingkai Chen, Xiaoting Huang, Huatian Shi, Jie Lai, LiMa*, Tai-Chu Lau*, Tianfeng Chen*. Cr(V)–Cr(III) in-situ transition promotes ROS generation to achieve efficient cancer therapy. Biomaterials, 2021, 276, 120991. Lizhen He#, Guanning Huang#, Hongxing Liu, Chengcheng Sang, Xinxin Liu, Tianfeng Chen*. Highly bioactive zeolitic imidazolate framework-capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke.Science Advances, 2020; 6: eaay9751. Wei Huang, Lizhen He, Jiang Ouyang, Qi Chen, Chuang Liu, Wei Tao*, and Tianfeng Chen*. Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy. Matter, 2020, 3, 1725-1753. Zhongyang Zhang, Zhongmin Tang, Nika Farokhzad, Tianfeng Chen,* and Wei Tao*. Sensitive, Rapid, Low-Cost, and Multiplexed COVID-19 Monitoring by the Wireless Telemedicine Platform. Matter, 2020, 3, 1818–1831. Leung Chan#, Xiaodan Chen#, Pan Gao, Jun Xie, Zhongyang Zhang, Jianfu Zhao, Tianfeng Chen*. Coordination-Driven Enhancement of Radiosensitization by Black Phosphorus via Regulating Tumor Metabolism. ACS Nano, 2021, 15, 2, 3047 Jiang Ouyang, Ling Zhang, Leijiao Li, Zhongmin Tang, Xiaoyuan Ji, Chan Feng, Na Tao, Na Kong, Tianfeng Chen*, You-Nian Liu*, Wei Tao*. Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics. Nano-Micro Letters, 2021, 13:90. Ting Liu#, Ligeng Xu#, Lizhen He, Jianfu Zhao, Zehang Zhang, Qi Chen, Tianfeng Chen*. Selenium Nanoparticles Regulates Selenoprotein to Boost Cytokine-Induced Killer Cells-Based Cancer Immunotherapy. Nano Today, 2020, 35, 100975. Zhuo Wang‡, Lizhen He‡, Bingqing Liu,Li-Peng Zhou, Li-Xuan Cai, Shao-Jun Hu, Xiao-Zhen Li, Zhikai Li, Tianfeng Chen,* Xiaopeng Li,*Qing-Fu Sun*. Coordination-Assembled Water-Soluble Anionic Lanthanide Organic Polyhedra for Luminescent Labeling and Magnetic Resonance Imaging. J. Am. Chem. Soc., 2020, 142, 38, 16409–16419. Hao-Yan Yin, Jiu-Jiao Gao, Xuemin Chen, Bin Ma, Zi-Shu Yang, Juan Tang, Bing-Wu Wang, Tianfeng Chen*, Chu Wang*, Song Gao, Jun-Long Zhang*. A Gallium(III) Complex that Engages Protein Disulfide Isomerase A3 (PDIA3) as an Anticancer Target. Angew Chem Int Edit, 2020, 59, 20147-20153. Liu, Chang; Lai, Haoqiang; Chen, Tianfeng*. Boosting Natural Killer Cell-Based Cancer Immunotherapy with Selenocystine/Transforming Growth Factor-Beta Inhibitor-Encapsulated Nanoemulsion. ACS Nano, 2020, 14, 9, 11067. Jing Wang, Yanzhou Chang, Hui Luo, Wenxiao Jiang, Ligeng Xu, Tianfeng Chen*, Xueqiong Zhu*. Designing Immunogenic Nanotherapeutics for Photothermal-Triggered Immunotherapy Involving Reprogramming Immunosuppression and Activating Systemic Antitumor Responses. Biomaterials, 2020, 120153. Hongxing Liu†, Chaoming Mei†, Xuanru Deng, Weiqiang Lin, Lizhen He, Tianfeng Chen*. Rapid visualizing and pathological grading of bladder tumor tissues by simple nanodiagnostics, Biomaterials, 2021, 264, 120434. Zhennan Zhao, Pan Gao, Li M* and Tianfeng Chen*. A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy. Chemical Science, 2020, 11, 3780 - 3789 Lizhen He, Li-Xuan Cai, Meng-Hua Li, Guang-Lu Zhang, Li-Peng Zhou, Tianfeng Chen*, Mei-Jin Lin* and Qing-Fu Sun*. Designing a highly stable coordination-driven metallacycle for imaging-guided photodynamic cancer theranostics, Chemical Science, 2020, 11, 7940-7949. JuanjuanLi, TianfengChen*. Transition metal complexes as photosensitizers for integrated cancer theranostic applications, Coordination Chemistry Reviews, 2020, 418, 213355. Yuanyuan You, Zhennan Zhao, Lizhen He, Zhibo Sun, Dong Zhang, Changzheng Shi, Qingqing Cheng, Yiyong Liu, Liangping Luo, Tianfeng Chen*. Long-term Oxygen Storage Nanosystem for Near-Infrared Light-Triggered Oxygen Supplies to Antagonize Hypoxia-induced Therapeutic Resistance in Nasopharyngeal Carcinoma. Advanced Functional Materials. 2020, 2002369. Yanyu Huang†, Yuanting Fu†, Mengting Li, Dawei Jiang, Christopher J. Kutyreff, Jonathan W. Engle, Xiaoli Lan, Weibo Cai*, Tianfeng Chen*. Chirality-driven transportation and oxidation prevention by chiral selenium nanoparticles. Angew Chem Int Edit, 2020, 59, 4406-4414. Frontispiece Yanhong Duo#, Yanyu Huang#, Weiyuan Liang#, Riming Yuan, Yang Li, Tianfeng Chen*, Han Zhang*. Ultraeffective Cancer Therapy with an Antimonene-Based X-Ray Radiosensitizer. Advanced Functional Materials. 2019, 1906010. Hongxing Liu, Weiqiang Lin, Lizhen He*, Tianfeng Chen*. Radiosensitive Core/Satellite Ternary Heteronanostructure for Multimodal Imaging-Guided Synergistic Cancer Radiotherapy. Biomaterials, 2020, 119545. Chengli Dai †, ZhengTang †, Xiaoling Li, Tianfeng Chen*. High-pressure homogenization and tailoring of size-tunable Ganoderma lucidum spore oil nanosystem for enhanced anticancer therapy. Chemical Engineering Journal, 2021, 406, 127125 Riming Yuan†, Yanyu Huang†, Leung Chan, Dihao He, Tianfeng Chen*. Engineering EHD1-Targeted Natural Borneol Nanoemulsion Potentiates Therapeutic Efficacy of Gefitinib against Nonsmall Lung Cancer. ACS Applied Materials & Interfaces, 2020, 12, 45714-45727 Lanhai Lai, Zushuang Xiong, Li Ma*, Tianfeng Chen*. Smart Microenvironment-Responsive Organocopper (II) Supramolecular Polymers to Regulate the Stability and Anticancer Efficacy by Different Substituents. ACS Applied Materials & Interfaces, 2020, 12, 40013-40020 Yahui Yang, Yifan Wang, Ligeng Xu*, Tianfeng Chen*. Dual-functional Se/Fe complex facilitates TRAIL treatment against resistant tumor cells via modulating cellular endoplasmic reticulum stress. Chinese Chemical Letters, 2020, 31, 1801-1806 Haoqiang Lai, Xiaobin Zhang, Zhenhuan Song, Zhongwen Yuan, Lizhen He*, Tianfeng Chen*. Facile synthesis of antioxidative nanotherapeutics using a microwave for efficient reversal of cisplatin-induced nephrotoxicity. Chemical Engineering Journal, 2020, 391, 123563 Yuanwei Liang, Delong Zeng, Yuanyuan You, Bin Ma, Xiaoling Li, Tianfeng Chen*. Designing Dihydrofolate Reductase Inhibitors as X-ray Radiosensitizers to Reverse Radioresistance of Cervical Cancer. ACS Medicinal Chemistry Letters, 2020, 11, 1421-1428 Liyuan Hou, Wei Huang, Jiaqi Cheng, Xuanru Deng, Haoqiang Lai, Zhen Chen, Zepang Zhan, Pengju Feng, Yiqun Li, Fang Yang*, Tianfeng Chen*. The investigation and bioorthogonal anticancer activity enhancement of a triphenylphosphine-labile prodrug of seleno-combretastatin-4. Chemical Communications, 2020, 56, 14495-14498 Haoqiang Lai, Chang Liu, Liyuan Hou, Wenwei Lin, Tianfeng Chen*, An Hong*. TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin. Theranostics, 2020, 10, 10154 Jinggong Liu, Yongjin Li, Song Chen, Yongpeng Lin, Haoqiang Lai, Bolai Chen*, Tianfeng Chen*. Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases. Frontiers in Chemistry, 2020, 8, 838 Fan Yang, Jiarun Huang, Hongxing Liu, Weiqiang Lin, Xiaoling Li*, Xueqiong Zhu, Tianfeng Chen*. Lentinan-functionalized selenium nanosystems with high permeability infiltrate solid tumors by enhancing transcellular transport. Nanoscale, 2020, 12, 14494-14503 Haoqiang Lai, Delong Zeng, Chang Liu, Qi Zhang, and Tianfeng Chen*. Selenium-containing Ruthenium Complex synergizes with Natural Killer Cells to Enhance Immunotherapy Against Prostate Cancer via Activating TRAIL/FasL Signaling, Biomaterials, 2019,219, 119377 Yi Hu#, Ting Liu#, Jingxia Li#, Fengyi Mai, Jiawei Li, Yan Chen, Yanyun Jing, Xin Dong, Li Lin, Junyi He, Yan Xu, Changliang Shan, Jianlei Hao, Zhinan Yin, Tianfeng Chen*, Yangzhe Wu*. Selenium nanoparticles potentiate γδ T cell anti-tumor cytotoxicity by upregulation of tubulin-a acetylation, Biomaterials, 2019, 119397. Lizhen He, Tianqi Nie, Xiaojun Xia, Ting Liu, Yanyu Huang, Xiaojuan Wang, Tianfeng Chen*. Designing Bioinspired 2D MoSe2 Nanosheet for Efficient Photothermal-Triggered Cancer Immunotherapy with Reprogramming Tumor-associated Macrophages.Advanced Functional Materials. 2019, 1901240. (Back Cover) Chengli Dai, Lizhen He, Bin Ma, Tianfeng Chen*. Facile Nanolization Strategy for Therapeutic Ganoderma Lucidum Spore Oil to Achieve Enhanced Protection against Radiation-Induced Heart Disease, Small, 2019, 1902642. Pengju Feng,* Guojian Ma, Xiaoguang Chen, Xing Wu, Ling Lin, Peng Liu and Tianfeng Chen* Electro-oxidative and Regioselective C-H Azolation of Phenol and Aniline Derivatives, Angew Chem Int Edit, 2019, 58, 8400-8404. Chan, Leung ; Gao, Pan ; Zhou, Wenhua ; Mei, Chaoming ; Huang, Yanyu; Yu, Xue-Feng*; Chu, Paul; Chen, Tianfeng*. Sequentially Triggered Delivery System of Black Phosphorus Quantum Dots with Surface Charge Switching Ability for Precise Tumor Radiosensitization. ACS Nano, 2018, 12, 12401–12415. Chaoming Mei, Ni Wang, Xueqiong Zhu, Ka-Hing Wong, Tianfeng Chen*. Photothermal-controlled Nanotubes with Surface Charge Flipping Ability for Precise Synergistic Therapy of Triple-negative Breast Cancer. Advanced Functional Materials. 2018, 1805225. Lizhen He, Tianfeng Chen*, Yuanyuan You, Hao Hu, Wenjie Zheng, Wai-Lun Kwong, Taotao Zou and Chi-Ming Che*. A Cancer-Targeted Nanosystem for Delivery of Anti-Cancer Gold(III) Complexes: Enhanced Selectivity and Apoptosis-Inducing Efficacy of Gold(III) Porphyrin. Angew Chem Int Edit, 2014, 53(46), 12532-12536. Wen Liu, Xiaoling Li, Yum-Shing Wong, Wenjie Zheng*, Yibo Zhang, Wenqiang Cao, Chen Tianfeng*. Selenium nanoparticles as a carrier of 5-Fluorouracil to achieve anticancer synergism. ACS Nano, 2012, 6 (8), 6578–6591.

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