个人简介

Michael Willis is a Professor of Chemistry and a Fellow of Lincoln College, at the University of Oxford. He graduated from Imperial College, University of London, before moving to the University of Cambridge for his PhD studies, working with Professor Steve Ley, on the total synthesis of rapamycin. He then spent two years as a NATO/Royal Society research fellow at Harvard University working with Professor David Evans. His postdoctoral work was based in the development and application of chiral Cu(II) Lewis acid catalysts, specifically, in the development of new enantioselective Mukaiyama Michael reactions. In 1997 he returned to the UK and he was appointed to a Lectureship in the Department of Chemistry at the University of Bath. He moved to Oxford in January 2007, and was promoted to Full Professor in 2013. His research interests are based around the development of new catalytic processes and their application in synthesis

研究领域

Organic Chemistry

Research in the Willis group is focused on developing new catalytic methods to meet the demands modern science places on synthetic chemistry. These can involve being able to produce specific molecules more quickly, in fewer chemical steps and with the production of less waste materials than ever before. The ability to prepare molecules never before synthesised, or to deliver many related structures with only minor adjustments to the synthetic method are also common goals. To achieve these aims we are involved in the development of new reactions, new asymmetric processes and new strategies for synthesis. Small molecule activation; sulfur dioxide in synthesis Desulfinylative cross-coupling; tackling challenging heterocyclic couplings Aza-Sulfur reagents; emergence in industrial applications Rhodium catalysis for sustainable synthesis

近期论文

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"Photocatalytic late‑stage functionalization of sulfonamides via Sulfonyl Radical Intermediates", Michael J. Tilby, Damien F. Dewez, Loїc R. E. Pantaine, Adrian Hall, Carolina Martínez-Lamenca, Michael C. Willis, ACS Catalysis, 2022, 12. (doi: 10.1021/acscatal.2c01442). “Sulfondiimidamides as new functional groups for synthetic and medicinal chemistry”, Ze-Xin Zhang and Michael C. Willis, Chem 2022, 8, 1137–1146. (doi: 10.1016/j.chempr.2022.02.013). "Reductant-Free Cross-Electrophile Synthesis of Di(hetero)arylmethanes by Palladium-Catalyzed Desulfinative C–C Coupling", Janette McKnight, Andre Shavnya, Neal W. Sach] David C. Blakemore, Ian B. Moses, and Michael C. Willis, Angewandte. Chem. Int. Ed. 2022, 61, e202116775. (doi: 10.1002/anie.202116775) “A silyl sulfinylamine reagent enables the modular synthesis of sulfonimidamides via primary sulfinamides”, Mingyan Ding, Ze-Xin Zhang, Thomas Q. Davies, and Michael C. Willis, Org. Lett. 2022, 24, 1711-1715. (doi: 10.1021/acs.orglett.2c00347) "DABSO – A reagent to revolutionize organosulfur chemistry", Jonathan A. Andrews and Michael C. Willis, Synthesis 2022, 54. (doi: 10.1055/s-0040-1719864) "Sulfonyl fluorides as targets and substrates in the development of new synthetic methods", Terry Shing-Bong Lou and Michael C. Willis, Nat. Rev. Chem. 2022, 6. (doi: 10.1038/s41570-021-00352-8) "Diverse saturated heterocycles from a hydroacylation/conjugate addition cascade", Ndidi U. N. Iwumene, Daniel. F. Moseley, Robert D. C. Pullin and Michael C. Willis, Chem. Sci. 2022, 13, 1504–1511. (doi: 10.1039/d1sc06900d) “Sulfinates from amines: A radical approach to alkyl sulfonyl derivatives via donor-acceptor activation of pyridinium salts”, Jonathan A. Andrews, Loïc R. E. Pantaine, Christopher F. Palmer, Darren L. Poole, and Michael C. Willis, Org. Lett. 2021, 23. (doi: 10.1021/acs.orglett.1c03194) “Exploiting configurational lability in aza-sulfur compounds for the organocatalytic enantioselective synthesis of sulfonimidamides”, Michael J. Tilby, Damien F. Dewez, Adrian Hall, Carolina Martínez Lamenca, Michael C. Willis, Angew. Chem. Int. Ed. 2021, 60. (doi: 10.1002/anie.202109160) "Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides and Primary Sulfonamides", Pui Kin Tony Lo, and Michael C. Willis, J. Am. Chem. Soc. 2021, 143, 15576-15581. (doi: 10.1021/jacs.1c08052) "Azine-N-oxides as Effective Controlling Groups for Rh-catalysed Intermolecular Alkyne Hydroacylation", Daniel F. Moseley, Jagadeesh Kalepu, and Michael C. Willis, Chem. Sci. 2021, 12, 13068–13073. (doi: 10.1039/D1SC03915F) "Base-activated latent heteroaromatic sulfinates as nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions", Xinlan A. F. Cook, Loïc R. E. Pantaine, David C. Blakemore, Ian B. Moses, Neal W. Sach] Andre Shavnya, and Michael C. Willis, Angew. Chem. Int. Ed. 2021, 60, 22461-22468. (doi: 10.1002/anie.202109146) “How do we address neglected sulfur pharmacophores in drug discovery?” Michael J. Tilby and Michael C. Willis, Expert Opin. Drug Disc., 2021, 16. (doi: 10.1080/17460441.2021.1948008) "Sequential catalytic functionalization of aryltriazenyl aldehydes for the synthesis of complex benzenes", Sangwon Seo, Ming Gao, Eva Paffenholz and Michael C. Willis, ACS Catalysis 2021, 11, 6091–6098. (doi: 10.1021/acscatal.1c01722) "Rediscovering Sulfinylamines as Reagents for Organic Synthesis", Thomas Q. Davies and Michael C. Willis, Chem. Eur. J. 2021, 27, 8918-8927. (doi: 10.1002/chem.202100321) "Benzenemethanamine, a,a-diphenyl-N- sulfinyl-", Michael J. Tilby and Michael C. Willis, eEROS, Encyclopedia of Reagents for Organic Synthesis, Wiley, 2021. (doi: 10.1002/047084289X.rn02281) "Benzosultam synthesis exploiting sequential palladium-catalysed intermolecular aminosulfonylation and intramolecular sulfamidation", Charlotte S. Richards-Taylor, and Michael C. Willis, Tetrahedron 2021, 77. (doi: 10.1016/j.tet.2021.131988). Invited contribution to the special issue in memory of Prof. Jonathan Williams "Primary sulfonamide synthesis using the sulfinylamine reagent N-sulfinyl-O-(tert-butyl)hydroxylamine, t-BuONSO", Thomas Q. Davies, Michael J. Tilby, David Skolc, Adrian Hall, and Michael C. Willis, Org. Lett. 2020, 22, 9495–9499. (doi: 10.1021/acs.orglett.0c03505) "The 2-pyridyl problem: Challenging nucleophiles in cross-coupling arylations", Xinlan A. F. Cook, Antoine de Gombert, Janette McKnight, Loïc R. E. Pantaine and Michael C. Willis, Angew. Chem. Int. Ed. 2021, 60, 11068–11091. (doi: 10.1002/anie.202010631) "Harnessing sulfinyl nitrenes: A unified one-pot synthesis of sulfoximines and sulfonimidamides", Thomas Q. Davies, Michael J. Tilby, Jack Ren, Nicholas A. Parker, David Skolc, Adrian Hall, Fernanda Duarte,and Michael C. Willis, J. Am. Chem. Soc. 2020, 142, 15445−15453. (doi: 10.1021/jacs.0c06986)