朱光宇 - 香港城市大学 - 生物医学科学系

个人简介

B.S. Peking University (2002) Ph.D. University of Pittsburgh (2007) Postdoc, MIT (2011) Dr. Guangyu Zhu obtained his B.Sc. in Chemistry from Peking University (2002), where he developed a strong passion for biological chemistry and drug discovery. He moved to the United States and obtained a Ph.D. in Biological Chemistry from the Department of Chemistry at the University of Pittsburgh (2007), where he worked on anticancer drug development and discovery. He subsequently did his postdoc at the Massachusetts Institute of Technology (MIT), working on the mechanism of action of cisplatin, one of the most widely used chemotherapeutic drugs in the clinic. He joined the City University of Hong Kong as an Assistant Professor in 2011. Dr. Zhu's research interest lies at the interface of chemistry and biology, focusing on anticancer drug development and mechanism. His current research projects include the synthesis and biological evaluation of novel metal-based anticancer agents, the development of cancer-specific nanomedicine to conquer cisplatin resistance, and the screening of biologically active small-molecule anticancer agents and their target validation, by using interdisciplinary approaches and methods in the areas of biological chemistry, medicinal chemistry, molecular biology, and chemical biology.

研究领域

Research Overview The research in the Zhu Group lies at the interface of chemistry and biology in the study of the mechanisms of anticancer drugs, especially DNA-damaging agents, and the development of innovative anticancer complexes. Our interdisciplinary approach conjoins bioinorganic chemistry, chemical biology, medicinal chemistry, and drug discovery, with a focus on the synthesis and biological evaluations of multifunctional and non-conventional metal-based anticancer agents and on the development of photoactivatable anticancer prodrugs and functionalized nanomedicine. Research Interests Anticancer drug development and mechanism; chemical biology; nanomedicine; drug delivery

近期论文

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Yan, Q., Duan, M., Chen, C., Deng, Z., Wu, M., Yu, P., He, M.*, Zhu, G.*, Houk, K. N.*, and Sun, J.* (2022) Organocatalytic discrimination of non-directing aryl and heteroaryl groups: enantioselective synthesis of bioactive indole-containing triarylmethanes. Chem. Sci. 13, 5767–5773 Yao, H., Wang, Z.*, Wang, N., Deng, Z., Liu, G., Zhou, J., Chen, S., Shi, J., and Zhu, G.* (2022) Enhancing circulation and tumor accumulation of carboplatin via an erythrocyte-anchored prodrug strategy. Angew. Chem. Int. Ed. 61, e202203838 Ma, L., Li, L., and Zhu, G.* (2022) Platinum-containing heterometallic complexes in cancer therapy: advances and perspectives. Inorg. Chem. Front. 9, 2424–2453 Yao, H., and Zhu, G.* (2022) A platinum-based fluorescent “turn on” sensor to decipher the reduction of platinum(IV) prodrugs. Dalton Trans. 51, 5394–5398 Chen, S., Ng, K. Y., Zhou, Q., Yao, H., Deng, Z., Tse, M.-K., and Zhu, G.* (2022) The influence of different carbonate ligands on the hydrolytic stability and reduction of platinum(IV) prodrugs. Dalton Trans. 51, 885–897 Li, B., Liu, J., Lyu, F., Deng, Z., Yi, B., Du, P., Yao, X., Zhu, G., Xu, Z., Lu, J., and Li, Y. Y. (2022) Mineral hydrogel from inorganic salts: biocompatible synthesis, all-in-one charge storage, and possible implications in the origin of life. Adv. Funct. Mater. 32, 2109302 Xue, Y., Feng, X., Fan, X., Zhu, G., McLaughlan, J., Chen, X., and Zhang, W. (2022) Exosomes for early diagnosis of cancers. Small Struct. 3, 2100096 Wang, N., Deng, Z., Zhu, Q., Zhao, J., Xie, K., Shi, P., Wang, Z., Chen, X., Wang, F., Shi, J., and Zhu, G.* (2021) An erythrocyte-delivered and near-infrared photoactivatable oxaliplatin nanoprodrug for enhanced antitumor efficacy and immune response. Chem. Sci. 12, 14353-14362 Yao, H., Gunawan, Y. F., Liu, G., Tse, M.-K., and Zhu, G.* (2021) Optimization of axial ligands to promote the photoactivation of BODIPY-conjugated platinum(IV) anticancer prodrugs. Dalton Trans. 50, 13737–13747 Zhou, B., Ou, W., Zhao,C., Shen, J., Zhang, G., Tang, X., Deng, Z., Zhu, G., Li, Y. Y., Lu, J. (2021) Insertable and reusable SERS sensors for rapid on-site quality control of fish and meat products. Chem. Eng. J. 426, 130733 Qi, S., Zhang, Y., Liu, G., Chen, J., Li, X., Yang, Y., Shi, J., Lee, C.-S., Lai, P.*, Zhu, G.*, Wang, L.*, and Fang, C.* (2021) Plasmonic-doped melanin-mimic for CXCR4-targeted NIR-II photoacoustic computed tomography-guided photothermal ablation of orthotopic hepatocellular carcinoma. Acta Biomater. 129, 245-257 Xu, Z., Tang, W. K., Zhou, Q., Chen, S., Siu, C.-K.*, and Zhu, G.* (2021) On the hydrolytic stability of unsymmetric platinum(IV) anticancer prodrugs containing axial halogens. Inorg. Chem. Front. 8, 3794-3802 Xu, Z., Deng, Z., Wang, Z., and Zhu, G.* (2021) Recent advances in the synthesis, stability, and activation of Pt(IV) prodrugs. Coord. Chem. Rev. 442, 213991 Deng, Z., Li, C., Chen, S., Zhou, Q., Xu, Z., Wang, Z., Yao, H., Hirao, H., and Zhu, G.* (2021) An intramolecular photoswitch can significantly promotes photoactivation of Pt(IV) prodrugs. Chem. Sci. 12, 6536-6542 Ren, B., Chen, B., Zhao, J., Guo, Y., Zhang X., Chen, X., Du, Y., Deng, Z., Zhu, G., and Wang, F. (2021) Synthesis of core–shell ScF3 nanoparticles for thermal enhancement of upconversion. Chem. Mater. 33, 158-163 Deng, Z., Wang, N., Ai, F., Wang, Z.*, and Zhu, G.* (2021) Nanomaterial-mediated platinum drug-based combinatorial cancer therapy. VIEW 2, 20200030 Li, X.†, Duan, M.†, Deng, Z.†, Shao, Q., Chen, M., Zhu, G.*, Houk, K.N.*, and Sun, J.* (2020) Catalytic enantioselective synthesis of chiral tetraarylmethanes. Nat. Catal. 3, 1010-1019 Yao, H., Chen, S., Deng, Z., Tse, M.-K., Matsuda, Y., and Zhu, G.* (2020) BODI-Pt, a green-light activatable and carboplatin-based platinum(IV) anticancer prodrug with enhanced activation and cytotoxicity. Inorg. Chem. 59, 11823–11833 Chen, S., Yao, H., Zhou, Q., Tse, M.-K., Gunawan, Y. F., and Zhu, G.* (2020) Stability, reduction, and cytotoxicity of platinum(IV)-based anticancer prodrugs bearing carbamate axial ligands: Comparison with their carboxylate analogues. Inorg. Chem. 59, 11676–11687 Deng, Z., Wang, N., Liu, Y., Xu, Z., Wang, Z., Lau, T.-C., and Zhu, G.* (2020) A photocaged, water-oxidizing, and nucleolus-targeted Pt(IV) complex with a distinct anticancer mechanism. J. Am. Chem. Soc. 142, 7803-7812 Du, Y., Wang, Y., Deng, Z., Chen, X., Yang, X., Sun, T., Zhang, X., Zhu, G., Yu, S. F., and Wang, F. (2020) Blue-pumped deep ultraviolet lasing from lanthanide-doped Lu6O5F8 upconversion nanocrystals. Adv. Opt. Mater. 8, 1900968 Xu, Z., Li, C., Zhou, Q., Deng, Z., Tong, Z., Tse, M.-K., and Zhu, G.* (2019) Synthesis, cytotoxicity, and mechanistic investigation of platinum(IV) anticancer prodrugs conjugated with poly(ADP-ribose) polymerase (PARP) inhibitors. Inorg. Chem. 58, 16279-16291 Wang, Z.*, Wang, N., Cheng, S.-C., Xu, K., Deng, Z., Chen, S., Xu, Z., Xie, K., Tse, M.-K., Shi, P., Hirao, H., Ko, C.-C., and Zhu, G.* (2019) Phorbiplatin, a highly potent Pt(IV) antitumor prodrug that can be controllably activated by red light. Chem 5, 3151-316 Yan, L., Gonca, S., Zhu, G., Zhang, W., and Chen, X. (2019) Layered double hydroxide nanostructures and nanocomposites for biomedical applications. J. Mater. Chem. B 7, 5583-5601 Yao, H., Xu, Z., Li, C., Tse, M.-K., Tong, Z., and Zhu, G.* (2019) Synthesis and cytotoxic study of a platinum(IV) anticancer prodrug with selectivity towards LHRH-receptor positive cancer cells. Inorg. Chem. 58, 11076-11084 Chen, B., Kong, W., Wang, N., Zhu, G.*, and Wang, F.* (2019) Oleylamine-mediated synthesis of small NaYbF4 nanoparticles with tunable size. Chem. Mater. 31, 4779-4786 Li, C., Li, T., Huang, L.*, Yang, M.*, and Zhu, G.* (2019) Self-assembled lipid nanoparticles for ratiometric codelivery of cisplatin and siRNA targeting XPF to combat drug resistance in lung cancer. Chem. Asian J. 14, 1570-1576 Wang, A., Kang, F., Wang, Z., Shao, Q., Li, Z., Zhu, G., Lu, J., and Li, Y. Y. (2019) Facile synthesis of nitrogen-rich carbon dots as fertilizers for mung bean sprouts. Adv. Sustainable Syst. 3, 1800132 Wang, Z., Deng, Z., and Zhu, G.* (2019) Emerging platinum(IV) prodrugs to combat cisplatin resistance: From isolated cancer cells to tumor microenvironment. Dalton Trans. 48, 2536-2544