个人简介

Employment Jan/2015 – Associate Professor, Principal Investigator Organic Chemistry Research Center (OCRC) Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University (XJTU), Xi’an, China Mar/2011 – Nov/2014 Postdoctoral Associate (Advisor: Prof. Supervisor: K. C. Nicolaou) the Scripps Research Institute, CA&Department of Chemistry, Rice University, TX, USA Jul/2006 – Aug/2007 Research Assistant(Advisor: Prof. Kuiling Ding) Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China Education Sep/2007 – Feb/2011 Ph.D. in Organic Chemistry (Advisor: Prof. Michael F. Greaney) Dissertation: Total synthesis of Merrilactone A and Anislactone A&B School of Chemistry, Edinburgh University,Scoland, UK. Funded by EPSRC and ORS scholarships Sep/2003 – Jun/2006 M.S. in Organic Chemistry (Advisor: Prof. Kuiling Ding and Prof.Mingxing Li) Dissertation: Design and Synthesis of Self-supported Chiral Catalysts for Heterogeneous Enantioselective Reactions Shanghai Institute of Organic Chemistry, CAS&Department of Chemistry, Shanghai University, Shanghai, China Sep/1998 – Jul/2002 B.S. in Chemistry, Henan Normal University, Henan, China

研究领域

复杂天然产物全合成及不对称催化方法学

natural products• total synthesis• cascade reactions• transition metal catalyst• asymmetric catalysis design and synthesis of new transition metalchiral catalysts for enantioselective reactions development of new synthetic methods and strategies for total synthesis of biologically active and architecturally complex natural products

近期论文

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Nicolaou, K. C.*, Lei Shi, M. Lu, M. R. Pattanayak, A. A. Shah, H. A. Ioannidou, M. Lamani, Total synthesis of Myceliothermophins C and D. Angew. Chem. Int. Ed., 2014.53，10970-10974. Nicolaou, K. C.*, R. Yu, Lei Shi, Q. Cai, M. Lu, P. Heretsch, A General Synthetic Approach to Functionalized Dihydrooxepines, Organic Letters, 2013, 15(8), 1994-1997. Lei Shi, K. Meyer and M. F. Greaney*, Synthesis of (±) Merrilactone A and (±) Anislactone A. Angew. Chem. Int. Ed., 2010, 49, 9250-9253. MichealGreaney*, Lei Shi, N. Nazef, Total synthesis of (±) Anislactone A and (±) Merrilactone A, Strategies and Tactics in Organic Synthesis, 2013, Vol 9, 105-147. Lei shi, X. Wang, M. Li, Z. Li, Kuiling Ding*, Engineering polymeric chiral catalyst using hydrogen bonding and metal-to-ligand coordination interaction, Angew. Chem. Int. Ed., 2006, 45, 4108-4112. Lei Shi, X. Wang,C. A. Sandoval, Z. Wang, and Kuiling Ding*, Development of Continuous Flow System for Asymmetric Hydrogenation Using Self-Supported Chiral Catalysts, Chemistry - A European Journal. 2009, 15, 9855-9867. DING Kuiling*, Wang Z., SHI Lei, Self-Supported Chiral Catalysts for Heterogeneous Enantioselective Reactions. Pure Applied Chemistry,2007, 79, 1531-1540. X. Wang, Lei Shi, M. Li, Kuiling Ding*, Heterogenization of Shibasaki’sBinol/La Catalyst for Enantioselective Epoxidation of α, β-Unsaturated Ketones with MultitopicBinol Ligands: The Impact of Bridging Spacers,Angew. Chem. Int. Ed., 2005, 44, 6362-6366. Y. Liang, Q. Jing, X. Li, Lei Shi, Kuiling Ding*, Programmed Assembly of Two Different Ligands with Metallic Ions: Generation of Self-SupportedNoyori-type Catalysts for Heterogeneous Asymmetric Hydrogenation of Ketones, Journal of the American Chemical Society, 2005, 127, 7694-7695.