Fan, Timothy - University of Illinois at Urbana-Champaign - Department of Veterinary Clinical Medicine

个人简介

Education PhD, University of Illinois DVM, Virginia-Maryland Regional College of Veterinary Medicine BS, Virginia Polytechnic Institute and State University Honors and Awards Chicago Veterinary Medical Association Outstanding Instructor Award

研究领域

Comparative oncology is the study of tumor histologies which closely share similar biology, genetics, and clinical behavior among various vertebrate species. A major theme of the Comparative Oncology Research Laboratory is to conduct anticancer research which can benefit both companion animals and human beings. By evaluating novel drugs or drug delivery strategies in dogs with spontaneously-arising tumor, the Comparative Oncology Research Laboratory is able to collaborate with basic scientists and aid in the investigation and characterization of novel anticancer treatment strategies. Through these joint studies, investigational therapies can be studied in large mammalians which develop tumors naturally, providing an experimental model system which most accurately mimics cancer development and progression in people.

近期论文

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Peterson QP, Hsu DC, Novotny CJ, West DC, Schmit JM, Dirikolu L, Hergenrother PJ, Fan TM. Discovery and canine preclinical assessment of a non-toxic procaspase-3 activating compound. Cancer Res. Sept 2010. Fan TM. Animal models of osteosarcoma. Expert Reviews of Anticancer Therapy. September 2010, Vol. 10, No. 8, 1327-1338. Paoloni M, Mazcko C, Fox E, Fan TM, Lana S, Kisseberth W, Vail D, Nuckolls K, Osborne T, Yalkowsy S, Gustafson D, Yu Y, Cao L, Khanna C. Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs. PLoS One. 2010 Jun 8;5(6):e11013. Lucas PW, Schmit JM, Peterson QP, West DC, Hsu DC, Novotny CJ, Dirikolu L, Churchwell MI, Doerge DR, Garrett LD, Hergenrother PJ, Fan TM. Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs. Invest New Drugs. 2010. Tong R, Coyle VJ, Tang T, Barger AM, Fan TM, Cheng J. Polylactide Nanoparticles Containing Stably-Incorporated Cyanine Dyes for In Vitro and In Vivo Imaging Applications. Microsc Res Tech. 2010 Sep;73(9):901-9 Tong R, Yala L, Fan TM, Cheng J. The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells. Biomaterials. 2010 Apr;31(11):3043-53. Dirikolu L, Chakkath T, Fan TM, Mente NR. Synthesis of trans- and cis-4'-Hydroxylomustine and Development of Validated Analytical Method for Lomustine and trans- and cis-4'-Hydroxylomustine in Canine Plasma. J Anal Toxicol. 2009 Nov-Dec;33(9):595-603. Fan TM, S.C. Charney, L.P. de Lorimier, L.D. Garrett, D.J. Griffon, W.J. Gordon-Evans, J.M. Wypij. Double-Blind Placebo-Controlled Trial of Adjuvant Pamidronate with Palliative Radiotherapy and Intravenous Doxorubicin for Canine Appendicular Osteosarcoma Bone Pain. J Vet Intern Med. 2009 Jan-Feb;23(1):152-160. Fan TM, Barger AM, Sprandel IT, Fredrickson RL. Investigating the expression of TrkA in canine osteosarcoma. J Vet Intern Med. 2008 Sep-Oct;22(5):1181-8. Fan TM, Barger AM, Fredrickson RL, Fitzsimmons D, Garrett LD. Investigating the expression of CXCR4 in canine osteosarcoma. J Vet Intern Med. 2008 May-Jun;22(3):602-8. Fan TM, Kranz DM, Flavell RA, Roy EJ. Costimulatory Strength Influences the Differential Effects of Transforming Growth Factor-1 for the Generation of CD8+ Regulatory T Cells. Mol Immunol. 2008 May;45(10):2937-50. Fan TM, de Lorimier LP, Garrett LD, Lacoste HI. The Bone Biologic Effects of Intravenous Zoledronate in Healthy Dogs and Dogs with Malignant Osteolysis. J Vet Intern Med. 2008 Mar-Apr;22(2):380-7. Barger AM, Fan TM, de Lorimier LP, et al. Expression of receptor activator of nuclear factor kappa-B ligand (RANKL) in neoplasms of dogs and cats. J Vet Intern Med. 2007 Jan-Feb;21(1):133-40. Fan TM, de Lorimier LP, O'Dell-Anderson K, et al. Single-agent pamidronate for palliative therapy of canine appendicular osteosarcoma bone pain. J Vet Intern Med. 2007 May-Jun;21(3):431-9. Fan TM, Kranz DM, Roy EJ. Enhancing antitumor immunity: combining IL-12 with TGF-1 antagonism. J Immunother (1997). 2007 Jul-Aug;30(5):479-89.