焦宁 - 北京大学

个人简介

Education 1995-1999 B.S. Organic Chemistry Shandong University, Ji’nan, P. R. China 1999-2004 Ph. D. (Supervisor: Prof. Shengming Ma)Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Professional Experience 2004-2006 Postdoctor (Supervisor: Professor Manfred T. Reetz), Alexander von Humboldt Fellowship Max Planck Institute für Kohlenforschung (MPI) Mülheim an der Ruhr, Germany 2007- Associate Professor, Professor State Key Laboratory of Natural and Biomimetic Drugs, Peking University

研究领域

We hope to develop some green and efficient synthetic methodologies for the synthesis of heterocycles, bioactive molecules and potential drugs by the strategies of radical reactions, the activation of inert chemical bonds, and highly selective reaction design.

近期论文

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Late-Stage Halogenation of Complex Substrates with Readily Available Halogenating Reagents Weijin Wang, Song Song*, Ning Jiao* Acc. Chem. Res. 2024, acs.accounts.4c00501. DOI: 10.1021/acs.accounts.4c00501 Selective Upcycling of Polyolefins into High-Value Nitrogenated Chemicals Binzhi Zhao, Zhibin Hu, Yichen Sun, Rehemuhali Hajiayi, Teng Wang, Ning Jiao* J. Am. Chem. Soc. 2024, jacs.4c07965. DOI: 10.1021/jacs.4c07965 Research progress on GPX4 targeted compounds Bingru Li†, Keguang Cheng†, Tzumei Wang, Xing Peng, Ping Xu, Guoquan Liu, Dong Xue, Ning Jiao, Chao Wang* Eur. J. Med. Chem. 2024, 274, 116548. DOI: 10.1016/j.ejmech.2024.116548 Carbene-Assisted Arene Ring-Opening Zengrui Cheng†, Haoran Xu†, Zhibin Hu, Minghui Zhu, K. N. Houk*, Xiao-Song Xue*, Ning Jiao* J. Am. Chem. Soc. 2024, jacs.4c03634. DOI: 10.1021/jacs.4c03634 Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation Xiaodong Dou†, Tongyu Huo†, Yameng Liu†, Zichen Pang, Lingyu Su, Xinyi Zhao, Xing Peng, Zhenming Liu, Liangren Zhang, Ning Jiao* Eur. J. Med. Chem. 2024, 116323. DOI: 10.1016/j.ejmech.2024.116323 Dioxygen compatible electron donor-acceptor catalytic system and its enabled aerobic oxygenation Jialiang Wei, Junhong Meng, Caifang Zhang, Yameng Liu, Ning Jiao* Nat. Commun. 2024, 15, 1886. DOI: 10.1038/s41467-024-45866-z Catalytic Conversion of Mixed Polyolefins under Mild Atmospheric Pressure Binzhi Zhao, Hui Tan, Jie Yang, Xiaohui Zhang, Zidi Yu, Hanli Sun, Jialiang Wei, Xinyi Zhao, Yufeng Zhang, Lili Chen, Dali Yang, Jin Deng, Yao Fu, Zheng Huang, Ning Jiao* The Innovation 2024, 5 (2), 100586. DOI: 10.1016/j.xinn.2024.100586 C—F Bond Insertion into Indoles with CHBr2F: An Efficient Method to Synthesize Fluorinated Quinolines and Quinolones Chao Li, Lei Chen, Hongye Wang, Zixi Yan, Bin Lyu, Weiping Lyu, Changwei Jiang, Dehua Lu, Jiaxing Li, Ning Jiao, Song Song* Chin. J. Chem. 2024, 42 (10), 1128–1132. DOI: 10.1002/cjoc.202400033 Organic Synthesis through Radical Innovation: Frustrated Radical Pairs Zhibin Hu, Zengrui Cheng, Ning Jiao* Chin. J. Chem. 2024, 42 (10), 1157–1160. DOI: 10.1002/cjoc.202300665 A Catalytic Method to Activate Nitromethane by the Cooperation of Homo- and Heterogeneous Catalysis Weijin Wang, Jianzhong Liu, Licheng Yang, Song Song*, Ning Jiao* Angew. Chem. Int. Ed. 2024, 63 (7), e202312354. DOI: 10.1002/anie.202312354 Nitromethane Assisted Brønsted Acid Catalyzed Regioselective Halogenation of Alkyl Aromatics Shihui Shi, Song Song*, Ning Jiao* Mol. Catal. 2024, 553, 113777. DOI: 10.1016/j.mcat.2023.113777 Discovery of 3-Oxo-1,2,3,4-Tetrahydropyrido[1,2-a]Pyrazin Derivatives as SARS-CoV-2 Main Protease Inhibitors through Virtual Screening and Biological Evaluation Xiaodong Dou†, Qi Sun†, Yameng Liu†, Yangbin Lu, Caifang Zhang, Guofeng Xu, Yue Xu, Tongyu Huo, Xinyi Zhao, Lingyu Su, Yihong Xing, Luhua Lai*, Ning Jiao* Bioorg. Med. Chem. Lett. 2024, 97, 129547. DOI: 10.1016/j.bmcl.2023.129547 Carbon–Carbon Bond Cleavage for Late-Stage Functionalization Yufeng Liang*, Muhammad Bilal, Leyu Tang, Tianzhang Wang, Yuqiu Guan, Zengrui Cheng, Minghui Zhu, Jialiang Wei, Ning Jiao* Chem. Rev. 2023, 123 (22), 12313–12370. DOI: 10.1021/acs.chemrev.3c00219 Regioselective Synthesis of 4-Functionalized Pyridines Chao Li†, Zixi Yan†, Bingding Wang, Jiaxing Li, Weiping Lyu, Zhixing Wang, Ning Jiao*, Song Song* Chem 2023, S2451929423005223. DOI: 10.1016/j.chempr.2023.10.015 Late-Stage Modification of Bioactive Compounds: Improving Druggability through Efficient Molecular Editing Tongyu Huo†, Xinyi Zhao†, Zengrui Cheng, Jialiang Wei, Minghui Zhu, Xiaodong Dou*, Ning Jiao* Acta Pharm. Sin. B 2023, S2211383523004446. DOI: 10.1016/j.apsb.2023.11.021 Functional Screening and Rational Design of Compounds Targeting GPR132 to Treat Diabetes Jiale Wang†, Xiaodong Dou†, Jie Cheng†, Mingxin Gao†, Guofeng Xu†, Wei Ding†, Jinhui Ding†, Yu Li, Sihan Wang, Zhaowei Ji, Xinyi Zhao, Tongyu Huo, Caifang Zhang, Yameng Liu, Xueying Sha, Jiarui Gao, Wenhui Zhang, Yong Hao, Cheng Zhang, Jinpeng Sun*, Ning Jiao*, Xiao Yu* Nat. Metab. 2023, 5 (10), 1726–1746. DOI: 10.1038/s42255-023-00899-4 Organocatalytic Deoxyhalogenation of Alcohols with Inorganic Halides Weijin Wang†, Hongye Wang†, Rongheng Dai†, Yachong Wang, Zhaoting Li, Xiaoxue Yang, Bin Lu, Ning Jiao, Song Song* ACS Catal. 2023, 13 (13), 9033–9040. DOI: 10.1021/acscatal.3c02078 Aminotetrazole Synthesis from Secondary Amides by C–C Bond Nitrogenation Cheng Zhang, Jianzhong Liu, Zengrui Cheng, Junhua Li, Song Song, Ning Jiao* Synlett 2023, 34 (12), 1534–1538. DOI: 10.1055/a-2006-4548 Nitrogenation of Amides via C–C and C–N Bond Cleavage Minghui Zhu, Zengrui Cheng, Jialiang Wei, Hui Tan, Ning Jiao* CCS Chemistry 2023, 5 (5), 1061–1068. DOI: 10.31635/ccschem.022.202202585 Recent Applications of Trifluoromethanesulfonic Anhydride in Organic Synthesis Qixue Qin†, Zengrui Cheng†, Ning Jiao* Angew. Chem. Int. Ed. 2023, 62 (10), e202215008. DOI: 10.1002/anie.202215008 Rhodium-Catalyzed Transannulation of 1,2,3‐THIAZOLES with Alkynes for the Direct Synthesis of Thiochromenones Jun Pan†, Ziyao Zhang†, Lili Chen, Ning Jiao* Chin. J. Chem. 2023, 41 (5), 509–513. DOI: 10.1002/cjoc.202200603 An Efficient and Mild Oxidative Approach from Thiols to Sulfonyl Derivatives with DMSO/HBr Hongye Wang, Zhaoting Li, Rongheng Dai, Ning Jiao, Song Song* Chem. Sci. 2023, 14 (45), 13228–13234. DOI: 10.1039/d3sc04945k Alternative Method to Baeyer–Villiger Oxidation of Cyclobutenones Using I2/DMSO Catalytic Systems Yichen Sun, Zhibin Hu, Jing Peng, Qixue Qin*, Ning Jiao* Green Chem. 2023, 25 (18), 7079–7083. DOI: 10.1039/d3gc01756g Discovery of 2-(Furan-2-Ylmethylene)Hydrazine-1-Carbothioamide Derivatives as Novel Inhibitors of SARS-CoV-2 Main Protease Xiaodong Dou†, Qi Sun†, Guofeng Xu†, Yameng Liu, Caifang Zhang, Bingding Wang, Yangbin Lu, Zheng Guo, Lingyu Su, Tongyu Huo, Xinyi Zhao, Chen Wang, Zhongtian Yu, Song Song, Liangren Zhang, Zhenming Liu, Luhua Lai*, Ning Jiao* Eur. J. Med. Chem. 2022, 238, 114508. DOI: 10.1016/j.ejmech.2022.114508 Catalytic Electrophilic Halogenation of Arenes with Electron-Withdrawing Substituents Weijin Wang†, Xiaoxue Yang†, Rongheng Dai, Zixi Yan, Jialiang Wei, Xiaodong Dou, Xu Qiu, Hongliang Zhang, Chen Wang, Yameng Liu, Song Song*, Ning Jiao* J. Am. Chem. Soc. 2022, 144 (29), 13415–13425. DOI: 10.1021/jacs.2c06440 Discovery of Novel Ataxia Telangiectasia Mutated (ATM) Kinase Modulators: Computational Simulation, Biological Evaluation and Cancer Combinational Chemotherapy Study Xiaodong Dou†, Xiaojiao Sun†, Huixia Huang†, Lan Jiang†, Zefang Jin, Yameng Liu, Yang Zou, Zhongtang Li, Guiwang Zhu, Hongwei Jin, Ning Jiao, Liangren Zhang*, Zhenming Liu*, Lihe Zhang Eur. J. Med. Chem. 2022, 233, 114196. DOI: 10.1016/j.ejmech.2022.114196 Electrophilic Amidomethylation of Arenes with DMSO/MeCN Reagents Hongliang Zhang, Weijin Wang, Bingding Wang, Hui Tan, Ning Jiao*, Song Song* Org. Chem. Front. 2022, 9 (9), 2430–2437. DOI: 10.1039/d2qo00181k Selective Desaturation of Amides: A Direct Approach to Enamides Xinwei Li†, Zengrui Cheng†, Jianzhong Liu, Ziyao Zhang, Song Song*, Ning Jiao* Chem. Sci. 2022, 13 (31), 9056–9061. DOI: 10.1039/d2sc02210a Selective Carbon‐Carbon Bond Amination with Redox‐Active Aminating Reagents: A Direct Approach to Anilines Xu Qiu†, Yachong Wang†, Lingyu Su, Rui Jin, Song Song, Qixue Qin, Junhua Li, Baoning Zong, Ning Jiao* Chin. J. Chem. 2021, 39 (11), 3011–3016. DOI: 10.1002/cjoc.202100430 Cleaving Arene Rings for Acyclic Alkenylnitrile Synthesis Xu Qiu†, Yueqian Sang†, Hao Wu†, Xiao-Song Xue, Zixi Yan, Yachong Wang, Zengrui Cheng, Xiaoyang Wang, Hui Tan, Song Song, Guisheng Zhang, Xiaohui Zhang, K. N. Houk*, Ning Jiao* Nature 2021, 597 (7874), 64–69. DOI: 10.1038/s41586-021-03801-y Oxoammonium Salts Are Catalysing Efficient and Selective Halogenation of Olefins, Alkynes and Aromatics Weijin Wang, Xinyao Li, Xiaoxue Yang, Lingsheng Ai, Zhiwen Gong, Ning Jiao, Song Song* Nat. Commun. 2021, 12 (1), 3873. DOI: 10.1038/s41467-021-24174-w Cu(I)-Catalyzed [2+2+1] Cycloaddition of Amines, Alkynes, and Ketenes: An Umpolung and Regioselective Approach to Full-Substituted β-Pyrrolinones Hao Wu, Xinyao Li, Zixi Yan, Nana Ma, Song Song*, Guisheng Zhang*, Ning Jiao* Org. Lett. 2021, 23 (3), 762–766. DOI: 10.1021/acs.orglett.0c03991 N‐Heterocyclic Carbene Catalyzed Ester Synthesis from Organic Halides through Incorporation of Oxygen Atoms from Air Hui Tan, Shenan Wang, Zixi Yan, Jianzhong Liu, Jialiang Wei, Song Song*, Ning Jiao* Angew. Chem. Int. Ed. 2021, 60 (4), 2140–2144. DOI: 10.1002/anie.202011039 Electrochemical Oxidation Induced Selective C–C Bond Cleavage Shihui Shi, Yujie Liang, Ning Jiao* Chem. Rev. 2021, 121 (1), 485–505. DOI: 10.1021/acs.chemrev.0c00335 Electrochemically Induced Nickel Catalysis for Oxygenation Reactions with Water Yujie Liang, Shihui Shi, Rui Jin, Xu Qiu, Jialiang Wei, Hui Tan, Xue Jiang, Xiaomeng Shi, Song Song, Ning Jiao* Nat. Catal. 2021, 4 (2), 116–123. DOI: 10.1038/s41929-020-00559-w Molecular Oxygen-Mediated Oxygenation Reactions Involving Radicals Conghui Tang*, Xu Qiu, Zengrui Cheng, Ning Jiao* Chem. Soc. Rev. 2021, 50 (14), 8067–8101. DOI: 10.1039/d1cs00242b Nitromethane-Enabled Fluorination of Styrenes and Arenes Weijin Wang, Tongyu Huo, Xinyi Zhao, Qixue Qin, Yujie Liang, Song Song*, Guosheng Liu*, Ning Jiao*. CCS Chemistry 2020, 2 (6), 566–575. DOI: 10.31635/ccschem.020.202000172 DMSO‐Enabled Selective Radical O−H Activation of 1,3(4)‐Diols Yuchao Zhu, Ziyao Zhang, Rui Jin, Jianzhong Liu, Guoquan Liu, Bing Han, Ning Jiao* Angew. Chem. Int. Ed. 2020, 59 (45), 19851–19856. DOI: 10.1002/anie.202007187 Efficient Pd‐Catalyzed C–H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid Yizhi Yuan, Yujie Liang, Shihui Shi, Yufeng Liang, Ning Jiao* Chin. J. Chem. 2020, 38 (11), 1245–1251. DOI: 10.1002/cjoc.202000055 Rational Modification, Synthesis and Biological Evaluation of 3,4-Dihydroquinoxalin-2(1H)-One Derivatives as Potent and Selective c-Jun N-Terminal Kinase 3 (JNK3) Inhibitors Xiaodong Dou†, Huixia Huang†, Lan Jiang, Guiwang Zhu, Hongwei Jin, Ning Jiao, Liangren Zhang*, Zhenming Liu*, Lihe Zhang Eur. J. Med. Chem. 2020, 201, 112445. DOI: 10.1016/j.ejmech.2020.112445 Nitromethane as a Nitrogen Donor in Schmidt-Type Formation of Amides and Nitriles Jianzhong Liu, Cheng Zhang, Ziyao Zhang, Xiaojin Wen, Xiaodong Dou, Jialiang Wei, Xu Qiu, Song Song*, Ning Jiao* Science 2020, 367 (6475), 281–285. DOI: 10.1126/science.aay9501 From Hydroxylamines to Anilines via Trifluoroacetic Anhydride (TFAA) Assisted Stieglitz Rearrangement Xiao Luo, Ning Jiao* Acta Chim. Sinica 2020, 78 (8), 758. DOI: 10.6023/A20050191 Selective Dealkenylative Functionalization of Styrenes via C-C Bond Cleavage Jianzhong Liu, Jun Pan, Xiao Luo, Xu Qiu, Cheng Zhang, Ning Jiao* Research 2020, 2020, 2020/7947029. DOI: 10.34133/2020/7947029 Deconstructive Reorganization: De Novo Synthesis of Hydroxylated Benzofurans Ziyao Zhang, Ning Jiao* Chinese J. Org. Chem. 2020, 40 (6), 1790. DOI: 10.6023/cjoc202000031 Intramolecular Csp3–H/C–C Bond Amination of Alkyl Azides for the Selective Synthesis of Cyclic Imines and Tertiary Amines Xiaojin Wen†, Xinyao Li†, Xiao Luo, Weijin Wang, Song Song*, Ning Jiao* Chem. Sci. 2020, 11 (17), 4482–4487. DOI: 10.1039/c9sc05522c